I-Benfotiamine ifomu elenziwe ngumuntu we-thiamine noma i-B1. I-thiamine iyi-vithamini engenawo amanzi futhi ngakho-ke ayisetshenziswa kalula ngomzimba. I-Benfotiamine iyakhiwa ngokuncibilika kwamafutha futhi ingcono futhi iyasetshenziswa. Kube nobufakazi bokuthi i-benfotiamine ingasiza ekunciphiseni ukucindezeleka kwesifo sikashukela njengokwakheka kwe-retinopathy, nephropathy, kanye neuropathy.
- Kuyini ukubuyiswa kwesifo sikashukela?
- Iyini i-Diabetes Nephropathy?
- Kuyini ukuhlinzekwa kwesifo sikashukela?
I-Benfotiamine ye-Diabetes Neuropathy
I-Benfotiamine iye yafunda izifundo eziningana eminyakeni yamuva. Okugxilwe ngokuyinhloko kwezifundo kuhilela ukusebenzisa i-benfotiamine njengokwelashwa kwezinkinga zesifo sikashukela.
Izinkinga eziningi zesifo sikashukela zibangelwa i-hyperglycemia ende (ushukela ephezulu wegazi) ngenxa yegazi elingenakulawulwa kwegazi noma ukuqhubeka kwezifo ngokuhamba kwesikhathi. I-glucose ngokweqile egazini ifakwe emangqamuzaneni omzimba kanye nemithambo encane yegazi emaphethelweni, okwenza kube nomonakalo kulezi zindawo ezibangelwa izimpawu nezinkinga zezinkinga.
Izindlela Ezinhlanu Zokulimala Kwamaselula
Kunezindlela ezine ezihlukene ezivela emzimbeni ongabangela ukulimala komkhumbi omncane wegazi ngenxa ye-hyperglycemia yesifo sikashukela.
- Imikhiqizo yokugcina ye-glycation (AGE)
- Amaprotheni kinase C (PKC)
- Ukuqalisa ukusebenza kwe-Hexosamine
- Ukuqalisa ukusebenza kwe-Polyol
I-Benfotiamine ibonakala ivimbela ezintathu kulezi zindlela ezifundweni zemitholampilo. I-athikili, eyabonakala encwadini ethi Nature Medicine ngoFebruwari 2003, ebizwa ngokuthi "iBenfotiamine Blocks Three Ways of Hyperglycemic Damage and Prevents Retinopathy", yabonisa ukuthi i-benfotiamine ivimbele ukuphindaphinda kwesifo sikashukela ezilwaneni zase laboratory.
Imikhiqizo Ephezulu Ye-Glycation End
I-hyperglycemia ibangela ukulimala emithanjeni yegazi kanye nemisipha yomzimba, okuzobe yinto yaba nezinkinga ezinkulu zesifo sikashukela. Ukulimala kwenzeka uma i-glucose ngokweqile egazini ihlelwa emangqamuzaneni bese yenza i-substance eyaziwa ngokuthi i-endroducation ekupheleni kwe-glycation (AGE) Lezi ziqoqa ngokuhamba kwesikhathi. Ama-AGE atholakala ezitheni zamehlo, izinso, kanye nemikhawulo. Zitholakala nakweminye imikhakha yegazi enkulu futhi ziholele ekubunjweni kwe-plaque kanye ne-atherosclerosis, okufaka isandla esihlokweni senhliziyo.
Yenzani i-Benfotiamine
Ucwaningo lubonise ukuthi i-benfotiamine ibonakala ibasiza ekuvimbeleni izinkinga ze-neuropathy, i-retinopathy, ne-nephropathy ngokuvimbela ukwakheka kwe-glucose ezitsheni. Lokhu kusho ukuthi ukutholakala kwezinkinga zesifo sikashukela kunganciphisa noma kuvinjelwe. Ucwaningo olwenziwe emtholampilo oluvela encwadini ye-ADA lweSifo sikashukela ngo-2003 lubonise ukuthi i-thiamine ne-benfotiamine ephakeme kakhulu ibonakala ivimbela i-microalbuminuria neproteinuria (amaprotheni emcinini) ezinkingeni zesifo sikashukela. Izifundo ezenziwe kubantu ziye zabonisa ukuthi i-benfotiamine ibonakala iphinde ikhulise ubuhlungu be-neuropathic.
