Okushiwo Abantu Abahlobo Lwesifo Sikashukela Ngama-Metformin

I-Metformin (amagama okuthiwa ama-Fortamet, i-Glucophage, i-Glumteza, i-Glucophage XR, i-Riomet) yimithi yomlomo esetshenziswa yodwa noma neminye imithi yokwelapha uhlobo lwesifo sikashukela. Kwakuyi-FDA evunyelwe ngo-1994 futhi iyatholakala njengenhlanganisela yemithi i-rosiglitazone / metformin (i-Avandamet).

Ama-Dos no-Dont

I-Metformin isisiza ukwehlisa ushukela wegazi ngezindlela ezintathu:

1. Linciphisa inani le-glucose elibanjwe ekudleni.

1. Ihlisa inani le-glucose elikhiqizwa isibindi.
2. Ukwandisa impendulo yomzimba ku-insulin.

I-Metformin ayinciphisi ngokuqondile ushukela wegazi njengoba i-insulin iyenzayo. Ngakho-ke, akufanelekile iziguli ezine-type 1 yesifo sikashukela esingenayo i-insulin.

Ngubani Okungafanele Awusebenzise?

Abantu abane-type 1 (isifo sikashukela esise-insulin), isifo sezinso noma ukuhluleka kwezinso akufanele balisebenzise. Futhi izingane kufanele zingaphansi kweminyaka engu-10. Abantwana abangaphansi kweminyaka engu-17 akufanele basebenzise ukulungiswa kokukhululwa kwe-metformin.

Isilinganiso

I-Metformin isetshenziswa kabili ngosuku, mhlawumbe ngokudla. Uma umthamo ungaphuthelwa, iphilisi elingabanjwanga kufanele ithathwe ngokushesha ngangokunokwenzeka, ngaphandle uma sekusele isikhathi esilandelayo. "Ukuphikisana" emithini yemithi ukuze wenze umthamo ongabanjwanga akufanele kwenziwe.

Imiphumela emibi kanye nezingozi

I-Metformin ngokuvamile ibangela ukuhuda uma kuthathwa ngaphandle kokudla. Ezinye imiphumela emibi zihlanganisa ukucasula kwesisu, igesi nokuqhaqhazela, ukunambitheka kwe-metallic, ukukhanda ikhanda, ukukhwehlela nokuhlunguphazeka kwamasipha.

Uma i-metformin ingenele ukulawulwa ushukela egazini, iziguli ezithatha i-metformin nazo zingathola ushukela ophezulu wegazi , ezinezimpawu zokudideka, ukuwayeka, umlomo omile, ukuhlanza, umoya ophunga omnandi, noma ukulahlekelwa ukwazi. Noma ubani ohlangabezana nanoma iyiphi yalezi zimpawu-noma ubuhlungu besifuba, ukuqhuma, noma ezinye izimpawu ezibuhlungu-kudingeka afune ukunakekelwa ngokushesha.

Ngokuvamile, i-metformin ingabangela i-lactic acidosis, isimo esibucayi esibonakala nge-lactic acid egazini. I-Lactic acidosis, uma ingaphathwa kabi, ingaholela ekuhlulekeni komzimba ngisho nokuboshwa komzimba. Izimpawu zihlanganisa ukukhathala, ubuthakathaka, ubuhlungu besisu, ukuphefumula nokuphefumula.

Nakuba kungavamile uma kungekho ezinye izinkinga zezokwelapha, izidakamizwa ezidakamizwa noma ukusebenzisana kwezidakamizwa, i-metformin ingabangela ushukela wegazi ophansi (u-hypoglycemia), obhekene nokuzondeka, ukuthuthumela, ukujuluka, ukudideka, noma ukuphazamiseka emlonyeni.

Ukusetshenziswa kwe-'E-Label '

I-Metformin ingahle isetshenziswe ngaphandle kwelebuli ukuze kusize ngokulahlekelwa isisindo, i-polycystic syndrome ye-ovary, isifo sikashukela sokubeletha nesifo se-HIV lipodystrophy.

Amathiphu nokuqapha

Abantu abanesifo sikashukela kufanele balandele izinhlelo zokudla nokuzivocavoca okunempilo njengoba kunconywa abahlinzeki babo bezempilo. Ukudla akufanele kungeneke futhi ukuphuza utshwala kufanele kugwenywe.

Imishanguzo emisha kanye nemithi engaphezu kwe-counter kumele ingathathwa ngaphandle kokuvunywa kochwepheshe bezempilo. Ngaphezu kwalokho, abantu abanesifo sikashukela kufanele babe nokuhlola okujwayelekile ukuhlola isifo sikashukela sabo, kuhlanganise nokuhlolwa kwegazi ukuhlola isimo sabo soshukela egazini eside (HbA1c).

I-Metformin kufanele ishiywe amahora angu-48 ngaphambi kwanoma iyiphi inqubo yamazinyo noma yokuhlinzwa nangaphambi kokuthola umehluko ohlukile (ie nge-CT scans). Kubalulekile ukuthi abantu be-metformin batshele abahlinzeki babo bezempilo ukuthi bayithatha.

_Imithombo:

_{"I-Metformin: Ukwaziswa kwezidakamizwa." Phezulu kwi-Inthanethi. 2007. UpToDate.}

_{"I-Metformin: Ulwazi lwezidakamizwa zeziguli." UpToDate Online. 2007. UpToDate.}

_{"I-GlaxoSmithKline iveza ukugunyazwa kwe-FDA nokuqaliswa kwe-Avandamet® (i-rosiglitazone i-maleate ne-metformin HCl) njenge-Treatment Initial ku-Treatment of Type 2 Diabetes." GlaxoSmithKline. 11 Jul 2006. GlaxoSmithKline.}

_{"I-Metformin." Imininingwane yeDrugline Plus. 1 Meyi 2007. I-US National Library of Medicine.}