Ubuchwepheshe obusha be-polymer bwenza isikhumba sesikhumba esingcono
Yonke into eyenziwe entsha noma ukuphumelela ngendlela ethile iveza umsuka wayo emsebenzini wabanye. Imithi emisha kanye nokwakhiwa okusha kwemithi akufani. Uma ukwazi ukuthuthukisa ekwakhiweni komunye usosayensi, futhi kusengaphambili ukuphumelela kwakho, okulula kakhulu futhi okuphephile, kungenzeka ukuthi uye kwenye into.
Muva nje, eziningi ze-hype ziye zazungeza izindaba zesikhumba esisha se-ibuprofen esakhiwa ngabacwaningi eNyuvesi yaseWarwick kanye nenkampani yabo engaphansi kwayo iMedherant.
Ngokusobala, lolu hlelo lokulethwa kwe-patch lungcono kakhulu, luyinkimbinkimbi encane futhi lunikeza imithi ngokulinganayo kunanoma yini esingakabi nayo emizimbeni yethu.
Kuyini i-Ibuprofen?
U-Ibuprofen (cabanga ngo-Advil noma i-Motrin) yi- NSAID (isidakamizwa esingavumeli ukuvuvukala) esingavimbela ukuthi i-cyclooxygenase-1 (COX-1) ne-cyclooxygenase-2 (COX-2) enzyme iphazamise ukukhiqizwa kwe-prostaglandin. Ngokuphazamisa i-prostaglandin synthesis, ibuprofen isiza ukunciphisa ubuhlungu, ukuvuvukala nomkhuhlane. Inothi, amanye ama-NSAID afaka i-aspirin ne-naproxen.
Ochwepheshe balingisa ukuthi ngaphezu kokuphazamisa ukukhiqizwa kwe-prostaglandin, ibuprofen ingase futhi ilwa nokuvuvukala ngokuthinta igazi ngezinye izindlela, kuhlanganise nokuguqulwa komsebenzi we-lymphocyte, ukuvimbela i-chemotaxis, ukuvinjelwa kwe-neutrophil aggregation noma ukusebenza, nokunciphisa amazinga we-cytokine asezingeni eliphansi.
Yini Ibuprofen Eyisebenzisayo?
Ibuprofen isetshenziselwa ukunciphisa umkhuhlane kanye nokuphatha izinhlungu nezinhlungu ezihlukahlukene, njengalezo ezibangelwa ikhanda, ukulimala emuva, i-arthritis, amazinyo nokuya esikhathini.
Ngokuthakazelisayo, ama-NSAID afana ne-ibuprofen ayenempilo kakhulu ekuphatheni ubuhlungu bezinso zezinso. Ngaphezu kwalokho, ibuprofen ingahlanganiswa nama-opioid (njenge-hydrocodone) ukuphatha ubuhlungu obukhulu.
Ibuprofen Iphathwe Kanjani?
Kukhona imizila ehlukahlukene yokuphatha ibuprofen, kuhlanganise amaphilisi, injection, nama-gel.
Ukuphathwa kwe-ibuprofen nge-patch kuyinveli futhi kungcono kunesicelo se-topical usebenzisa ama-gel. Ama-gel Ibuprofen ahlambalaza futhi awaphuli imithi njalo.
Nazi ezinye izinzuzo ezihlongozwayo ze-ibuprofen kanye ne-polymer technology ephakeme:
- Ubuchwepheshe obusha buvumela ukuthi i-patch ilayishwe imithi emihlanu kuya kwezi-10 ngaphezulu. Ngamanye amazwi, amaphesenti angu-30 wesisindo se-patch yimithi yangempela.
- Ukukhululwa kwemithi emzimbeni kuyahambisana futhi kungasebenza kuze kube amahora angu-12. Njengamanje, abantu abanezibalo eziphezulu ze-ibuprofen bangadinga ukugwinya amaphilisi njalo emahoreni amane.
- I-patch yinkimbinkimbi kakhulu, iguquguqukayo, ikhululekile futhi iqondakali kunamanye ama-patches. Ngaphezu kwalokho, lesi siqeshana sishiya indawo encane futhi sincane futhi sincane.
I-ibuprofen patch yenzelwe ukusebenzisa ubuchwepheshe obusha be-polymer obudalwa inkampani ebizwa nge-Bostik futhi ilayisensi yokusetshenziswa kwe-Transdermal ngu-Medherant.
Izicelo ezinokwenzeka ze-Patch entsha zingaba umdlalo-ukuguqula
Ngokusho kweMedherant, amaningi amaningi okusizwa ubuhlungu obukhona okwamanje akanayo imithi ye-painkiller futhi esikhundleni sokushisa ukushisa (cabanga menthol). Ngakho-ke, lawa ma-patches endala anqunyelwe ekusebenziseni kwawo. I-ibuprofen epatch entsha ye-Medherant iyinhlangano ngezindlela eziningana.
