I-Lupus ingenye yalezi zifo ezingaqondakali ukuthi odokotela abazange baphonswe phansi. Akekho owazi ngokuqinisekile nokuthi kungani kwenzeka. Kodwa-ke, ochwepheshe abaningi bakholelwa ukuthi i-lupus ibangelwa ukuhlanganiswa kwezakhi zofuzo nezendalo-okungukuthi, izinto ongakwazi futhi ezingakwazi ukulawula.
Ngeke kube yilapho isayensi ithatha isifo esizoyiqonda ngempela izimpande zayo.
Okwamanje, singabheka abanikeli abakholelwa ukuthi bangene lupus njengoba ososayensi bawaqonda manje.
Izingozi Ezivamile Zengozi
I-Lupus yisifo esizimele esisodwa lapho amasosha omzimba wakho angasebenzi khona, okwenza umzimba wakho uhlasele izicubu zawo. Lezi zici zibhekwa njengezicabangela ezivamile:
Amahomoni
Ucwaningo lubonisa ukuthi izimo ze-hormone zixhunyaniswa nesifo esizimele, nakuba ucwaningi lusasencane futhi ukuxhumana phakathi kwalezi zinsuku kusenempilo. Uma sicabanga ukuthi amaphesenti angu-90 abantu abane-lupus abesifazana, i-hormonal factor ibonakala ibalulekile. Noma kunjalo, amahomoni wesifazane afana ne-estrogen abonakala engabangela i-lupus. Kunalokho, kubonakala sengathi kwandisa ingozi kulabo asebevele bengakwazi ukuthuthukisa lesi sifo.
Ukutheleleka
Ama-viruses nama-bacteria angadlala indima ekuthuthukiseni kwe-lupus, kodwa isixhumanisi esiqondile se-causal asisungulwe. Kodwa-ke, ukutheleleka kukhonjiswe njengenye yezinto ezivame kakhulu ezibangelwa ukuthuthukisa i-lupus.
I-Epstein-Barr virus (EBV) ezinganeni ixhunyaniswa ne-lupus yobuntwana, kanye ne-lupus kubantu abadala. Ama-viruses nama-bacteria angabangela futhi ama-lupus flares.
Imithi
Kuye kwaqalwa ukuthi ezinye izidakamizwa zibangelwa i-lupus ne-lupus flares. Eqinisweni, i-subset yalesi sifo, i -lupus eyenziwe izidakamizwa , isekelwe kulokhu.
Loluhlobo lwe-lupus luvame ukulethwa ukusetshenziswa kwesikhathi eside kwemithi ethile efana ne-anticonvulsants, antibiotics, kanye nemithi yokucindezelwa kwegazi kanye nezimpawu cishe zihamba njalo lapho umuthi unqanyuliwe.
Ngaphezu kwalokho, ukwelashwa kwemithi kubonakala kaningi kubantu abane-lupus esanda kutholakala kunelabo abangenakho i-lupus.
Imvelo
Izimo zemvelo, nakuba zingabonakali ngokucacile, kuthiwa zingabangela i-lupus kanye / noma i-lupus flares futhi ingafaka:
- Ukuveza ukukhanya kwe-ultraviolet (izithombeensitivity) kusuka kuma-light noma ilanga
- Ukuvezwa ngothuli lwe-silika, etholakala enhlabathini, intuthu kagwayi, ubumbi, nokuhlanza ama-powders
- Ukuveza ukubhema
Izinwele ezithile zezinwele, izibulala-zinambuzane, izihloko, ngisho nokuphuza utshwala kwakukholelwa ukuthi ziyi-lupus, kodwa lokho kungavunyelwe.
Indlela yokuphila
Ukuzikhethela okunye ozizenzelayo, kanye nokuthi uhlangabezana kanjani nezinselele zomzimba nangokwengqondo, kungaba nengxenye ekuthuthukiseni i-lupus. Lezi zici ezintathu zivame ukucatshangelwa:
- Ukucindezeleka, kungaba ngokomzwelo noma ngokomzimba
- Ukukhathala
- Ukubhema
Izingozi Zengozi Yezenhlalakahle
Ukuzala abantwana, ubudala, nobulili yonke ingozi yethonya lokuthuthukisa i-lupus (SLE):
- Umjaho: E-US naseYurophu, amazinga aphakeme kakhulu e-lupus (SLE) abonakala phakathi kwabantu baseSpanishi, base-Asia nabase-Afrika; amazinga aphansi kakhulu abonakala kubantu base-European ancestry.
- Ubudala: Iningi labantu litholakala ukuthi line-lupus phakathi kweminyaka engu-15 no-45, nakuba kungenzeka nganoma yisiphi isikhathi.
