I-Lymphoma yigama elijwayelekile lezinhlobo eziningi ezihlobene nomdlavuza ezivela ku-lymphocytes. Izigaba ezimbili ezinkulu ze-lymphoma yi- Hodgkin lymphoma (HL) ne-non-Hodgkin lymphoma (NHL) .
I-Mantle cell lymphoma (i-MCL) ingenye yama- subtypes amaningi e-NHL . Ngokuqondile, yi-non-Hodgkin lymphoma evela kuma-B-lymphocytes.
Izibalo ze-MCL
- Kuyinto engavamile - e-US, cishe amaphesenti ayisithupha we-non-Hodgkin lymphomas yi-MCL.
- Kuvame ukuthinta amadoda ngaphezu kwabesifazane.
- Kuvame ukuthinta labo abangaphezu kweminyaka engama-50 ubudala, abaneminyaka yobudala ehlongozwayo phakathi neminyaka engama-60.
Izimpawu
- Izimpawu zifana nalezo ezinye izinhlobo eziningi ze-NHL , ngoba uphawu oluvame kakhulu lunye noma ngaphezulu lymph nodes engenabuhlungu .
- Izimpawu ezijwayelekile ezifana nokujula ebusuku, imfiva , nokulahleka kwesisindo okungenasisekelo nakho kungenzeka.
- I-MCL ingasakazeka emathunjini, futhi uma lokhu kwenzeka, kungabangela izimpawu ezifana nesifo sohudo kanye nobuhlungu besisu.
Ukuthungatha nokuhlola
I-MCL ibukeka njenge-low-grade lymphoma ngaphansi kwe-microscope, ngokusho kwe-CancerResearchUK, kanye ne-low-grade lymphomas inezakhi ezibukeka sengathi zinamaseli avamile; Kodwa-ke, i-MCL ingaziphatha ngendlela efana ne-high-grade lymphoma, ekhula ngokushesha. Amangqamuzana e-Lymphoma angase asakazeke ngesikhathi sokuxilongwa - emantanjeni omzimba , emnothweni wethambo kanye nesipen.
Ukwelashwa Nemiphumela
I-Chemotherapy ehlangene namanye ama-agent asetshenziselwa ukuphatha i-MCL.
Kusetshenziselwa inhlanganisela eminingi ye-chemotherapy kanye ne- rituximab (Rituxan) . I-Bortezomib (i-Velcade) ingasetshenziselwa ukwelapha iziguli ezibuyiselwe izifo futhi zamukelwe iziguli ezingelashwa ezikwelapha. I-Ibrutinib (Imbruvica) ivunyelwe iziguli ezine-MCL ephindaphindiwe .
Ukwelashwa akuvamile uma ungatholakali . Inhloso yokwelashwa ukugcina lesi sifo silawulwa isikhathi eside ngangokunokwenzeka.
Kodwa-ke, i-MCL yinkinga yezivivinyo eziningi eziqhubekayo zokwelapha ukutadisha ukuthuthukiswa okungaba khona kokwelapha.
Kungani Kuthiwa I-Mantle Cell Lymphoma?
Uma uzwa igama lezingubo, mhlawumbe ucabanga ngalowo mgwaqo ngaphezu kwendawo yokushisa lapho izithombe zomndeni kanye nama-tchotchke zivame ukugcinwa. 'Isigqoko' se-mantle cell lymphoma sidonsela incazelo ehlukile - okubhekisela kwengubo noma shawl; kungase kube isenzo, ukugqoka noma imvilophu - njengokuthi "ezintabeni ezinzima zanyakaza amahlumela asehlathini."
'Isigqoko' esitokisini se-mantle cell lymphoma ekuqaleni sibhekisela endaweni yamaseli okucatshangwa ukuthi ahilelekile ngokuyinhloko ekubulaleni. I-Mantle cell lymphomas yayihlotshaniswa ne-mantle zone ye-lymph node follicles - amaseli azungeze futhi agubuze okuthiwa isikhungo se-germinal, futhi konke lokhu kuchazwa ngokuningiliziwe esigabeni esilandelayo.
I-term mantle cell lymphoma yakhiwa ngawo-1990 ukubhekisela kwisethi ethile ye-lymphomas ene-genetic rearrangement, futhi namuhla kucatshangwa ukuthi kuphela i-subset ye-mantle cell lymphomas inomzimba omkhulu, owuphawulekayo lomdlavuza. I-MCL ingaba nemibono ehlukahlukene ebonakalayo ngaphansi kwe-microscope, kodwa ukubandakanya kwesigcawu sezingubo ze-follicle kuchaza umsuka wegama.
I-Follicle ne-Mantle
Isithombe esiboniswe phezulu kwalesi sihloko siyingxenye yesiphambano, noma ingxenye eyodwa ngokusebenzisa i-lymph node yonke, njengoba kubonakala besebenzisa i-microscope elula ekukhuliseni amandla okuphansi. Lesi sigaba senziwe futhi sigqoke isilayidi silazi ukuze ubone izinhlobo ezahlukene zamaseli nokuthi zihlelwe kanjani ngaphakathi kwe-node.
Imibuthano emnyama noma izivalo ozibonayo ukutadisha i-lymph node - ikakhulukazi ngasekupheleni kombono-kuthiwa yi-follicles. Ifollicle ifomu lymph nodes, kanti futhi ingaba nezicubu ze-lymphoid kwezinye izingxenye zomzimba. I-follicle ngayinye emfanekisweni ongenhla igcwele ama-B-cells, noma i-B-lymphocyte, ehlobo lwegazi elimhlophe.
Kuye lapho lezi ziseli ze-B zitholakala khona ngaphakathi kwe -follicle, zingase zibe nemisebenzi ehlukile.
Uma ubheka ngokucophelela ama-follicles, ungase ukwazi ukubona ukuthi amanye awo aphukile phakathi nendawo obomvu okwesibhakabhaka ngaphandle . Isikhungo sokukhanya siyaziwa ngokuthi isikhungo semvelo se-follicle kanti i-darker out isaziwa ngokuthi i-mantle.
B-amangqamuzana angavuthwa ukwenza ama-antibodies ahlanganisa 'amathegi,' noma ama-antigens, kubahlaseli njengama-bacteria. Ngenkathi isikhungo semilenze ephazimulayo sinama-B-amangqamuzana akhula ngokuqhubekayo ukuze enze ama-antibodies ayohlosa ama-antigens kwabahlaseli, indawo ebophekile yengubo yenziwa ngamaseli e-B aphumayo nalabo abanakho 'inkumbulo' yama-antigen abhekene nabahlaseli abadlule .
Imiphumela ye-MCL lapho i-B-lymphocyte engqenqemeni yangaphandle ye-lymph node follicle - indawo yezingubo - iguqulwa, noma iyingozi. I-B-lymphocyte eguquliwe ikhula ngendlela engalawuleki, okuholela ekuqongeni kwamangqamuzana e-lymphoma, okubangela ukwandiswa kwama-lymph nodes.
Imithombo:
I-Cancer Research UK. I-Mantle Cell Lymphoma.
I-Leukemia neLymphoma Society. Imininingwane ye-Mantle Cell Lymphoma .
I-Non-Hodgkin Lymphomas, ehlelwe nguJames O. Armitage, uBertrand Coiffier. ULippincott Williams & Wilkins, uNomb 1, 2009.