Nakuba i-melatonin iyi-hormone ebuchopho obukhiqiza ngokwemvelo, ungase ukwazi kangcono njengendlela yokulungisa ngaphezulu kwe-jet lag kanye nokuphazamiseka kokulala. I-pineal gland yengqondo yobuchopho ifihla i-melatonin kumjikelezo wamahora angu-24. Iphinde ikhiqizwe esikhumbeni, i-retina yeso kanye nomnyofu wethambo.
Emvelweni, ukukhiqizwa kwezingxenye ze-melatonin ebusuku, futhi kuvinjelwe ukukhanya kosuku.
Ngobumnyama kufika amazinga akhula we-melatonin, okuletha ukwehlisa nokuthula-futhi ngethemba, ukulala. Ezinye izici nama-hormone afana ne-serotonin nazo zibalulekile, kodwa, ekulawuleni imijikelezo yomzimba yokulala .
Ukulala, i-Melatonin ne-Cancer
Izifundo ezibonisa ukuxhumana phakathi kokulala okuncane, amazinga aphansi e-melatonin nomdlavuza kuye kwaba nomthelela omkhulu. Umsebenzi wokushintsha ebusuku ubhekene nokukhathala nokulala, amazinga aphansi e-melatonin egazini, nezifo eziningi ezihlukahlukene ezihlanganisa isifo senhliziyo, isifo se-metabolic syndrome-kanye namanqamu ezinhlobonhlobo.
Ishift Work and Cancer Risk
Konke lokhu okutholakele kwabasebenzi be-shift kwabangela abanye ososayensi ukuba bazibuze ukuthi ngabe i-melatonin ingase isize yini ukuvikela abantu kulezi zifo. Ucwaningo olulodwa lwaseCanada kubantu abasebenza besilisa lathola ukuthi umsebenzi webusuku wawuhlotshaniswa nezimpikiswano ezinkulu ezihlukahlukene ze-khansa, kuhlanganise ne- non-Hodgkin lymphoma .
Lezi zinhlobo zezifundo zibuka ukubona ukuthi izinto ezivamile zihlobene kanjani nenye into-"zihlukaniswa," noma okuthiwa yi-epidemiological in nature.
Idatha evela ezifundweni ezifanayo ibonakala ifaka indima engenzeka kuyo i-melatonin nokuphazamiseka kokulala emdlalweni wesikhumba futhi: abesifazane abasebenza ubusuku obusuku banamaphesenti angu-19 kuya kwangu-51 banda ingozi yomdlavuza webele. Ngokuqondene nomdlavuza we-prostate , isifundo esisodwa sathola ukuthi amadoda anomdlavuza we-prostate anamazinga aphansi e-melatonin uma kuqhathaniswa namadoda ayenawo umonakalo ongenawo umdlavuza kodwa ongase aphazamise ukulala, benign prostatic hyperplasia.
Ayikho yalezi zifundo yindlela engabonisa imbangela nomphumela, noma kunjalo. Okutholakele kuyasiza ukunikeza izifundo ezengeziwe, kodwa akusekeli ukusetshenziswa kwe-melatonin ukuvimbela umdlavuza.
Idatha yezilwane nelabhulali
Ucwaningo lwe-laboratories lubonisa ukuthi i-melatonin i-antioxidant enamandla enamandla futhi evuselela ezinye izingxenye zesimiso somzimba sokuzivikela komzimba, kodwa aziwa ukuthi lokhu kwenzeka kumuntu. I-Melatonin ibonakala ivimbela amanye amangqamuzana omdlavuza ukuthi angakhuli uma esebenziswa ngokuqondile kulawa maseli ezitsheni zokulabhulabhu nasezifundweni zezilwane-lo mphumela ubonwe umdlavuza webele kanye ne-melanoma.
Izifundo kubantu, noma kunjalo, aziphakamisi nanoma iyiphi impikiswano ye-antiticancer.
