I-Hyaluronan Injections ye-Knee Osteoarthritis

by UCarol Uustice

10 Izinto Okufanele Uzazi NgeHyaluronan

Ama-injection ye-Hyaluronan yindlela yokwelapha ye- osteoarthritis yamadolo . I-osteoarthritis yisifo esivumelanayo esiyingozi esithinta ngokuyinhloko i-cartilage. Ukuphela kwamathambo amabili okuhlangene okujwayelekile kuhlanganiswe ne-cartilage, okuvumela amathambo ukuba agxilane. I-cartilage iphinde isebenziseke kakhulu.

Esikhathini se- osteoarthritis , njengoba uqwanga luhamba, ama- synovial fluid shintsha futhi alahlekelwa amandla ayo okugcoba ukujoyina.

Ubuhlungu, ukuqina, nokulinganisa okulinganiselwe kokunyakaza kokuhlangene okuthintekile kungumphumela wokuwohloka. Ukwelapha okulimaza i-hyaluronan emadolweni, okubizwa ngokuthi i-viscosupplementation, kuwumzamo wokuthuthukisa ukugcoba kwamadolo, ukunciphisa ubuhlungu, nokuthuthukisa ukuhamba okuningi. Nakhu izinto eziyishumi okufanele wazi mayelana nemigomo ye-hyaluronan.

1 - Kukhona okwamanje ama-hyaluronates amahlanu avunywe yi-US Food and Drug Administration.

Izijoka ze-Hyaluronan zibhekwa njengezokwelapha noma zokwelashwa kunokuba izidakamizwa. I-Viscosupplementation ye-osteoarthritis iye yafundiswa kusukela ngawo-1970. Ngo-1997, ama-hyaluronate amabili aqala ukuvunyelwa yi-FDA kanti abanye abathathu bebelokhu bevunyelwe i-FDA. Uhlu lwama-injection ye-hyaluronan olulandelayo luhambisana nezinsuku zabo zokugunyazwa:

Hyalgan - May 28, 1997
I-Synvisc - Agasti 8, 1997
I-Supartz - January 24, 2001
I-Orthovisc - ngo-5 kuFebhuwari 2004
Euflexxa - Disemba 3, 2004

I-Synvisc-One - February 26, 2009

2 - I-Hyaluronan ngokuvamile ayiyona ukwelashwa komugqa wokuqala we-knee osteoarthritis.

Ngokuvamile, izilonda ze-hyaluronan (futhi ngezinye izikhathi zibizwa ngokuthi i-viscosupplements) zinconywa iziguli ezingazange zithole ukuphumula okwanele kokuphumula okukhethwa kukho ukwelapha okungavamile:

Imithi

Ukuzivocavoca / Ukwelapha umzimba
Ukulahlekelwa isisindo uma isiguli singaphezu komzimba
Ukushisa nokubandayo
Amadivaysi okuhamba ngokusiza (isib., Umoba)

Nakuba imijovo ye-hyaluronan ingavunyelwe ngokuvamile ngaphambi kokuzama ezinye izinketho zokwelashwa , imiphumela enhle ngokuvamile iyenzeka uma isiguli sisesimweni sokuqala se-osteoarthritis. Iziguli ezisezingeni elilandelayo le-osteoarthritis, okungenzeka ukuthi zilindele ukuhlinzwa ngokuguqula amadolo , zibhekwa njengezilungelo zokugaya izilonda ze-hyaluronan ngakho-ke banethemba lokuthi bangathola usizo ngenkathi belinde.

3 - Inkambo yokwelashwa yezinhlobo ezinhlanu zejova ye-hyaluronan iyahlukahluka.

