Akukho Ukwelashwa Kodwa, Kodwa Ukudla Kwe-Western Kungase Kungabikho Triterpenes
I-Lupeol, eyaziwa nangokuthi i-fagarsterol, iyinkimbinkimbi yemvelo etholakala ezitshalweni ezithile emvula yamanzi ashisayo, kanye nokudla okuthile. I-Lupeol inesithakazelo esikhulu ososayensi abacwaninga izidakamizwa zemvelo ezinezinto ezingase zibe zindlela zokwelapha. Ucwaningo lukhawulelwe ekufundeni kwe-vitro nesilwane, ngakho-ke kusencane kakhulu esigabeni sokutholakala, kodwa uLupeol kubonakala sengathi unezindawo zokulwa nokuvuvukala nokulwa nomdlavuza kwezinye zezifundo.
Kuyini Lupeol?
I-Lupeol ingeqembu lezinhlanganisela ezibizwa nge-triterpenes. I-Triterpenes yizingxenye ezibalulekile zezitho zomzimba zesitshalo. Lezi zinhlanganisela zenza okufanayo ne-cholesterol ezinqenqemeni zesilwane sezilwane-okungukuthi, ziza ukugcina ama-bilayers emithini yezinhlamvu zezitshalo ezinzile. I-Triterpenes empeleni ibe yinkinga yezifundo ezingu-25 ezihlukene zokwelashwa futhi zinezithakazelo ezakhiweni zazo zokunciphisa i-cholesterol .
Emazweni aseNtshonalanga, kulinganiselwa ukuthi sidla cishe 250 mg ngosuku lwe-triterpenes, ikakhulukazi etholakala emafutheni omifino, okusanhlamvu, izithelo nemifino. Ukutholakala kwama-triterpenes kungase kube kakhulu emazweni aseMedithera nasemizini enezici zokudla ezicebile ngamafutha omnqumo.
I-Lupeol iyinhlangano ye-triterpene enomsebenzi obaluleke kakhulu we-biologic. Izifundo ezinikeza ulwazi mayelana nomsebenzi we-biologic we-Lupeol ziphakamisa ukuthi yileli kheli elibhekene nalokho. Kucatshangwa ukuthi izindlela eziyinhloko zamangqamuzana ezihilelekile ekuvuvukala nomdlavuza zihilelekile.
Yiziphi Imithombo YaseLupeol?
I-Zanthoxylum iyinhlobo yezinhlobo ezingaba ngu-250 zezihlahla nezitshalo emndenini wase-citrus, ohlala ezindaweni ezifudumalayo nezifudumele emhlabeni jikelele. Ezinye zezinhlobo zinezinhlanzi eziphuzi, futhi izithelo zezinhlobo eziningana zisetshenziselwa ukwenza i-spice, i-pepper ye-Sichuan. Amalungu we-genus nawo ngezinye izikhathi asetshenziswa njengezihlahla ze-bonsai.
Amagxolo asetshenzisiwe emithi yokwelapha yamazinyo, i-colic, ne-rheumatism. Imithombo emihle yeLupeol kule nhlobo ihlanganisa iZanthoxylum riedelianum, omunye wemithi ende kunazo zonke e-Amazon ephansi yasePeru. Ngokuthakazelisayo, iLupeol itholakala nesitshalo esivela ePhilippines, uFicus pseudopalma, esetshenziselwa imithi yokwelapha yezinso zamatshe nesifo sikashukela. Izitshalo ezahlukene ezahlukahlukene manje seziyaziwa ukuthi ziyimithombo emihle yaseLupeol, kanti uLupeol itholakale ngisho nemifino efana neklabishi omhlophe, pepper, ikhukhamba, utamatisi; kanye nezithelo ezifana nomnqumo, umkhiwane, imango, sitrobheli, namagilebhisi abomvu.
Ingabe i-Rainforest Compound izosiza ukwelapha nokuvimbela umdlavuza?
Ucwaningo luye lwabonisa ukuthi ukudla okucebile kuma-phytochemicals (okuwukuthi yiLupeol yedwa kuphela) kunganciphisa kakhulu ingozi yezincane zamanyevuza ezivamile ngamaphesenti angu-20.
Kungakhathaliseki ukuthi iLupeol izoba usizo ekwelapheni umdlavuza ihlala ibonakala, kepha ukufundwa okuvela ku-vitro nesifundo sezilwane okwenziwe kuze kube manje kuye kwaba mnandi. Mhlawumbe njengoba kukhuthazwa ukuthi iLupeol, emithonjeni yayo yokwelashwa ephumelelayo, kubonakala ingabonakali ubuthi obukhulu emangqamuzaneni ajwayelekile kanye nezicubu ezifundwayo. Lokho kusho ukuthi ukuphepha nokubhekela akuzange kuhlolwe ekuvivinyweni komtholampilo, kanti imiphumela ingase ihluke ezifundweni ze-vitro nesilwane.
Uhlelo lweSikole Sezokwelapha kanye neMpilo Yomphakathi, iYunivesithi yaseWisconsin-Madison isihlolisise imiphumela emihle yeLupeol ngezinhlobo ezahlukene zomdlavuza ezifana ne-prostate, isikhumba, umdlavuza we-pancreatic kanye nesifuba. Ngokususelwa ekufundeni okubandakanya ukwelashwa kwamangqamuzana omdlavuza kusuka emigqeni ehlukahlukene yamaseli, leli qembu likholwa ukuthi uLupeol unamandla okusebenza ezindleleni eziningi zamangqamuzana.
Kuthiwani Ngezikhwama Zegazi?
Ukufunda noLupeol kuyisiqalo, kanti uphenyo olwengeziwe luyadingeka ukukhanyisa lo mbuzo. Phakathi naleso sikhathi, ukufundwa kwezifundo eziningana zangaphambili kudinga ukuqhubekisa umsebenzi oqhubekayo.
Ucwaningo oluqhutshwa yi-Aratanechemuge nabalingani bakhe lubonisa ukuthi iLupeol iveza i-apoptosis (i-cellmed death cell) yama-human promyelocytic HL-60 cells of leukemia.
Lolu cwaningo lubonise ukuthi iLupeol yenza inguquko ku-cell nuclei nokuhlukaniswa kwe-DNA (isici se-apoptosis) ngendlela ehambisana nomthamo we-Lupeol onikeziwe.
Enye iqembu labacwaningi, i-Cmoch kanye nozakwethu, yabonisa ukuthi i-Lupeol inxusa ukufa kweselula ezinhlobonhlobo ezahlukene zomdlavuza we-cancer, kuhlanganise ne-T-lymphoblastic leukemia, ne-myeloma eminingi.
> Imithombo:
> Moreau RA, Whitaker BD, Hicks KB. Ama-Phytosterols, i-Phytostanols, nama-Conjugates abo ekudleni: Ukuhlukahluka kwesakhiwo, ukulinganisa okulinganiselwe, nokusetshenziswa kwezempilo. I-Prog Lipid Res. 2002; 41: 457-500.
> Santiago LA, iMeya ABR. I-Lupeol: I-Triterpene E-antioxidant ku-Ficus Pseudopalma Blanco (i-Moraceae). I-Asian Pac J I-Trop Biomed. 2014; 4 (2): 109-118.
> Saleem M. Lupeol, i-Novel Anti-Inflammatory and Anti-Cancer Dietary Triterpene. I-Cancer Vumela . 2009; 285 (2): 109-115.