Uma ungowesifazane onamazinga aphansi noma aphezulu we-hormone thyrotropin (eyaziwa nangokuthi i- hormone ye-thyroid stimulating , noma i-TSH) unengozi eyengeziwe yokugula kwesifo se-Alzheimer . Ukutholakala kwabikwa encwadini yezokwelapha, i- Archives of Internal Medicine .
Ucwaningo
Esifundweni esikhulu, esenziwa njengengxenye yesiFundo se-Framingham esekelwe emiphakathini, iziguli ezingaba ngu-2 000 zazihlolwa ngezikhathi ezithile ngenxa yesifo sengqondo somqondo ongaphezu kweminyaka eyishumi.
Leli qembu laphinde lalandelwa cishe iminyaka engu-13. Phakathi naleso sikhathi esilandelayo, ama-209 weziguli afundela isifo se-Alzheimer's. Kwabesifazane, amazinga e-TSH ayehlobene kakhulu nesifo se-Alzheimer's. Eqinisweni, kubesifazane abanesisindo se-TSH ngezansi kwe-1.0 noma ngaphezulu kwe-2.1, bekunengozi engaphezu kweyesibili yokwanda kwesifo se-Alzheimer. Ngokuthakazelisayo, akukho buhlobo obufanayo obubonakala kumadoda.
Abacwaningi abazi ukuthi izinguquko ezenzweni ze -roid ne-TSH zenzeka ngaphambi noma emva kokuqala nokuxilongwa kwesifo se-Alzheimer. Futhi abazi indlela yesayense noma yezinto eziphilayo ngemuva kobudlelwane. Kodwa-ke, batusa ukuthi ucwaningo oluqhubekayo luqhutshwe ukuze lunqume ukuthi kunezimpikiswano zokwelashwa noma zokuvimbela.
Mhlawumbe okubaluleke kakhulu ukuthola ukuthi imiphumela yayifana, kungakhathaliseki ukuthi iziguli zitholakala ukuthi zinesimo se -roid futhi zithatha imishanguzo ye-hormone esikhundleni somuthi noma cha.
Isici sokusebenza sibonakala siyizinga le-TSH.
Nakuba i-hyperthyroidism noma i-hypothyroidism elinganiswayo ingabangela izinkinga ezingqondweni, futhi ubunzima ngokukhumbula, ukucabanga, nokufunda, lezi zimpawu kubhekwa ukuthi ziguqulwa ngokuphathwa kahle kwe-thyroid. Kodwa-ke, lolu cwaningo luyinselele imfundiso yendabuko yokuthi izinkinga ze -roid ziyimbangela eguquguqukayo yokukhubazeka kwengqondo.
Esikhundleni salokho, ukutholakala kocwaningo kubonisa ukuthi ukungalingani emsebenzini we -roid kungase kube yinto ebangela ukuba kube yingozi yokuba nesifo se-Alzheimer.
Omunye wabalobi besifundo, uDkt Zaldy Tan, utshele iMedscape:
Kwakujabulisa ukuthola ukuthi amazinga aphansi nephezulu ahlobene nesifo se-Alzheimer. Iqiniso lokuthi ubuchopho buzama ukulondoloza amazinga we -roid ngendlela elula kakhulu kungase kusiphakamise ukuthi ukuze isebenze kahle, kufanele igcinwe ngaphakathi kulolu hlu ukuya ngezansi noma ngenhla lokho akuyona into enhle.
Akucaci ukuthi ngabe amazinga we-TSH abangela i-Alzheimer's, ukuvikela ngokumelene ne-Alzheimer's, noma ngabe isifo se-Alzheimer ekugcineni sithinta i-TSH. Ucwaningo lwaluyinkimbinkimbi futhi aluzange luhlole ukuthi kwenzekani. Ochwepheshe bathi inhlonipho yokuziphendulela ingalimazwa yi-Alzheimer's disease, noma ukuthi ukungabi namakhemikhali e-thyroid kungase kube nomthelela ekwenzeni isifo se-Alzheimer's.
Umbono owodwa othakazelisayo ngababhali bokutadisha ubheka indima ihomoni ye-thyroid edlala ekulawuleni inkulumo yegesi okuthiwa i-amyloid procuror protein (APP), enendima e-Alzheimer's. Kungenzeka ukuthi ukungalingani kwe-hormone ye-thyroid kungabangela izinkinga ngokulawulwa kwe-APP, ngaleyo ndlela kwandisa ingozi ye-Alzheimer's.
Ukutadisha okuqhubekayo ebuhlotsheni phakathi kwe-thyroid, amazinga e-TSH, nesifo so-Alzheimer kuyadingeka. Ucwaningo olunjalo lungase luphelele ukunikeza izizathu ezizwakalayo zomphakathi wezokwelapha ukuze ekugcineni zithole uhlu oluthile lokubhekisela lwe-TSH.
Le mpikiswano inengxabano. Ngo-2002, i-American Association of Clinical Endocrinologists (AACE) yakhuthaza ukunciphisa ububanzi besithenjwa se-TSH kusukela ku-0.5 kuya ku-5.0 mIU / L, ngokuvamile ku-0.3 kuya ku-3.0, kanti iNational Association of Clinical Biochemistry yanconywa phezulu umkhawulo we-2.5. Ngenkathi abanye odokotela kanye ne-endocrinologists bekhuthaza izincomo, i-AACE yashiya le ncomo, futhi ama-laboratories kanye nodokotela basacubungula ukuhlolwa kwegazi le-thyroid ngokusho kobudala obuphakathi kuka-0.5 no-5.0.
Izwi kusuka
Okwamanje, lolu cwaningo lunikeza ubufakazi obengeziwe bokuthi, iziguli ezithola ukwelashwa kwe-thyroid, uhla lwamathenda wezinga eliphezulu le-TSH ngenkathi imishanguzo kufanele ibe phakathi kuka-1.0 kuya ku-2.0, ngaphandle uma kunezinye izici ezisheshayo ezihilelekile. (Isibonelo, ezinye iziguli zomdlavuza we-thyroid zigcinwa emithini yokucindezela imithi yegciwane, ukugcina izinga le-TSH liphansi kakhulu, noma ngezinye izikhathi ligxiliwe kumazinga aseduze no-0, njengendlela yokuvimbela ukuphindaphindiwe komdlavuza wegciwane.
> Umthombo:
> I-Tan, i-Zaldy et. al. Umsebenzi we-Thyroid kanye Nengozi Yokugula Kwe-Alzheimer: Isifundo Se-Framingham. " I-Archives of Medicine yangaphakathi , 2008; 168 (14): 1514-1520.