- Ubulili: Abantu abayisishiyagalolunye kwabangu-10 abathintekayo abane-lupus bangabesifazane.
I-Genetics
Uma kukhona i-lupus emndenini wakho oseduze, ungase uthathe i-lupus kanye nomthelela ohlobene nalezi zinto ezingenhla. Iningi labacwaningi bayavuma ukuthi izakhi zofuzo noma ubuncwane okungenani kuyisici esisodwa ekunqumeni amandla akho okuthuthukisa i-lupus; Kodwa, ngokwayo, lesi sici kaningi akwanele ukudala i-lupus.
Khumbula-ke, umlando womndeni we-lupus akusho ukuthi uzothola i- lupus, kuphela ukuthi uyingozi kakhulu.
Kuze kube manje, kunezinhlobo zomzimba ezingaphezu kuka-50 ososayensi abaye bazihlanganisa ne-lupus, nakuba kungakaze kuboniswe ukuthi babangela i- lupus, nje ukuthi banganikela.
Indima Yezikhulu Zama-Antigens
I-antigen yinto engena emzimbeni futhi igqugquzele ukuphendula komzimba, ikakhulukazi ukukhiqizwa kwama-antibodies, okulwa nalokho umzimba okubona ukuthi ungumhlaseli. Ama-antigens angathola ama-toxins, amabhaktheriya, amaseli egazi angaphandle, namaseli ezitholwa kabusha. Kuziguli ezine-lupus, ikakhulukazi i-SLE, amasosha omzimba ahlasela ama-antigens ezinamathisini enempilo-okuthiwa ama-auto-antigens noma ama-antigen antigens.
Ngamanye amazwi, ukubekezelelana okuvamile kwalezi zi-autoantigens kuye kwalahleka ezigulini ze-lupus, ikakhulukazi ngenxa yezici zofuzo nezendalo. Kubantu abane-lupus, antibodies eqondiswe kuma-auto-antigens afana ne-DNA kabili-stranded no-Smith (Sm) antigen kuyasiza ekuxilongweni. Lezi zinselo zomzimba ezibhekiswe kuma-auto-antigens zibizwa ngokuthi ama-auto-antibodies.
I-Lupus iyi-systemic, noma umzimba wonke, isifo esizimele esisodwa esihlasela izitho eziningana ezifana nezinso, amalunga, isikhumba, isimiso sezinzwa, amaseli egazi, nemithambo yegazi. Uma enye yalezi zitho ihlaselwa yisistimu yakho yomzimba, izimpawu, nezimpawu ezihlobene naleso sitho zibonakala. Ngokwesibonelo, uma amasosha omzimba akho akhiqiza ama-antibodies ahlasela izinso zakho, izimpawu ezifana namaphrotheni emcinini wakho (ezingabangela umchamo we-foamy), umfutho wegazi ophezulu, kanye / noma ukuphakama kwezinga lakho le-creatinine legazi ngokuvamile livela.
Ukuqaliswa kokuhlaselwa komzimba kuqala ngesistimu yomzimba yokuzivikela ukucabanga ukuthi i-self-antigen (njengeprotheni evamile emzimbeni) into engaphandle nokubi. Ukuqaphela ukuthi i-antigen njengebi emzimbeni wakho kudinga inhlanganisela yezenzakalo, njengezici eziphathelene nokufuyelwa kwezakhi zofuzo kanye nokuqala okukodwa noma ngaphezulu, njengokutheleleka.
Ngamanye amazwi, kuthatha imicimbi eminingi engavamile, eyingozi-isiphepho esiphelele, okushoyo.
> Imithombo:
> I-Fattal I, i-Shental N, i-Mevorach D, et al. I-An Antibody Profile ye-Lupus Erythematosus Eyisistimu Etholwe yi-Antigen Microarray. Immunology . 2010; 130 (3): 337-343. i-doi: 10.1111 / j.1365-2567.2010.03245.x.
> Lee AY, Ang EB. Ukubukezwa Kwemitholampilo yama-Autoantibodies ku-General Practice Rheumatology. I-British Journal ye-General Practice . 2014; 64 (626): e599-e601. i-doi: 10.3399 / bjgp14X681601.
> Lupus Foundation of America. Yini eyenza i-Lupus? Kubuyekezwe ngoNovemba 28, 2016.
> Abasebenzi beMayo Clinic. Lupus. Abasebenzi beMayo Clinic. Kubuyekezwe u-Okthoba 25, 2017.
> Schur PH, Hahn BH. I-Epidemiology ne-Pathogenesis ye-Systemic Lupus Erythematosus. Kusesikhathini. Kubuyekezwe ngo-Ephreli 26, 2017.