Ungathatha i-Estrogen Nge-Cancer Yamabele
Sekuyiminyaka abesifazane nabodokotela babo bekhathazekile ukuthi ukuthatha i-estrogen kungabangela umdlavuza webele. Ngifingqa ukuthi kungani lokhu kwakungenjalo lapho ngisanda kushicilelwa incwadi, i-The Estrogen Window, nokuthi i-estrogen kanjani, ethathwe efenjini lakho le-estrogen, empeleni libeka ingozi yomdlavuza webele. Kodwa-ke, ukwesaba ukuthatha i-estrogen kuye kwaba kuhle kangangokuthi abesifazane abavele benesifo somdlavuza webele babonakala bengavamile ukusebenzisa noma yiluphi uhlobo lwe-estrogen kubandakanya i-estrogen yesisu.
Lokho kwakha inkinga enkulu kakhulu yabesifazane abanomdlavuza wesifuba. Ngaphandle kwezinguquko zomzimba ezenzeka ngenxa yokukhishwa kokuhlinzwa komdlavuza noma ezimweni eziningi, isifuba, kunezibonakaliso zokunqamuka kwesikhashana. Izindaba ezinhle ukuthi izici zomzimba zingabhekana nokuhlinzwa okulungiswayo kanti ngenkathi kungesona isixazululo esiphelele, kuyindlela ebalulekile yokubhekana nemiphumela yokwelapha yokwelashwa.
Kodwa-ke, izimpawu zokunqamuka kwesikhashana ziye zaba nzima kakhulu ukubhekana nazo kusukela isrogen iyindlela yokwelapha ephumelela kakhulu etholakalayo. Kube khona imithi emibili engeyona i-estrogen evunyelwe ukubhekana nezimpawu zokumisa esikhathini. Ukushisa okushisayo (i-Brisdelle) kanye nokomama wesisu (i-Osphena), kepha ukumelela kwesisu nomzimba obuhlungu kuyisici esikhulu samantombazane amaningi athola ukwelashwa komdlavuza webele.
Manje kunombiko oguqula umdlalo oshicilelwe yi-American College of Obstetricians and Gynecologists (ACOG).
Ikhomishana entsha yeKomidi yaseMelika College of Obstetricians and Gynecologists (Inombolo 659, Mashi 2016) ithi i-ACOG ikholelwa ukuthi kukhona ubufakazi obanele bokuthi kulungile (ukusebenza ne-oncologist yakho) kwabesifazane abanomdlavuza wesifuba we -estrogen othembekile ukuze bathathe isrogen yesisu . Nakuba i-estrogen ingena egazini, akubonakali kuthinta umphumela.
Amazinga wegazi awadluli lokho okujwayelekile amazinga e-estrogen wegazi asemkhathini.
Futhi kukhona ubufakazi bokusibuyisela emuva. Kungakhathaliseki ukuthi okwamanje uphathwa isifo somdlavuza webele, uye waphathwa isifo somdlavuza esikhathini esedlule, futhi noma ngabe uthatha i-Tamoxifen, okuyi-anti-estrogen, imiphumela yokusebenzisa i-estrogen yangasese ayihlukile uma ungenayo Ithahe. Ngikhuluma ngalokhu kanye nolwazi olubalulekile oluhlobene ne-estrogen encwadini yami entsha, i-The Estrogen Window.
Lokhu kuyinhloko kwabesifazane ngoba umdlavuza webele ungumdlavuza ovame kakhulu kubantu besifazane phakathi kwazo zonke izinhlanga. Kubuye kube imbangela eyinhloko yomdlavuza ekufeni phakathi kweSpainan. E-United States, umdlavuza webele ushukumisa owesifazane oyedwa kwabayisishiyagalombili kanti okwamanje kunabesifazane abangaphezu kwezigidi ezimbili zase-US abaye baphathwa ngomdlavuza webele.
Kunezinhlobo eziningana ze-estrogen yesisu:
| Indlela enikeziwe ngayo | Kuyini Kuyo | Kuthathwa kanjani |
| I-Cream yamaVaginal | 17 beta estradiol | Ngokuvamile 1-2 amagremu nsuku zonke amaviki angu-1-2, bese u-1 gramu izikhathi ezingu-1-3 / isonto |
| I-Cream yamaVaginal | Wathinta i-equine estrogen | Ngokuhamba ngama-0.5 amagremu ngezinsuku ezingu-21 bese kuphuma izinsuku ezingu-7, noma kabili ngesonto uma kunzima kakhulu |
| Ring Ring | 17 beta estradiol | I-2-mg ring ikhulula ama-7.5 micrograms / usuku ngezinsuku ezingu-90 |
| Ithebula le-Vaginal | I-Estradiol hemihydrate | Ithebulethi eyodwa ye-10 / day for amasonto amabili bese eyodwa 10 microgram tablet / ngosuku 2-3 izikhathi / ngesonto |
Eziningi zokwelashwa kwe-chemotherapy ezisetshenziselwa ukusebenza komdlavuza wesifu ngokuyingxenye ngokuqeda noma ukuvimbela konke ukukhiqizwa kwe-estrogen. Ngenxa yalokho, abesifazane base-perimenopausal abasenesikhathi sokuya esikhathini ngokuzumayo bagxila ekunqumeni kokuya esikhathini futhi abesifazane abasesimeni sokuya esikhathini okwamanje abanamazinga aphansi e-estrogen banikezwa imithi yokwelapha ethatha amazinga e-estrogen aphansi futhi ayiphundule.
Omunye wemiphumela emibi kunazo zonke yokungenayo i-estrogen kuyinto eyomile yangasese, ukunciphisa amathisini omzimba wesisu nesibindi okuthiwa i-atrophic vaginitis. I-term yezokwelapha entsha yalokhu i-Genitourinary Syndrome ye-Menopause (GSM) eyabangela ubulili obubuhlungu futhi ngezinye izikhathi ubudlelwane obunzima.
Lokhu kuyishintsho enkulu yemidlalo yabesifazane abanomdlavuza wesifuba. Nakuba ngihlinzeka nge-estrogen yamasini ngokukhetha izigulane zomdlavuza webele, iminyaka eminingi inqabe ukwelashwa ngoba i-oncologists yabo ithe akufanele ithathe futhi iqondise kahle. Umdlavuza wesibeletho wedwa walungile ngokwanele. Futhi nakuba ukwelashwa okungewona ama-hormone kukwanele ukuphatha izimpawu ze-GSM kwabanye, akukho mbuzo ukuthi abesifazane abaningi bayozuza ngokusebenzisa ukusetshenziswa kwesisu se-vagin; kuyisisombululo esiphumelele kunazo zonke sokukhulula izimpawu ze-GSM. Manje i-estrogen izoba yindlela eyamukelekayo yabaningi besifazane abanomdlavuza webele.