Isayensi ngemuva kwenzuzo yalesi sengezo sokudla ayisakhulumi
I-osteoarthritis (OA) yinto evamile, ekhubaza izifo zamalunga, okubangela izimpawu zobuhlungu, ukuqina, nokuvuvukala, ikakhulukazi emadolweni, emlonyeni, emgodleni, nasezinhlangeni zomzimba.
Indlela i-OA eqala ngayo impela iyinkimbinkimbi kodwa ekugcineni ihilela ukubhujiswa kwezicubu ezivikela amathambo ekugubheni ndawonye (lezicubu zibizwa ngokuthi i-articular cartilage ).
Lokhu ukubhujiswa kwezicubu kubangela ukukhula kwethambo, okuyinto ngeshwa kudala i-bone spurs kanye namajoyina angasebenzi, okwenza kube nzima ukusebenzisana kokuhlanganyela.
Ngenxa yezibonakaliso, ikakhulukazi ubuhlungu, obangela i-osteoarthritis, abantu abane-OA bafuna izindlela zokwelapha ezinganciphisa ubuhlungu babo. Izithako zokudla ziye zanda kakhulu, ikakhulu kulabo abangakwazi ukuthatha imithi yokwelapha i-OA-easing njenge-antisteroidal anti-inflammatories (ama-NSAID).
Okunye ukwesekwa kokudla abanye abantu abasebenzisa ukuphatha i-OA yabo kubizwa nge-SAM-e (S-adenosylmethionine).
Ukuqonda i-SAM-e
Ungase umangale uma ufunda ukuthi i-SAM-e iyatholakala ngokwemvelo kumaseli omuntu. Yenziwe kumamino acid okuthiwa i-methionine futhi idlala indima ekulawuleni izinqubo ezithile zezinto eziphilayo ezinamaseli afana nokulondoloza izingqamuzana zamangqamuzana, ukususa izinto ezinobuthi emzimbeni, nokukhiqiza amakhemikhali akhuthaza imizwelo.
Ngokuthakazelisayo, i-SAM-e yaqala ukufundelwa indima yayo ekucindezelekeni. Esifundweni sokucindezeleka, abanye babahlanganyeli abane-OA baphawule ukuthuthukiswa kwesibonakaliso sokuhlanganyela ngemva kokuthatha i-SAM-e. Lokhu kwasungula ngokucophelela indima ye-SAM-e njengendlela yokukhulula ubuhlungu kulabo abane-osteoarthritis.
Ngeshwa, imiphumela yezifundo ku-SAM-e azinikeze ubufakazi obuqinile bokusebenza kwayo.
Eqinisweni, ucwaningo luye lwabonisa ukuthi uma kuqhathaniswa ne-placebo, i-SAM-e ifana nokunciphisa izimpawu zobuhlungu obuhlobene ne-OA kanye nomsebenzi womzimba.
Uma kuqhathaniswa nama-NSAID, ucwaningo lubonisa ukuthi labo abathatha i-SAM-e babenesihluthulelo esifanayo nokuthuthukiswa komsebenzi ohlangene, nakuba imiphumela emibi yayingaphansi kweqembu le-SAM-e.
Okokugcina, ekufundeni okudala, okuncane okuqhathaniswa nama-1200mg ngosuku lwe-SAM-E nge-200mg ngosuku lweCelebrex ngamasonto angu-16 (nge-knee osteoarthritis), i-Celebrex yabonisa ukunciphisa ubuhlungu obukhulu kakhulu kune-SAM-e ngenyanga yokuqala. Kodwa-ke, kwakungekho umehluko omkhulu phakathi kwe-SAM-e ne-Celebrex ngenyanga yesibili.
Abacwaningi abavela kulolu cwaningo baphetha ngokuthi i-SAM-e yayithambekele kancane, kepha ngokuhamba kwesikhathi kwaphumelela njengeCelebrex ngokuphathwa kwe-knee osteoarthritis.
Imiphumela engaba yingozi ye-SAM-e
Njengemithi eminingi noma izithako ezengeziwe, i-SAM-e ingabangela ezinye izibonakaliso ezimbi, nakuba lezi zingavamile, futhi ngokuvamile zibonwa ngamazinga aphezulu. Le miphumela emibi ingafaka:
- I-nausea
- Flatulence
- Uhudo
- Ukuvota
- Izinwele
Ngaphezu kwalokho, i-SAM-e ingase ihlanganyele nezithako ezithile noma imishanguzo yokudla, njenge-anti-depressants, i-L-tryptophan, noma i-St John's Wort. Yingakho kubaluleke kakhulu ukutshela udokotela wakho yonke imithi oyithathayo, kuhlanganise nanoma imiphi imithi engaphezu kwe-counter.
Ochwepheshe nabo batusa ukugwema i-SAM-e uma une-bipolar disorder noma isifo sika-Parkinson. Futhi, ukuphepha kwe-SAM-e akuzange kuhlolwe ekukhulelwe noma ekunceliseni, ngakho kufanele kugwenywe. Okokugcina, kukhona ukukhathazeka ukuthi ukuthatha i-SAM-e kungabangela ukutheleleka okukhulu kwamaphaphu (okuthiwa i-Pneumocystis pneumonia noma i-PCP) kubantu abanesisindo somzimba esibuthakathaka, njengabantu abane-HIV.
Izwi elivela
Uma une-osteoarthritis, kubalulekile ukuxoxa ngesiphakamiso sokwelashwa nodokotela wakho. Okwamanje, akunakwenzeka ukuthi i-SAM-e izoba yingxenye yalolu hlelo ngokusekelwe ebufakazini obungenakulinganiswa nokulinganiselwe ukusekela inzuzo yayo.
Ngethemba ukuthi ngokuhamba kwesikhathi, kuzoba nezinfundo ezinkulu, okungahleliwe ukuze kunqume kangcono indima ye-SAM-e ekwelapheni kwe-OA.
Noma kunjalo, ungadangali, ngoba kunezinhlobo eziningi zokwelashwa ezingasiza ekunciphiseni ubuhlungu bakho be-OA futhi uthuthukise umsebenzi wakho ohlangene njengokulahlekelwa kwesisindo (uma ukhuluphele kakhulu noma ukhuluphele), ukuvivinya umzimba, kanye nokwelashwa ngokomzimba.
Imithi isetshenziselwe izimpawu ezinzima, ngoba ayishintshi inkinga yesifo. Imithi ejwayelekile yokwelapha i-OA ihlanganisa:
- Ama-NSAID (kokubili ngomlomo nangesikhumba)
- I-Capsaicin
- I-Cymbalta (i-duloxetine)
- I-Corticosteroids injected in the space joint affected
> Imithombo:
> De Silva V et al. Ubufakazi bokusebenza kwemithi ehambisanayo neminye ekulawuleni i-osteoarthritis: ukubuyekezwa okuhlelekile. I-Rheumatology (i-Oxford). 2011 Meyi; 50 (5): 911-20.
> McAlindon > TE et al. Imihlahlandlela ye-OAR for the non-surgical management of knee osteoarthritis. I-osteoarthritis . 2014 Mar; 22 (3): 363-88.
> Isikhungo Sikazwelonke seMpilo Ephelele kanye Nezohlanganiswa. (2017). I-S-Adenosyl-L-Methionine (SAMe): Ekujuleni.
> Rutjes AWS, Nüesch E, Reichenbach S, Jüni P. S-Adenosylmethionine ye-osteoarthritis yamadolo noma i-hip. Database Cochrane Yokuhlolwa Okuhlelekile 2009, Issue 4. Art. Cha: CD007321.
> SAM-e. (nd). I-Arthritis Foundation.