Okokuqala ngoba isiqephu singavamile, sisebenzise isikhathi eside futhi sisebenziseka kalula, cishe sizosiza ikakhulukazi iziguli ezithile ezifana nabagijimi nabantu abanezinkinga zokunamathela kwezidakamizwa . Isibonelo, umgijimi angasebenzisa isiqephu endaweni yenkinga noma ukulimaza nokusebenza kwamahora, noma umuntu othola imithi eminingi angase abe namaphilisi amancane angakhathazeka ngawo.
Okwesibili, ngokudlula isisu nokukhipha imithi eqondile esikhumbeni, i-ibuprofen patch ngeke ivuseleleke isisu, umphumela omubi ovamile kulabo abanobukhulu obuphezulu be-NSAID yomlomo.
Okwesithathu, ubuchwepheshe obusetshenziselwa ukuthuthukisa le patch kungenziwa ukhethe ukuletha ezinye izinhlobo zemithi-imishanguzo, efana ne-ibuprofen, eyayingenakugwenywa ukuphathwa kwe-patch. Okuphawulayo, ezinye izinkinga zokuphuza ubuhlungu nazo zenziwa ngendlela efana ne-fentanyl (i-opioid) ne-lidocaine (i-antichetic), futhi kuyothakazelisa ukubona ukuthi ngabe ubuchwepheshe obusha be-patch bungayithuthukisa ukuphathwa kwezidakamizwa.
Ingabe Ibuprofen Inemiphumela Emibi?
U-Ibuprofen uthengiswa phezu kwe-counter futhi ingozi yemiphumela emibi iphansi. Ukucasuka kwesisu kungumphumela omubi kunazo zonke we- NSAID njenge-ibuprofen. Eminye imiphumela emibi ye-ibuprofen ihlanganisa ukuphuma (njengokuphuza ubuchopho noma ukushaywa umoya) kanye nokucasuka kwesilonda.
Hlola lesi sihloko mayelana nokuthi ama-NSAID axhunyaniswe kanjani nezivivinyo ezingavumelekile ezinganeni.
Njengoba kukhulunywe ngaye ngaphambili, abenzi be-ibuprofen patch entsha bathi nge-patch yabo, akuyona ingozi yokumangala ngesisu ngoba imithi itholwe yisikhumba hhayi ngegciwane lesisu.
Kodwa ezimweni ezingavamile, ibuprofen ingabangela ukuqhuma okubi, imihlathi kanye nezinye izici zesikhumba. Abantu abanomlando we- atopy , noma labo "abanama-hyperallergic" futhi abanenkinga ye-eczema, i-fever fever kanye ne-asthma ye-allergen, kungenzeka ukuthi bayagula ibuprofen. Noma kunjalo, abantu abangenalo i-atopy baye bahlakulela ukungezwani komzimba ku-ibuprofen.
I-pipeline ye-ibuprofen ikude kakhulu nokushaya imakethe futhi kusadingeka ibe i-FDA evunyelwe. Kuze kube manje, kukhona ukucwaningwa okuncane okushicilelwe kulesi siqephu-iningi lalokho esikwaziyo livela emithonjeni yezindaba, izingxoxo kanye nemibiko yemidiya-futhi sizodinga ukubona idatha yangempela ngaphambi kokuba siyiqonde ngempela lokhu kukhishwa okusha. Isibonelo, akucaci ukuthi ngabe inani elikhulayo kanye nokugcinwa kwezihloko eziqhubekayo ze-ibuprofen patch kungaholela ngandlela-thile ukukhulisa isikhumba kulabo abaphikisayo kuma-NSAID.
Ukubheke phambili, uMedherant, umenzi we-ibuprofen patch, ulindele ukuthi uhlelo lwayo lwe-drug-delivery delivery system luzosetshenziselwa ukuphatha ezinye izidakamizwa kanye neziphequluli ezingaphezu kwamakhomithi eziningi ezazingatholakali ngaphambili kwifomu lokubamba iqhaza. Isibonelo, i-Medherant ihlola isitifiketi se-methyl salicylate. (I-Methly salicylate iyisithako esikhulu esisebenzayo ku-BENGAY.)
Imithombo
Isihloko esibizwa ngokuthi "I-hypersensitivity-type type hypersensitivity" ephuma ku-ibuprofen "ngu-E Nettis kanye nabalobi ababambisene nabo abashicilelwe ngo-2004.
Ukungena okubizwa ngokuthi "Ibuprofen" kusigaba seDrug Monographs se-Access Medicine.