Ngesinye isikhathi noma sonke, sonke sine-chuckle emihle ngemithi yokuphuza erectile efana ne-sildenafil (i-Viagra) ne-tadalafil (Cialis). Kodwa kuncibilikisa njengoba singakwenza, le mithi iphumelela ngokuphumelelayo ekusizeni amadoda anezinkinga zokuhlukunyezwa ngokocansi kanye ne-erectile. Ucwaningo olusha nemikhombandlela yomtholampilo kusikisela enye ukusetshenziswa kule mithi: ukuphathwa ngokubambisana nezidakamizwa ezifana ne-finasteride (i-Proscar) noma i-dutasteride (i-Avodart), okuyi-5-alpha-reductase inhibitors esetshenziselwa ukuphatha i-benign prostatic hyperplasia (BPH).
Ngokuqondile, ama-inhibitors ama-5-alpha-reductase nama-alpha blockers, olunye uhlobo lwezidakamizwa ze-BPH, yenza inombolo e-libido yomuntu kanye nekhono lokugcina ukulungiswa - umphumela omubi ophikisana nama-erectile disys functional like Cialis. Ngaphezu kwalokho, ngo-2011, i-FDA evunyelwe i-Cialis yokwelapha izimpawu ze-BPH, futhi (cabanga ukuthi kunzima ukuchama). Ngakho, i-Cialis inenzuzo kabili kulabo abane-BPH!
Kuyini i-Benign Prostatic Hyperplasia (BPH)?
Uma unayo i-BPH, cishe awudingi isingeniso kumpawu zayo ezingathandeki, ezicasulayo futhi ngezinye izikhathi ezinzima kakhulu. Kodwa-ke, sonke esingaziwa, nansi ulwazi ngalesi simo.
I-Benign prostatic hyperplasia yindlela yokukhulisa i-prostate gland engeyona engavamile. Emadodeni, i-prostate yenza isisu. Emadodeni ane-BPH, i-prostate ingaba yikhulu izikhathi ezingu-10 futhi ibangele ukuvimbela umchamo. Inothi, i-prostate iyinhlavu efana ne-donut ezungeza i-urethra noma i-"pee" tube; i-prostate ihlezi ngaphansi kwesisindo.
Nakuba umdlavuza we-prostate uhlanganisa futhi hypertrophy kanye hyperplasia kanye eziningi izimpawu zokuqala ezifana BPH, BPH akuyona umdlavuza. Isimo esibucayi abantu abaningi abaneminyaka yobudala engama-50 noma ngaphezulu ngezinga elithile. Ngaphezu kwalokho, cishe i-BPH ayinikeli ingozi eyengeziwe yokwenza umdlavuza wesi-prostate.
Emadodeni amaningi, i-BPH ayinakuqhathaniswa futhi ayibangeli izimpawu ezibonakalayo Ngomunye wesithathu wamadoda aseMelika, noma kunjalo, angathola izimpawu zokuqala ezilandelayo:
- Isifiso esiningi sokuvuthwa (imvamisa yamanzi) ikakhulukazi ebusuku
- Ukusakaza komchamo obuthakathaka okuqala nokuyeka
- Uzwa ukuthi usadingeka ukuthi uphelele ngisho nangemva kokuba usuqedile ukuvota
- Inkinga eqala ukusakaza komchamo (ukungabaza)
- Ukuthinta igazi egazini
Ngokuhamba kwesikhathi, i-BPH ingaholela ezinkingeni ezingathi sína ezinjenge-urinary tract infections, i-kidney, kanye nomonakalo wesinye. (Ukuvinjelwa okubangelwa isicathulo se-hyperprolastic kungabangela isipele se-urine esilimaza izinso nesinye.)
Ukwelashwa kokuqala kwe-BPH yizokwelapha nokuhlinzwa ( TURP ) egcinelwe abantu abahluleka ukulwa nemithi. Amadoda ane-BPH anezimpawu ngokuvamile athola izinhlobo ezimbili zemithi: i-alpha blockers (cabanga nge-terazosin noma i-doxazosin) ne-5-alpha reductase inhibitors njenge-Proscar ne-Avodart eshiwo ngenhla.
Umfundi ohlakaniphile angase aqaphele ukuthi zombili izinhlobo zemithi ye-BPH iqukethe i- alpha ngamagama abo; Kodwa-ke, izindlela zalezi zidakamizwa zihluke ngokuphelele. Ama-Alpha blockers aphumule imisipha ekhanda emqaleni entanyeni nasesithombeni ukuze kuthuthukiswe ukugeleza komchamo nokunciphisa ukuvinjelwa kwamanzi. Nakuba-ke, ama-inhibitors ama-5-alpha-reductase ahlose ukungena kwe-hormone ye-BPH futhi akusizi kuphela ukugeleza kwamanzi, kodwa, uma kuthathwa isikhathi eside, empeleni kunganciphisa i-prostate futhi ihlehlise isidingo sokuhlinzwa.
