Ibhaktheriya ehlasela izinkomo ingaba nesandla esibhedlela sikaCrohn
Amaqembu omonde kanye nomkhakha wezimbuzi ubhekisela esibhedlela esithinta 1 kuzo zonke izinkomo ezingu-5 e-US futhi kuthiwa uxhumano nesifo sikaCrohn. Akusaziwa uma kukhona, ngempela ukuxhumana phakathi kwamabhaktheriya atholakalayo ukuthelela izinkomo nokugula kwesibindi (IBD) . Noma kunjalo, kuyisihloko esithandekayo kakhulu iziguli nabacwaningi.
Kuyini Izifo ZikaJohne?
Isifo sikaJohne 's (YO-nees) sibangelwa amabhaktheriya i- Mycobacterium paratuberculosis futhi kulinganiselwa ukuthi yabiza umshini wezobisi u-$ 200 kuya ku-$ 250 wezigidi zamaRandi ngonyaka. Ukuqeda uJohne kuzobandakanya ukuhlola ukuthola izinkomo ezigulayo ukuze zibhubhise. Kucatshangwa ukuthi eziningi ezingamaphesenti ama-68% ezinkomo zobisi ziphethwe yisifo sikaJohne.
Inkomo elelekile ibonisa izimpawu zesifo sohudo kanye nesisindo sokulahleka njengoba amabhaktheriya ehlasela ileum yakhe. Ngokuvamile imfiva noma ubuhlungu besisu (kunzima ukuqinisekiswa ezilwaneni) nazo izimpawu. Njengoba lesi sifo sithuthuka, lonke ipheshana lokugaya liyathinteka. Ekugcineni, amabhaktheriya asakazeka kuma-lymph nodes nasendaweni yegazi. Uma inkomo ethelelekile itholakele, ivame ukuthunyelwa ekuhlatshweni - okungukuthi, iphenduke yaba steaks kanye ne-hamburger.
Indlela Izifuyo Ezithintekayo Ngayo
Amabhaktheriya abangela uJohn achitheka inkomo enesifo ekamelweni lakhe. Indlela yamanje yokuncelisa inyama isekelwe ekushiseni okuphezulu, isikhathi esifushane (HTST).
Lokhu kusho ukuthi ubisi luvutha ngo-72º Celsius (162º F) imizuzwana engu-15. Isikhathi samasekhondi angu-15 siboniswe ukuthi asanele ukubulala wonke amabhaktheriya ka-paratuberculosis, anesigxili esincane, esilula. Ngenxa yalokho, i-paratuberculosis ingaphila ngokusebenzisa inqubo ye-pasteurization futhi ibe ngamakoloni ebisi kuma-shelves esitolo.
Eqinisweni, abacwaningi bathola ukuthi ubisi olungamaphesenti angama-25% emashelele esitolo enkabeni naseningizimu yeNgilandi kwakune-paratuberculosis DNA.
Isifo sikaJohne asinqunyelwe izinkomo. Kungaphinde kuthinte ezinye izilwane ezifana nezimvu, izilwane zasendle, futhi ngokusho koososayensi baseScotland, onogwaja, izimpungushe, izigqoko, izintuthwane, amagundane kanye nezintaba. Kuthiwa ukuthi lezi zilwane zitholakale lesi sifo kusuka emfuyweni enegciwane, kodwa aziwa uma zingadlulisa amabhaktheriya emuva emfuyweni.
Xhumanisa Izifo ZaseCrohn
Inkolelo yokuphikisa ukuthi i-paratuberculosis ingabangela nesifo sikaCrohn kubantu. Ngo-1984, izinkinga ezingekho ngaphansi kwe- Mycobacterium zazihlukaniswa neziguli ezintathu zika Crohn. Ngonyaka ka-1991 kwaba lula ukukhomba lezi zinkinga ezintathu njengoba zonke ziyi-M paratuberculosis. Ngo-1992 esinye isifundo senziwa emathunjini emathumbu asuswe ngesikhathi sokuhlinzwa kusuka ku-Crohn's, i-23 ulcerative colitis, kanye neziguli ezingu-40 ezingezona ze-IBD. Amaphesenti angu-65% weziguli zesiguli sikaCrohn aqukethe i- paratuberculosis e-M , eqhathaniswa ne-12.5% kuphela yeziguli ezingezona ze-IBD. Abacwaningi baphetha ngokuthi uM paratuberculosis "udlala indima etiological kwezinye izimo zesifo sikaCrohn."
Ngonyaka we-1998 iNational Institute of Ebola kanye ne-Infectious Diseases (i-NIAID) yabamba i-workshop ukuze ithathe izincomo zokuqhubeka nokucwaninga ngokuxhumana phakathi kwe- M paratuberculosis ne-Crohn's disease.
Abahlanganyeli bavuma ukuthi ubufakazi obuningi besayensi buyadingeka ukufakazela noma ukuphikisa ukuthi i- M paratuberculosis ingabangela isifo kubantu. Amaphuzu amaningana okucwaninga okuqhubekayo atholakala.
Izinyathelo Ezilandelayo Ekucwaningweni
Iqembu lokugqugquzela isiguli, i-Paratuberculosis Awareness and Research Association, Inc (PARA), liye ladlala indima ebalulekile ekunakekeleni le nkinga. Ngo-March 2001, uCheryl Miller, uMqondisi we-Co-executive of PARA, ufakaze ngaphambi kwekomidi elincane le-US Congress House Appropriations Committee, e-Labor, Health and Human Services, kanye neMfundo ebacela ukuba babekele eceleni imali ngenhloso yokucwaninga isifo sikaCrohn.
Lezi zintuthuko ukugxila kocwaningi oluthile mayelana nalokho okubangelwa yisifo sikaCrohn. Manje sekucatshangwa ukuthi i-IBD empeleni iyinkulungwane yezifo, futhi kungenzeka kube nezimbangela eziningi eziningi.
Imithombo:
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Sanderson JD, Moss MT, Tizard MLV, uHermon-Taylor. "I-Mycobacterium paratuberculosis i-DNA e-Crohn's tissue." Gut 1992; 33: 890-896.