Ama-Biguanides ahlukanisa imithi yesifo sikashukela yomlomo esetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo lwesibili, lapho i-metformin iwuphawu lomkhiqizo. Lezi zidakamizwa zisebenza ngokuthinta ukukhiqizwa kwe-glucose evela ekugayeni. Ayibangeli u-hypoglycemia ngisho nokusiza ngokulahlekelwa isisindo kanye nezinombolo eziphansi ze- cholesterol . Ziyizidakamizwa ezivame kakhulu ezinqunyiwe zesifo sikashukela sohlobo lwe-2.
- Futhi eyaziwa njenge: Metformin, i-Glucophage
- Ama-Biguanides: Eziyisisekelo zale mithi
- I-Metformin : Funda kabanzi mayelana nokuthi lesi sidakamizwa sisetshenziswa kanjani.
Imithi ye-Biguanide yesifo sikashukela
I-Metformin yi-biguanide okwamanje emakethe yokuphathwa ngoshukela. I-glucophage (metformin) ne-Glucophage XR (i-metformin ekhulisiwe-ukukhululwa) yizona ezaziwa kakhulu kulezi zidakamizwa. Amanye amagama abhalisiwe afaka i-Fortamet, i-Glumetza ne-Riomet. Ibuye itholakale nemikhiqizo ehlangene nezinye izidakamizwa zesifo sikashukela.
Ama-Biguanides aqale atholakala e-lilac yesiFulentshi, ebizwa nangokuthi i-rue yezimbuzi, iGalega officinalis. Ukucwaninga ngemiphumela yaso ekunciphiseni amazinga wegazi glucose kuholele ekuthuthukiseni izidakamizwa ezincane ezinobuthi. Ezinye izindlela zokwelapha zingase zifake lesi sitshalo, kodwa uma usebenzisa imithi yesifo sikashukela kufanele uqaphele ngenxa yokuxhumana.
Ezinye izinhlobo ze-biguanides zakhiwe kepha zihoxiswa emakethe. Lokhu kuhlanganisa phenformin, eyaqala ngo-1957 ngesikhathi esifanayo ne-metformin kodwa yahoxiswa ngasekupheleni kwawo-1970 ngoba yayihlobene nengozi enkulu ye-lactic acidosis.
Lokhu kwaba, ngeshwa, ebulalayo engxenyeni yamacala.
I-Buformin yasungulwa eJalimane ngo-1957 kodwa yayingakaze ithengiswe e-United States. Kwatholakala nokuthi kunengozi eyengeziwe ye-lactic acidosis. Isusiwe emakethe emazweni amaningi kepha isatholakala kwezinye.
Ngaphezu kokusetshenziswa kwayo kwesifo sikashukela, ezinye izinhlobo ze-biguanides zisetshenziswa njengezidakamizwa ze-antimalarial, proguanil, ne-chlorproguanil.
Ama-Biguanides Asebenza Kanjani Ne-Diabetes?
I-Metformin isebenza ukulawula inani leshukela egazini lakho. Akuthinti inani le-insulin oyikhiqizayo, kodwa landisa ukuzwela kwi- insulin . Lokhu kusiza amangqamuzana akho athathe i-glucose ekusebenziseni kwayo amandla, anciphisa ukukhiqizwa kwe-glucose esibindi, futhi anciphisa ukuhlunga kwe-glucose egazini lakho legazi. Ukusetshenziswa kwe- glucose emathunjini kuveza i-lactic acid, esetshenziselwa isibindi kodwa ingabangela umphumela ohlangothini lwe-lactic acidosis. I-Metformin ayibangeli i-hypoglycemia yomtholampilo, okuyinto enhle ngaphezu kwamanye imithi yesifo sikashukela. Futhi akubangeli ukuzuza kwesisindo futhi kunemiphumela emihle yokunciphisa ezinye izinkinga zempilo yengqondo.
I-Metformin ivamiselelwe ukuba i- type 2 yesifo sikashukela uma lesi sifo singakwazi ukulawulwa izinguquko zendlela yokuphila yodwa. Kuyinto imithi ngomlomo, ngakho kungathathwa njengendlela tablet noma liquid. Kuye ngesimo, kuthathwa kathathu kathathu nsuku zonke. Kukhona amafomu okukhululwa okunwetshiwe kanye namafomu adinga ukuthathwa ngokudla. Imiyalelo kumele ilandelwe ukusetshenziswa okuphephile komkhiqizo ngamunye.
Njengoba isifo sikashukela siqhubeka, ama-insulin injection angadingeka ukulawula ushukela wegazi kanye ne-metformin ingasetshenziswa ukuthuthukisa ikhono lomzimba lokusebenzisa i-insulin.
> Imithombo:
> Bailey CJ, "Biguanides kanye ne-NIDDM," Ukunakekelwa kwesifo sikashukela, ngo-1992 Juni, 15 (6) 755-72.
> I-Metformin, i-MedlinePlus, i-US National Library of Medicine, 2/15/2015
> Krentz AJ, Bailey CJ. "Ama-antialabetic agents omlomo: indima yamanje kuhlobo lwesibili lwesifo sikashukela." Izidakamizwa. 2005; 65 (3): 385-411.