Isifo sika-Parkinson sithinta ubuchopho namaseli ayisisindo futhi ngokuvamile kubangela izinkinga ngokunyakaza kwemisipha; I-leukemia uhlobo lomdlavuza oluthinta umongo wegazi kanye negazi. Isifo sikaParkinson sinqabile kakhulu ezinganeni; kuyilapho i-leukemia ingumdlavuza ovame kakhulu. Kungenzeka kanjani lezi zifo ezimbili ezihluke kakhulu?
Yebo, abantu abaneParkinson kanye nabantu abane-leukemia bahlanganyela kakhulu-okuwumthwalo wokubhekana nesifo sabo. Ngokwemvelo, noma kunjalo, izincwadi zesayensi zinikezela ezimbalwa eziholela ekuthandekayo kulabo abafuna ukungafani phakathi kwezi zifo ezimbili.
Isidakamizwa se-Leukemia sibonakala sinciphisa izimpawu zikaParkinson
I-Tasigna (nilotinib) yisidakamizwa esivunyelwe ukuphatha izinhlobo ezithile ze-leukemia. Ngokusekelwe eqenjini elincane kakhulu labahlanganyeli bezocwaninga, i-nilotinib ibonakala ukunciphisa izimpawu kubantu abanesifo se-Parkinson nesifo sengqondo sokugula komqondo noma i-Lewy yomqondo wengqondo yomzimba.
Ngokombiko we-NPR, ukuhlolwa kweziguli ezingu-12 ezanikezwa ngamanani amancane ka-nilotinib bathole ukuthi ukunyakaza nokusebenza kwengqondo kuthuthukiswe kubo bonke abantu abangu-11 abaqedile ukuhlolwa kwezinyanga eziyisithupha. Abacwaningi babike lokhu okutholwe eNhlanganweni yoMhlangano we-Neuroscience eChicago. Isifundo esincane kakhulu, asiklanyelwe ukukala ukusebenza futhi kwakungekho ukubalwa komphumela we-placebo.
Noma kunjalo, lokhu okutholakele kwakusithakazelisa kakhulu futhi kuzokwenza ucwaningo oluthe xaxa.
U-Nilotinib ungowesiqhema semithi eyaziwa ngokuthi i-kinase inhibitors. Ngokuqondile, i-nilotinib iyisimiso se-BCR-ABL kinase. Ama-Kinase namanye ama-enzyme, ama-GTPase, awagcini nje ngokucindezeleka kwezinzwa, kodwa futhi ahlotshaniswa nezinye izifo zomuntu ezihlukahlukene ezifaka umdlavuza nezimo zokuvuvukala.
Ngenkathi isidakamizwa singenzelwe isifo sikaParkinson, akuyona into engacabangeki ngokwesayensi ukuthi ingase ibe nomthelela ongenakulindelekile walesi sifo.
Amanzi Okuphuza Amanzi Ahlanganisiwe Kuzo zombili
Ucwaningo olunyatheliswa encwadini ka-Agasti 2014 ethi "Environmental Health," yasebenzisa iqiniso lokuthi amanye amanzi okuphuza e-US Marine Corps Base Camp Lejeune, eNorth Carolina, ayengcoliswa yi-solvent phakathi nawo-1950 kuya ku-1985. iqembu labacwaningi lihlolisise imiphumela yalokhu kuvezwa ngengozi ngokuqhathanisa izimbangela zokufa phakathi kwabasebenzi eKamp Lejeune neCamp Pendleton, lapho amanzi ahlanzekile khona.
Kuyinselele ukuxazulula imbangela nomphumela uma ubuka emuva, futhi imiphumela yalolu hlobo lokutadisha ihunyushwa ngokucophelela. Kodwa-ke, kulolu cwaningo, kubonakala kunengozi enkulu yokufa ehilela izifo ezihlukahlukene, kuhlanganise nomdlavuza wezinso, i-leukemia, i-myeloma nesifo sikaParkinson phakathi kwabasebenzi abaye bavezwa eCamp Lejeune.
Ukuvezwa kwezidakamizwa ezixhunywe Kuzo zombili
Amacala amaningi e-Parkinson's and leukemia akholelwa ukuthi athuthuka ngendlela ehlukahlukene, okungenzeka kube nokuchayeka kwemvelo okuhlukahlukene kanye nezakhi zofuzo ezahlukene ezihilelekile.
Ukutadisha ukuthuthukiswa kwezifo ezinjalo ngokuqondene nesici esisodwa, futhi ukwenza kanjalo kubukeka emuva emuva kwesikhathi kunzima kakhulu. Noma kunjalo, kukhona ukuxhaswa kokuxhumanisa phakathi kwezibulala-zinambuzane, ukubulala ukhula kanye ne-toxic kanye kokubili kwesifo se-leukemia nesifo sika-Parkinson. Ngokusho kocwaningo olwenziwe ngo-May 2013 lwephephandaba i- Neurology , izincwadi zesayensi zisekela umbono wokuthi ukuchazwa kwezibulala-zinambuzane noma i-solvents kuyinto engozini ye-Parkinson, kodwa ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe ubudlelwane obangela imbangela. I-Paraquat (paraquat dichloride, noma i-methyl viologen), isibonelo, i-herbicide ebhekwe njengengozi engcupheni yesifo sika-Parkinson.
Ngokufanayo, iqembu labacwaningi eCosta Rica lazama ukutadisha ubudlelwane phakathi kwabazali ababevezwe ezibulala izinambuzane kanye nobungozi bokuthi abantwana basuke benesifo sengculaza ezinganeni zabo. Ngenkathi bekungenakukwazi ukubeka eceleni ukuthi kungenzeka ukuthi akukho miphumela emikhakheni eminingi abayicubungulayo, babone umkhuba wokwandisa ingozi ye-leukemia yobuntwana ngokutholakala kwe-pesticide-ikakhulukazi ukuvezwa komama kuma-pesticides ngesikhathi sokuqala kokuqala kokubili kokukhulelwa.
Imithombo:
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