I-HER2 , ebizwa nangokuthi i-HER2 / neu ne-HER-2, isichazamazwi se-epidermal growth factor receptor 2. Ukwazi isimo sakho se-HER2 yingxenye ebalulekile yokuxilongwa kwakho.
I-HER2 isisindo esichaza amaprotheni esivela phezulu kwamangqamuzana. Iseli lesifuba enempilo linamakhophi amabili wegciwane le-HER2. Ezingamaphesenti angaba ngu-30 ezomdlavuza wamabele, amangqamuzana omdlavuza wesifuba anamakhophi angaphezu kwamabili alowo geni, futhi lokhu kuholela ekukhiqizeni ngaphezulu kweprotheyini ye-HER2.
Ngenxa yalokho, amangqamuzana abathintekile akhula futhi ahlukanise kakhulu ngokushesha.
Ukuvezwa ngokweqile noma ukukhuliswa kwegciwane le-HER2 kuboniswe ukuthi kudlale indima ebalulekile ekuthuthukiseni nasekuthuthukisweni kwezinhlobo ezithile zomdlavuza webele kanye nezinye izinhlobo zomdlavuza.
Ingabe Ifa?
Le nkinga yofuzo ayizukuzuzwa kubazali bakho. Ukungajwayelekile kwaleli gciwane kuhlobene nenqubo yomdlavuza.
Imiphumela Yokuhlola Okungalungile Nezimbi
Uma umdlavuza wakho webele uhlolwe isimo se-HER2, imiphumela izobe ibanjwe njengokuhle noma okungalungile. Uma imiphumela yakho ibanjwe njenge-HER2 emihle, lokho kusho ukuthi ama-gene wakho we-HER2 aphelile-okhiqiza amaprotheni angu-HER2. Uma imiphumela yakho ihlanganisiwe i-HER2 engalungile, ama-gene we-HER2 awakhuliswa.
Izindlela zokwelapha ezitholakalayo
I-Herceptin (trastuzumab) iyisidakamizwa esetshenziswa njengamanje ukuphatha umdlavuza webele we-HER2 omuhle. Kuyinto yokwelashwa okuhlosiwe futhi kuthiwa nokuphathwa ngamagciwane.
Lesi sidakamizwa sizonikezwa kwangaphakathi, kanye kanye namasonto amabili kuya kwamathathu. Uma kusesimweni sakho, i-Herceptin ihlose amaprotheni e-HER2 avela ngenani elingaphezu kwamangqamuzana omdlavuza wesifuba. Lokhu kusiza ukuvimbela ukukhula kwamaseli omdlavuza we-HER2 omuhle.
Enye imiphumela ye- Herceptin yokwelapha ihlanganisa:
- ihlehlisa ama-HER2 emihle, ngaphambi kokuhlinzwa
- ilahle ama-HER2 amangqamuzana omdlavuza omzimba asakaze ngaphezu kwe-tumor yangempela.
- Isiza ukuvimbela ukuphindaphinda (ukubuyisela) komdlavuza omuhle we-HER2
Izivivinyo ze-HER2
Udokotela wakho angase abize ukuhlolwa okumbalwa:
- I-FISH: I-Fluorescence In Hybridization-Lokhu kuhlolwa kusebenzisa ama-probe e-fluorescent ukubuka amakhophi wegciwane le-HER2 kwiseli lesisu. Uma kukhona amakhophi angaphezu kwamabili wegciwane le-HER2, umdlavuza u-HER2 omuhle.
- I-IHC: ImmunoHistoChemistry- lokhu kuhlolwa kuqapha ukukhiqizwa kweprojekthi ye-HER2 yi-tumor. Imiphumela yokuhlolwa ihlelwe njenge-0, 1+, 2+, noma i-3+. Uma imiphumela ingu-3+, umdlavuza wakho u-HER2-positive. Uma imiphumela ingu-2+, uzodinga ukuhlolwa kwe-FISH ukuthola ukuthi umdlavuza u-HER2-positive.
Okubalulekile
I-HER2 umdlavuza wesifuba omuhle utholakala yi-IHC noma i-FISH test. Umphumela we-HER 2 positive ubalulekile, njengoba kubonisa ukuthi umdlavuza ungaphathwa ne-Herceptin, kanye nePerjeta neKadcyla. Uma umdlavuza wakho ubhekwa njenge-HER2 positive, kungenzeka ukuthi unonya. Ukuqala ukwelashwa ngokushesha ngangokunokwenzeka kuzosiza ekuthuthukiseni ukusinda kwakho, kanye nokusiza ukuvimbela ukuphindaphindiwe.