Isimo samanje seBenfotiamine
I-Benfotiamine isesigaba sesilingo sesilingo. Lezi zifundo zenzelwe ikakhulukazi kumagundane aphethwe ukuba abe nesifo sikashukela.
Ukuhlolwa okunamandla kuyadingeka ukucacisa ukuthi i-benfotiamine isebenza ngendlela efanayo kubantu abanesifo sikashukela. Izinga eliphumelelayo alikaze lisungulwe, futhi imiphumela emibi yesikhathi eside ayaziwa.
Nakuba i-benfotiamine ayinconywa ngokusemthethweni ngabasebenzi bezempilo baseMelika ngalesi sikhathi, kubonakala sengathi kungase kube ukwelapha okuthembisayo kokucindezeleka kwesifo sikashukela ngaphansi komgwaqo.
Ukwamukelwa kusalindiwe yi-FDA
Ukuphathwa Kwezokudla Nezidakamizwa (FDA) okwamanje akukaze kuvunyelwe i-benfotiamine ukuze kusetshenziswe umphakathi. Kukhona izingxabano mayelana nokuthi lo muthi kufanele ubhalwe kanjani, kungakhathaliseki ukuthi isondlo sokudla noma i-vitamin.
Kukhona ukukhathazeka mayelana nokuphepha jikelele kokusetshenziswa kwesikhathi eside kwe-benfotiamine nokuthi yini eyenza isilinganiso esiphephile. I-FDA idinga ubufakazi obengeziwe bokuthi i-benfotiamine ikhiqiza imiphumela ebonwe kuzilingo.
Ngonyaka odlule, i-benfotiamine ithunyelwe ku-FDA njengesengezo sokudla, kepha ukuvunywa kulindile ngalesi sikhathi.
- I-FDA I-Response Letter Yokuhambisa iBenfotiamine njengeNsiza Yokudla
Imithombo:
> Haupt, E., Lederman H., Kopcke W. "Benfotiamine ekuPhilweni kweDiabetes Polyneuropathy - isifundo sePiyona Elawulwa Ngamaviki amathathu. I-International Journal of Clinical Pharmacology, Therapy and Toxicology Jun 2005: 304. PubMed.gov. I-Library Yomphakathi Yomuthi kanye Nezikhungo Zikazwelonke Zempilo. 09 Mashi 2007.
> Huebschmann, MD, Amy G., Regensteiner, Ph.D., Judith G., Vlassara, MD, Helen, Reusch, MD, Jane EB "Isifo Sikashukela kanye Nemikhiqizo Ekupheleni Ye-Glycoxidation." Ukunakekelwa yisifo sikashukela ngo-2006 1420-1432. 09 Mashi 2007.
> Melpomemi >, MD, uPeppa, Uribarri, MD, Jaime, noVlassara, MD, uHelen. "I-Glucose, Imikhiqizo Ephezulu Yase-Glycation End, Nezifo Zokuhlukunyezwa KaShukela: Kuyini Okusha Nalokho Okusebenzayo." Isifo sikashukela soMtholampilo 2003 186-187. 09 Mashi 2007.
> Nxusa, MD, Alin, Negrean, MD, Monica, Stratmann, > PHD >, Bernd, Gawlowski, MS, Thomas, Horstmann, Tina >> Gotting >, > PHD >, Christian, Kleesiek, MD, Knut, Mueller-Roesel , MD, Michaela, Koschinsky, MD, Theodor, Uribarri, MD, Jaime, Vlassara, MD, uHelen noTschoepe, MD, Diethelm, "UBenfotiamine Ivimbela Ukukhubazeka Kwe-Macro- kanye ne-Microvascular Endothelial Nokucindezeleka Okuxubile Ukulandela Ukudla Okunamandla KuMikhiqizo Ekupheleni Ye-Glycation End ku-Individual with Type 2 Diabetes. " Ukunakekelwa yisifo sikashukela 2006 2064-2071. 13 Mashi 2007.
> "Izidakamizwa Zokuphatha Izinkinga." Ukusuka Ucwaningo Kuya Eqinisweni. 2005. I-Juvenile Research Diabetes Foundation International. 18 Mashi 2007.
> Hammes, Hans-Peter, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. "I-Benfotiamine Blocks Iindlela Ezinkulu Ezinhlanu Zokulimala Kwe-Hyperglycemic futhi Ivimbela Ukuthambekela Kwe-Diabetes Okuhlolisayo." Nature Medicine, 18 Feb. 2003 294-299. 18 Mashi 2007.