Umzila weselula we-lymphoid uqukethe lawo maseli egazi aqala emnothweni wethambo ngenqubo ebizwa ngokuthi i-hematopoiesis, futhi ahla ejwayelekile lymphoid stem cell.
Hematopoiesis
Ukukhiqizwa kwazo zonke "amangqamuzana egazi" kuqala emnothweni wethambo ngenqubo ebizwa ngokuthi i-hematopoiesis . Kule nqubo, zonke izinhlobo zamaseli egazi zivela e- hematopoietic stem cell .
Leli cell yangempela, elibizwa nangokuthi i-stpot cell stem cell, lingalinganiswa no-Adamu eBhayibhelini, njenge "ubaba" esivela kuwo wonke amanye amaseli egazi. Lawa maseli abizwa nangokuthi ama-pluripotent avela amangqamuzana, okusho ukuthi anakho amathuba okuba izinhlobo eziningi zamaseli.
Ukuzikhethela kokuqala kwamangqamuzana kwenzeka uma le seli le-pluripotent lilandela enye yezindlela ezimbili zokuthuthukiswa ezibizwa ngokuthi imigqa yeselula. I-pluripotent stem cell ingakwazi ukuhlukanisa phakathi komzila we- myeloid cell noma umugqa weseli lymphoid.
Cell Lymphoid Stem - Lymphoblast
Umzila weselula we-lymphoid uqala nge-lymphoid stem cell, eyaziwa nangokuthi i-lymphoblast noma i-lymphoid progenitor cell. Lena imfoloko emikhulu emgwaqweni njengoba wonke amaseli alesi sigaba aqala ngeseli lymphoid progenitor, kanti wonke amaseli emgqeni we-myeloid (njengama-neutrophils, ama-macrophages, namaseli abomvu egazi) aqala nge-cell proyeloitor cell.
Amaseli Amaseli E-Lymphoid
I-lymphoid progenitor cell (i-lymphoblast) ingahle ihlukaniswe ngokukhethekile nakwezinye izinto ezikhethekile ngaphakathi kwamaseli afaka:
- I-lymphocytes B - i-lymphocytes B noma i- "B cells" isebenza ukuvikela umzimba wakho ezifweni ngokukhiqiza amasosha omzimba.
- I-lymphocytes T - I- t lymphocytes, noma i- "T cells" ngamangqamuzana omzimba omzimba athola, abulale, futhi ahlele impi ngokumelene nodaba lwangaphandle njengama-bacteria, amagciwane, namangqamuzana omdlavuza.
- I-cell killer cell - Amangqamuzana abulalayo asemasimini amangqamuzana omzimba omzimba asebenza ekuqedeni amaseli omdlavuza namaseli anegciwane.
I-Lymphoid Cell Line and Immunity
Amaseli omzimba we-Lymphoid akha cishe ama-15% wamaseli emnothweni onempilo. Amaseli ase-Hematopoietic stem ahlukana ngokuqhubekayo emangqamuzaneni angama-lymphoid progenitor aphinde ahlukanise njalo emangqamuzaneni avuthiwe akha i-lymphoid cell line. Kucatshangwa ukuthi umnkantsha wezintambo uphendukela amangqamuzana egazi amhlophe angu-100 ngehora.
I-Lymphoid Malignancies
Amakhansela afaka amaseli egatsheni lymphoid afaka:
- I-Non-Hodgkin lymphomas - I- Non-Hodgkin lymphomas iqukethe iqembu elihlukahlukene lama -lymphomas angabandakanya ama-B cells noma ama-T cells. Lezi zomshukela zibalwa ngezimbangela eziyi-10 eziphezulu zokufa komdlavuza eziphathelene namadoda nabesifazane.
- I-Hodgkin lymphomas - i- Hodgkin lymphomas nayo i-cancer ejwayelekile, futhi njengamanje umdlavuza ovame ukutholakala kubantu abadala abaseneminyaka engama-15 no-25.
- I-leukemia esebenzayo i-lymphocytic (YONKE) - I-leukemia eqondile ye- lymphocytic ingumdlavuza ohilela i-lymphoblasts - amangqamuzana aqhubeka abe ngamaseli B, ama-T, namangqamuzana ebulalayo. Kuvame kakhulu kubantwana abangaphansi kweminyaka engu-10 kodwa kungenzeka nganoma yisiphi isikhathi.
- I-lymphocytic leukemia (CLL) engapheli - I- Chronic Lymphocytic leukemia ngumdlavuza e-United States ochaphazela kakhulu i-lymphocyte B. I-T cell CLL, ngokuphambene, ivame kakhulu kwezinye izingxenye zaseJapane.
Imithombo:
> Liu, A., Wang, Y., Ding, Y. et al. Ukunquma: Ukukhuliswa kwama-Hematopoietic Stem Cell kanye Nokunyuka kwe-Lymphoid Okujwayelekile Ukudinga Kudinga i-Hematopoietic-I-TLR4 ebizwa ngokuthi i-Hematopoietic, e-Cell-Autonomous TLR4 ku-Model of Endotoxin engapheli. I-Journal of Immunology . 2015. 196 (6): 2524-8.
Sieff, C. Uhlolojikelele lwe-hematopoiesis ne-stem cell function. Kusesikhathini. Kubuyekezwe 05/26/15. http://www.uptodate.com/contents/overview-of-hematopoiesis-and-stem-cell-function
ULiang, H., noJ. Zuniga-Pfcker. I-Hematopoiesis: kusukela ekuqaleni ukuya ekuziphenduleleni kwamandla omzimba. Ucwaningo lwe-Cell Stem Research & Therapy . 2015. I-DOI: 10.1186 / s13287-015-0051-z