I-Huma isetshenziselwa ukuphatha izifo zikaCrohn kanye ne-Rheumatoid Arthritis.
U-Humira (adalimumab) ungumuntu omzimba we-monoclonal. Isebenza ngokuvimba isifo se-necrosis se-alpha (TNF-alpha) , i- cytokine edlala indima enkambeni yokuvuvukala.
Abantu abanezifo zesifo sofuba (IBD) banesilinganiso esingavamile se-TNF-alpha, futhi kucatshangwa ukuthi lokhu kudlala indima kule nqubo yesifo. UHuma uyeka i-TNF-alpha kusukela ekusetshenzisweni komzimba.
Huma uthathwe kanjani?
U-Humira ufika ngesimo somjovo futhi kufanele agcinwe esiqandisini. Umjovo unikezwa ngaphansi kwesikhumba (ngaphansi kwesigqila) ekhaya noma ehhovisi likadokotela. U-Humira unikezwa kanye njalo ngesonto noma ngezinye izikhathi ngesonto. I-dosage ngokuvamile i-40 milligrams. I-Humira akufanele ijowe endaweni efanayo emzimbeni izikhathi ezimbili ngokulandelana. Iziguli kufanele zijikeleze lapho zinika khona umjovo - ngokuvamile isisu noma phambili kwethanga. Udokotela ochaza uzohlinzeka noma yiziphi iziyalezo ezikhethekile futhi achaze indlela yokuphatha umjovo ekhaya, uma kunesidingo. Uma unemibuzo yokuthi ungayinika kanjani umjovo, ungabiza (800) 4HUMIRA (448-6472).
Kungani Kulotshiwe?
I-Humira ingabekwa ukuba isifo se-Crohn noma isifo sofuba esiswini, izinhlobo ezimbili eziyinhloko ze-IBD. Kuvame ukunikezwa emva kweminye imithi evivinywa futhi ayisebenzi noma uma izimpawu ze-IBD zinzima kakhulu.
I-Humira ivunyelwe ukusetshenziswa kubantu abadala nakwabantwana abangaphezu kweminyaka engu-6.
I-Humira inganciphisa izimpawu ezivamile ze-IBD (ubuhlungu, ukukhathala nokuhuda) noma kungenza ukukhululwa. Ngesilingo esisodwa semitholampilo yeziguli ezine-Crohn's disease, amaphesenti angu-40 kuya kwangu-47 iziguli eziphathwe noHuma zilahlwe ngemuva kwamasonto angu-26 zokwelapha.
Ngemuva kwamasonto angu-56, iziguli ezingaba ngu-40 zisazobe sezikholelwa.
Ubani Akufanele Ayithathe Huma?
Tshela udokotela wakho uma uhlelwe noma yikuphi uhlobo lokuhlinzwa noma ube nokugoma okwakamuva. Futhi vumela udokotela wakho wazi uma uke waba nanoma yiziphi izimo ezilandelayo:
- Ukusabela okwe-allergen kunoma imiphi imithi
- I-Cancer (i-lymphoma)
- Okwamanje ukhulelwe
- Ukutheleleka kwefungal
- Ukuhluleka kwenhliziyo
- I-hepatitis B
- Lupus
- Multiple sclerosis
- Izifo ezijwayelekile
- Ukuzizwa
- Isifo sofuba
Yiziphi Imiphumela Ezingezansi zikaHuma?
Umphumela ovame kakhulu ohlangothini lweHuma ubuhlungu, ukucasuka, ukuvuvukala noma ukuchithwa esakhiweni somjovo. Eminye imiphumela emibi ejwayelekile ihlanganisa ikhanda, ukukhwabanisa nokuhlanza izinhlanzi. Kukhona ingozi yokuthuthukisa ukutheleleka okukhulu uma uthatha uHuma, nakuba kungenakwenzeka. Tshela udokotela wakho uma uhlakulela noma yiziphi izimpawu noma izimpawu zokutheleleka noma uma ezinye izimo ezimbi zihlupha noma ungahambi.
Imiphi Imithi Engayithinta?
Akukhuthazwa ukuthi uHumira athathe amanye ama-TNF-ukuvimbela ama-agent, njenge-Kineret (anakinra), imigomo ephilayo noma i-methotrexate. Tshela udokotela wakho uma uthatha noma yiziphi izidakamizwa ezivimbela isimiso somzimba sokuzivikela, njenge-cyclosporine.
Ingabe Kukhona Ukusebenzisana Ukudla?
Akukho ukusebenzisana kokudla okuyaziwayo.
Ingabe Ukuphefumula Kuphephile Phakathi Nokukhulelwa?
I-FDA ihlukanise i-Humira njengesidakamizwa sohlobo B. Izifundo ezilwaneni azikhombisi ubufakazi bokulimaza komntwana; Kodwa-ke, azikho izifundo ezanele ezilawulwa kahle kwabesifazane abakhulelwe. I-Huma kufanele isetshenziswe kuphela kwabesifazane abakhulelwe lapho kudingeka. Yazisa udokotela uma ekhulelwa ngenkathi ethatha uHumira.
Esinye isifundo esincane sibonisa ukuthi uHumira uwela i-placenta futhi angene egazini le-fetus ngesikhathi se-trimester yokugcina yokukhulelwa. U-Huma ungatholakala emanzini wegazi kusukela ezinyangeni ezintathu emva kokuzalwa. Kunconywa ukuthi izingane ezizalelwa kumama ezithatha u-Humira zihlolwe ngokutheleleka ukutheleleka kwezinyanga zokuqala eziyisithupha zokuphila, futhi zingatholi noma yiziphi izigciwane eziphilayo ezizophila ngaleso sikhathi.
Ayaziwa uma uHumira edlulela ebisi lwebele; Kodwa-ke, ezinye izinto ezifanayo ziye zaboniswa ukuthi zidlule ubisi lwebele. Ukuncelisa isisu ngenkathi kuthatha i-Humira akukhuthazwa.
Ngenzenjani Uma Ngilahlekelwa Udoti?
Uma ulahlekelwa umthamo, thatha ngokushesha uma ukhumbule. Bese uthatha umthamo wakho olandelayo ngesikhathi esihleliwe ngaso sonke isikhathi. Ungaphindi kabili noma uthathe isilinganiso esingaphezu kwesisodwa ngesikhathi.
Imithombo:
Abbott Laboratories. "Huma Umhlahlandlela Wezokwelapha." Humira.com Mar 2011. 17 Apr 2011.
Colombel JF, uSandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R, Schreiber S, Byczkowski D, Li J, Kent JD, Pollack PF. "I-Adalimumab yokugcinwa kwempendulo yemitholampilo nokukhululwa kweziguli ezine-Crohn's disease: isilingo se-CHARM." I-Gastroenterology 2007 Jan; 132: 52-65. 17 Meyi 2011.
I-Mahadevan U. "Amanqanaba e-Adalimumab ahlonzwe Ngendandatho Igazi nezingane ezisetshenzisiwe e-Utero (Abstract # 277)" Iviki lokugaya izifo 2011. 26 Feb 2012.
I-PDR Health. "Humira." Thomson Healthcare 2008. 17 Apr 2011.