Ngokusekelwe kwedatha ye-in vitro, ososayensi abathile baye bacabanga ukuthi ukuvuselelwa kwe-immune, uma kukhona e-vivo, kungenzeka ukuthi akuyona into enhle kuzo zonke izimo. Ngokwesibonelo, uhlobo olungalungile lwe-immune stimulation kulabo abanezifo ezine-leukemia noma i-lymphoma kungase kube yinto engabonakali, ngoba lezi zomsana zibandakanya ukulimala kwamasosha omzimba emzimbeni we-lymph, umnkantsha wegazi kanye negazi.
I-Melatonin ezinhlobonhlobo zokuhlola iye yabonisa ezinye izakhiwo zokulwa nomdlavuza, futhi ukucutshungulwa kwesimiso sokuzivikela komzimba kucatshangwa ukuthi kuhilelekile. Ucwaningo olwenziwa nguMiller luphakamisa ukuthi i-melatonin iqhaza ekusebenziseni kwe-lymphocytes kanye ne-monocytes / macrophages-izinhlobo ezahlukene zamangqamuzana amhlophe egazi.
I-Lymphomas yi-cancer evela kuma-lymphocytes.
I-in vitro, i-melatonin ibonakala ithatha isenzo sombulali we-T-cell owandayo , eshukumisa ezinye izibonakaliso zamaseli ezibizwa nge-cytokines; kungase futhi kuvimbele ezinye izandulela zegazi ezisezingeni eliyingozi le-chemotherapy kanye ne-radiotherapy , ngokusho kwesifundo se-2001 sikaMaestroni.
Futhi, awaziwa ukuthi i-melatonin ingaba nomphumela yini ku-vivo, kuziguli zangempela.
I-Melatonin ekwelashweni kwe-Cancer
Okuncane kangako kwaziwa nge-melatonin uma isetshenziswe kubantu abanomdlavuza. Iqembu elilodwa labaososayensi lihlelwe ngokuhlelekile imiphumela ye-melatonin lapho inikezwa kanye ne-chemotherapy, i-radiotherapy, ukunakekelwa okusekelayo, nokunakekelwa kokunakekelwa kweziguli ezigulini eziqinile zemetrasi - hhayi i-leukemia noma i-lymphoma.
Kulolu cwaningo, i-melatonin ayihlotshaniswa nokudakwa okweziwe noma ukunciphisa ukwelashwa okunciphise, futhi kubonakala kunisiza ngemiphumela emibi ye-chemotherapy.
I-Melatonin eneziguli ze-Blood Cancer
Ngaphansi kwalokho uyaziwa uma kuziwa ku-melatonin kubantu abanegazi elidla igazi elifana ne-leukemia ne-lymphoma . Imihlahlandlela yamanje ye-National Comprehensive Cancer Network (NCCN) kwi-non-Hodgkin lymphomas, uhlobo oluvame kakhulu lwe-lymphoma, alufaki izincomo ekusetshenzisweni kwe-melatonin.
Iningi locwaningo olushicilelwe okwamanje nge-melatonin oluthile oluhlobene ne-lymphoma lubonakala luvela ku-data ye-vitro nesilwane, hhayi ukuhlolwa kwemitholampilo.
Khuluma njalo nodokotela wakho mayelana nokuthatha noma yikuphi okungeziwe, ngoba izithako zingaba nemiphumela emibi kanye nokusebenzisana kwezidakamizwa.
Izwi kusuka:
I-Melatonin isetshenziswe ngokuphepha njengabantu abaningi abalala, futhi inendima ebalulekile ekwelapheni ukuphazamiseka okuhlukahlukene kokulala.
I-Melatonin ngumkhiqizo wemvelo, kodwa imikhiqizo yemvelo ingasenayo imiphumela emibi kanye nokusebenzisana okungalindelekile. I-Melatonin ingase ihlanganyele nemithi ehlukahlukene, kuhlanganise nezidakamizwa, izidakamizwa zokucindezeleka, imithi ye-hormonal, nezinye.
Xoxa nodokotela wakho mayelana nokusebenzisa kwakho i-melatonin noma yimuphi omunye umphelelisi-ikakhulukazi uma uphathwe umdlavuza noma esinye isifo esingapheli.
Imithombo
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Imihlahlandlela ye-NCCN kwi-Non-Hodgkin Lymphoma. Inguqulo 1.2016. Kufinyelelwe ngo-February 2016.