Sibutsetelo
Umuntu kuthiwa ube nokubandakanyeka komnyola we-bone noma "i-lymphoma engavumelani" uma izinhlobo ezimbili ze-lymphoma zibonakala kumuntu ofanayo ezindaweni ezimbili ezihlukene emzimbeni.
Ku- non-Hodgkin's lymphoma, noma i-NHL , ukubandakanyeka komnkantsha okungaxhunyiwe okwenzekayo ngokuvamile kwenzeka lapho i-lymphoma enobudlova itholakale ku-lymph node biopsy kodwa i-lymphoma engenamaphutha noma ekhula kancane itholakala emangeni we-bone biopsy.
Umthelela, uma ukhona, we-concordance nokuhlukana kwe-bone lomnumalo ukubandakanya i-lymphoma kubonakala kuncike ezinhlotsheni ze-lymphoma ezitholakele kanye nomongo owengeziwe mayelana nesimo sesifo. Ngokuvamile, ukudweba iziphetho ngokuphathelene nesandulela-sisekelo esekelwe ekubandakanyekeni okunamandla noma okungaqondakali komnkantsha wezinselele kuyinselele ngoba, ezimweni eziningi, ukushicilelwa kwedatha odokotela abathembele kuyo kuncane kakhulu.
Ukubandakanywa kwe-Bone Marrow
Iningi le-B-cell lymphomas elingenayo indolent noma elikhula kancane linomthelela wezintambo ngesikhathi sokuxilongwa. Ngokuphathelene nokusabalalisa i-B-cell lymphoma enkulu (i-DLBCL), okuyinto enobudlova obungenayo i-non-Hodgkin's lymphoma , ucwaningo oluningi lubika ukuthi kuphela ngamaphesenti angu-10 kuya ku-15 amacala okubandakanyeka komnyoba uma kutholakala. Noma kunjalo, ukuhlola umnyo wethambo kubalulekile.
Ukubambisana nokuhlukunyezwa
Lapho ukubandakanywa komnyoba we-bone emzimbeni kungenalo i-Hodgkin's lymphoma, ngokuvamile kuvame ukuthi amangqamuzana omdlavuza emangeni amathanga afana namangqamuzana omdlavuza atholakala kwamanye amasayithi, njengama-lymph nodes - futhi lokhu kwaziwa ngokuthi i- concordance .
Ukuhlukunyezwa kubhekisela kulawo ma-lymphoma lapho i- histology , noma izici nokubukeka kwamangqamuzana omdlavuza, ahluke ngezindlela ezibalulekile phakathi komnkantso wethambo namanye amasayithi okubandakanyeka.
- I-discordant ihluke ku- composite , ebhekisela ezindaweni ezimbili noma ngaphezulu ezihlukile zamaseli e-lymphoma esampula esisodwa se- lymph node.
- Ukuhlukunyezwa kuhluke kakhulu nokuguqulwa , okubhekisela ku-lymphoma eqala ukukhula okuncane noma okungahlonipheki kodwa bese iguqulwa ibe lymphoma enobudlova (ngokuvamile i-DLBCL) ngesikhathi sesifo. Ukuguqulwa kweRichter kuyisibonelo sokuguquka okubandakanya i-lymphocytic leukemia engapheli eguqula ibe yi-DLBCL noma i-Hodgkin lymphoma.
Ukuxilongwa, Ukwelashwa kanye Nomphumela
Ayikho iningi lokuvumelanisa mayelana nokuthi i-lymphomas engavumelani kaningi itholakala kanjani, ukuthi iziphatha kanjani emitholampilo, noma indlela engcono yokuphatha ngayo, ngeshwa. Idatha iningi lisuka kumacala angashadile aye abikwe ezincwadini zesayensi nasezifundweni ezincane ezibukeka emuva ukuze azame ukuthola amaphethini nezinhlangano.
Ukubandakanyeka komnumzana we-concordant kuye kwahlotshaniswa ngokomlando nemiphumela eqhubekayo yokusinda ezigulini ezine-nodal follicular lymphoma. Ukutholwa kubangela ukuthuthukiswa esiteji sika-Ann Arbor se-IV futhi ngaleyo ndlela amaphuzu aphezulu enkampanini esetshenziselwa ukubikezelwa kwe-gage, amaphuzu we-FLIPI.
Ukubandakanyeka komnumzana okungaqondakali komzimba kunjengokungavamile kakhulu phakathi kwama-lymphomas akhula kancane; Ukubandakanyeka kwe-concordant kuye kwacatshangwa ukuthi kwenzeka kumaphesenti angu-40 kuya kwangu-70 weziguli ezine-follicular lymphoma.
Umnkantsha wezintambo ongaxhunyiwe ohilelekile emkhakheni we-lymphoma wamabonakude ubonakala sengathi awuvamile.
Okubalulekile
Ngokusho kwabalobi bendaba ka-2016 eshicilelwe ku "Igazi" - ebizwa ngokuthi 'I-Discordant bone emnothweni ukubandakanyeka ku-non-Hodgkin's lymphoma,' - izifundo eziningi ngezinombolo ezinkulu ziyakwazi ukutshela kangcono ukuthi yikuphi ukuvumelanisa kanye nokuhlukunyezwa izindlela eziningi iziguli ezine-lymphoma.
- Umgogodla we-concordant ohlangene ne-DLBCL ubonakala ubonisa umphumela omubi nakakhulu ukuqhubeka nokuphila okuqhathaniswa namacala ngaphandle kokubandakanyeka komnyo we-bone.
- Umnkantsha ongathandeki obandakanyeka ne-B-cell lymphoma engekho indolent noma ekhula kancane ku-DLBCL esanda kutholakala ayibonakali engathinteki kabi ngokubikezela.
Futhi, nakuba i- FDG-PET iyithuluzi eliwusizo ekuxilongweni kwe-concordant bone emnothweni ekubandakanyekeni ku-DLBCL, cishe kungenzeka ukuzwela kakhulu ekutholeni ukubandakanyeka komnumzana okungaqondakali.
Imithombo
UBrudno J, uTadmor T, uPittaluga S. Umnumzana ongenawo umthambo ongenawo ama-non-Hodgkin lymphoma. Igazi. 2016; 127 (8): 965-70.
UMerli M, Arcaini L, Boveri E, et al. Ukuhlolwa komthelela we-bone lomzimba emitholampilo engeyona i-Hodgkin: Ukuqhathanisa phakathi kwe-histology kanye ne-cytometry yokugeleza. I-Eur J Haematol . 2010; 85 (5): 405-15.
Sehn LH, Scott DW, Chhanabhai M, et al. Impact ye-concordant kanye ne-discordant bone yomnsaba ekubandakanyekeni emphumela ekwenzeni i-B-cell lymphoma enkulu ephathwe nge-R-CHOP. J Clin Oncol . 2011; 29 (11): 1452-7.