Yiziphi izidakamizwa ezakhiwa ukuphatha izifo zika Crohn kanye ne-Ulcerative Colitis?
Eminyakeni yamuva nje, ukwelashwa kwesifo sofuba (IBD) esibangele ukutholwa kakhudlwana ezinkampanini zemithi kanye nabacwaningi. Ikusasa labantu abane-IBD likhanya kunanini ngaphambili, njengoba izidakamizwa eziningi zikhona emgqeni wokuphatha lezi zifo ezikhubaza kanye nezinkinga ezihambisana nazo.
I-Alicaforsen
I-Alicaforsen okwamanje ilawulwa yi-Atlantic Pharmaceuticals Limited.
Isidakamizwa silawulwa yi- enema futhi sihlolwa ukuthi sisetshenziswe ku-ulcerative colitis ne- pouchitis . I-Alicaforsen inikezwe isimo sezidakamizwa e-United States nase-European Union.
Alequel
U-Enzo Biochem usuqedile ukutadisha u-Alequel ezigulini ezinesimo esifanayo nesifo esibi seCrohn. Isidakamizwa singelashwa ngokwezifiso kokukhishwa kwamaprotheni okudalwe kusuka kumcubu kusuka kololon isiguli futhi ephathwe ngomlomo. Ukukhululwa kwafinyelelwa ngamaphesenti angu-50 eziguli ezidakamizwa, ngokumelene namaphesenti angu-33 ane-placebo. Isidakamizwa sasinakekelwa kahle, kungekho miphumela emibi.
I-Teduglutide
Lesi sakhi esisha sihlolwe ukusetshenziswa kokubili i-IBD ne- short bowel syndrome (SBS) . I-SBS yisimiso esibangele ukuhuda, ukuchoboza, ukubhuqa, nokushaya kwenhliziyo okwenzeka kubantu abanesigamu (noma ngaphezulu) samathumbu amancane asuswe. Isizathu esivame kakhulu se-SBS sihlinzekwa ngokuphindaphindiwe kokuhlinzekwa kwemikhiqizo esetshenziswa ukuphatha isifo sikaCrohn.
Imiphumela emibi ye-teduglutide ibonakala ingaphansi, njengoba imiphumela ivela ikakhulukazi emgodleni wamathumbu. Abantu abane-SBS abahlanganyele ekuvivinyweni kwe-teduglutide babonise kokubili ukwandisa izakhi zokudla kanye nesisindo somzimba. Imiphumela emibi evame ukubikwa yayihlanganisa ubuhlungu besisu, ukukhanda ikhanda, izinguquko zesimo, nokuvuvukala.
I-NPS Pharmaceuticals, umthuthukisi we-teduglutide, igcwalise isifundo sobufakazi bokuhlola emagulini abane-Crohn's disease. Kulezi ziguli ezine-Crohn's, amaphesenti angu-55 ayefinyelele ukuxoshwa ngemuva kwamasonto ayisishiyagalombili okusebenzisa lesi sidakamizwa, uma kuqhathaniswa namaphesenti angu-33 weziguli ezithola i-placebo. Umphumela omubi kakhulu obikiwe wawubomvu endaweni yomjovo. Esinye isifundo senziwa ezigulini ezine-SBS.
I-Teduglutide inikezwe isimo sezintandane sezintandane ku-United States naseYurophu ngokusetshenziswa kwayo ku-SBS. I-NPS okwamanje ifuna umlingani wokuthuthukiswa ukuze iqhubeke nokuhlola isidakamizwa ukuze isetshenziswe kwisifo sikaCrohn.
I-Traficet-EN (CCX282)
I-Traficet-EN iyi-anti-inflammatory therapeutic encane okwamanje ehlolwayo ukuze isetshenziswe kwisifo sikaCrohn ngumkhiqizi wayo, i-ChemoCentryx. Ekulingweni kwamuva (PROTECT-1), iphesenti enkulu yeziguli ezithola lesi sidakamizwa sithole ukukhululwa ngemuva kwamasonto angu-36 kunelabo abathola i-placebo. Lesi sidakamizwa sasibekezeleleke kahle phakathi kwabahlanganyeli bezocwaningo esikhathini esivivinyweni sezinyanga ezingu-12.
Imithombo:
I-ChemoCentryx. "Uhlelo lwe-CCR9.". 2010. 26 Juni 2010.
Enzo Biochem, Inc. "U-Alequel." . 2010. 26 Juni 2010.
Isis Pharmaceuticals, Inc. "Izifo Ezivuthayo." . 2010. 26 Juni 2010.
UMargalit M, Israeli E, Shibolet O, Zigmond E, Klein A, Hemed N, Donegan JJ, uRabbani E, Goldin E, Ilan Y. "Isivivinyo somtholampilo ophindwe kabili ukuphathwa kwesifo sikaCrohn ngokuphathwa komlomo ka-Alequel, ingxube we-protologous-colon-etholakalayo. " Am J Gastroenterol Mashi 2006 101: 561-568. 26 Juni 2010.
I-NPS Pharmaceuticals. "Amathuba okuhlanganyela we-NPS." 2010. 26 Feb 2012.