Ukungeza i-Cialis ku-Mix
Ngenxa yezizathu esingase sizijabulele sonke, isikhalazo esikhulu phakathi kwamadoda amaningi athola ukwelashwa nge-alpha blockers, ama-inhibitors ama-5-alpha-reductase noma kokubili ukuthi amaphesenti angu-5 kuya ku-15 we-gents anjengokungcola kokudla nge-erectile, i-libido, noku-ejaculation. Ukulwa nalomphumela omubi ongafuneki, odokotela bama-urologists kanye nodokotela bokunakekelwa okuyinhloko baye baqala ukwengeza ukuxuba imithi ye-Cialis. Ngaphezu kwalokho, ngo-2011, i-FDA yayivele ivume i-Cialis yokwelapha izimpawu ze-BPH, futhi. Ngakho-ke, kumadoda ane-BPH, i-Cialis ibonisa ukusebenza kahle kabili - kuyasiza ngokuchama, futhi kuyasiza ngokungasebenzi kahle kwe-erectile.
Ngenhlanhla, isayensi isekela umkhuba wokwengeza izidakamizwa ngokuyinhloko okuhloswe ngokungafezeki kwe-erectile emiphakathini yemithi ye-BPH. Esivivinyweni esikhulu sokulawulwa okungahleliwe esixhaswe ngu-Eli Lilly, abenzi beCialis (ukuya kubalo), amadoda angama-695 anikezwa i-Cialis noma i-placebo ngaphezu kwe-5-alpha reductase inhibitor i-finasteride.
Imiphumela yabakhuthaza kakhulu ngokuthuthukiswa okuphawulekayo kwesifiso socansi, umsebenzi we-orgasmic, umsebenzi we-erectile kanye nokwaneliseka kocansi jikelele okubonwa kulabo abathatha i-Cialis nge-finasteride. Ngaphezu kwalokho, imiphumela emibi yayincane futhi ibekezeleleka. Imiphumela yalinganiswa emasontweni angu-4, 12 nama-26 e-treatment ngokusebenzisa i-questionnaire ebizwa nge-International Index of Erectile Function.
Njengoba kungalindelwa ezifundweni eziningi usebenzisa izimali ezinkulu ze-Pharma, ukuklanywa kocwaningo kwalolu cwaningo kwakunzima kakhulu. Ngaphandle kwemiphumela ye-placebo, ukulinganiselwa okungenzeka kwalolu cwaningo akubandakanyi ukuqinisekiswa okuqinisekisiwe ukuthi i-International Index of Erectile Function yayiwusizo lapho kulinganisa ukukhubazeka okwenziwe nge-ejaculatory ne-orgasmic kanye nesikhathi esifushane sokwelashwa. Inothi, abacwaningi babheka kuphela i-Cialis co-administration nge-inhibitor engu-5-alpha-reductase, hhayi i-alpha-blocker, futhi.
Imicabango yokuvala
Uma wena noma umuntu omthandayo ehlangabezana nobunzima bobulili eminye emithini yemithi ye-BPH njenge-finasteride futhi engakafiki ku-Cialis, qiniseka ukuthi utshele udokotela wakho oyinhloko noma udokotela we-urologist. Ukwengezwa kwe-Cialis kwindlela yokwelashwa kwakho kuphephile futhi kubekezeleleke futhi kufanele kusize ngokuphila kwakho kocansi kanye nezimpawu ze-BPH ngokwazo.
Encwadini ehlobene, ngenxa yemiphumela yayo ye-hormonal, i-dose ephansi ye-finasteride nayo idayiswa njengo-Propecia, isidakamizwa esinikezwe ukulahlekelwa izinwele. Nakuba abantu abavame ukuthatha i-Propecia bangamadoda amancane anezinkinga ezimbalwa ze-erectile zokungasebenzi, futhi i-Propecia ingumthamo ophansi kune-Proscar, i-Propecia ingaphazamisa nokusebenza ngokocansi. Uma uthatha i-finasteride ukuvimbela ukulahleka kwezinwele futhi uhlangabezana nokuhlukunyezwa kwe-erectile noma izinkinga ze-libidinal, qiniseka ukuthi uyazisa udokotela wakho ochaza.
> Imithombo:
> "Umsebenzi wobulili kumadoda anezibonakaliso ezingaphansi kwe-Urinary Traffic and Prostatic Extension Secondary to Benign Prostatic Hyperplasia: Imiphumela yenyanga engu-6, i-Double-Blind, iSifundo Esilawulwa Ngendawo YaseTadalafil ephethwe yi-Finasteride" ngo-S. > Glina > abalobi abashicilelwe kuyi- Journal of Sexual Medicine (2014).
> Fode M, uSønksen J, McPhee SJ, Ohl DA. Ukuphazamiseka Kwendlela Yokuzala Yomuntu. Ku: UHammer GD, McPhee SJ. ama-eds. I-Pathophysiology of Disease: Isingeniso Semithi Yomtholampilo, I-Seventh Edition . ENew York, NY: McGraw-Hill; 2013. Ifinyelele ngo-1/21/2015.