Ukwelashwa okuphelele nge-Synvisc, Orthovisc , noma i-Euflexxa kudinga ama-injection amathathu emadolo ahlukene awanikezwa ngesonto elilodwa. Bobabili uHyalgan noSupartz badinga injection ehlukene emihlanu banikwe isonto elilodwa ngaphandle. Izijovo zinikezwa udokotela noma odokotela bamazinyo ehhovisi labo. Amadolo owodwa noma kokubili angajozwa ngesikhathi esifanayo. Ukwengezwa kwe-Synvisc-One kuya ku-2009 ngo-2009 kwenza izijovo zilula kakhulu, ezidinga injini eyodwa kunezingxube eziningi.

4 - Ukuphikisana kwama-hyaluronan kahle kuye kwaxoxwa kanjani.

Ucwaningo lwezokwelapha luye lwaphetha ngokuthi izilonda ze-hyaluronan zinganciphisa ubuhlungu futhi zithuthukise ukusebenza ezigulini ezine-osteoarthritis emincane.

Ngenkathi abanye abagxekayo bebhekene naleso siphetho futhi basikisela ukuthi izifundo zaphutha ngandlela-thile, abanye odokotela bakholelwa ukuthi ayikho impendulo ecacile ukuthi ngabe ama-hyaluronan injection asebenza kangcono kunezijovo ze-corticosteroid noma imithi yomlomo . Akukho bufakazi obukhombisa ukuthi izilonda ze-hyaluronan zithinta inkambo yesifo esiyisisekelo. Kusobala ukuthi ukujola akuyona ikhambi.

5 - Phakathi kweziguli ezasizwa yi-hyaluronan injection, lapho ukuphumula ubuhlungu kwenzeka khona.

Ukuphumula okubaluleke kunabo bonke okwenzeka emasontweni angu-8 kuya kwangu-12 emva kokujola kokuqala kweziguli eziningi. Ucwaningo luye lwabonisa ukuthi i-Synvisc ne-Hyalgan inikeza ukuphumula kobuhlungu e-knee osteoarthritis izinyanga eziyisithupha, kanti ezinye iziguli zithola ukuphumula isikhathi eside.

I-Supartz iboniswe ezifundweni ukuhlinzeka ukukhululeka kobuhlungu kuze kube yizinyanga ezingu-4 1/2 ngemuva kokujola kwesihlanu.

Iziguli zingase zikwazi ukuphinda inkambo yokwelashwa nge-injection ye-hyaluronan. Isibonelo, isiguli esinezinyanga eziyisithupha zokuphumula okuvela ku-Synvisc kodwa seyibuyile ubuhlungu singase sibe yi-candidate yenye inkambo ye-Synvisc injection.

6 - Ukunciphisa imiphumela emibi engaba khona, ngemuva kokugaya iziguli kufanele zigweme imisebenzi eqinile kwamahora angu-48.

Imiphumela emibi kakhulu ehambisana nomjovo wokujova, ovame ukuba mnene, faka:

ukulimala kwesikhashana somjovo wesayithi
ukuvuvukala
ubomvu nokufudumala
itching
ukulimaza

7 - Izijovo ze-Hyaluronan zivunyelwe i-FDA kuphela ye-osteoarthritis yamadolo.

Ngolunye usuku, i-viscosupplementation ingasetshenziselwa ukuphatha amanye amalunga aphethwe yi-osteoarthritis. Izijovo ze-Hyaluronan ze-shoulder, u-hip, ne-ankle zifundiswa.

8 - Isiguli akudingeki siyeke ezinye izidakamizwa ezithathayo lapho zithola izilonda ze-hyaluronan.

Akufanele kube khona ukuxhumana okungahambi neminye imithi yobuhlungu noma imithi elwa nokuvuvukala okwenziwa isiguli.

9 - Bobabili i-Medicare kanye nomshuwalense wangasese bavuselela izindleko zemishini yezokwelapha nezinqubo ezithathwa njengokwenyama.

Njengamanje, i-Medicare izokhipha izilonda ze-hyaluronan ngamadolo kuphela. I-Medicare idinga nobufakazi be-x-ray we-knee osteoarthritis. I-Medicare izokhipha kuphela izilonda ze-hyaluronan uma inganikezwa ngokushesha kungaphezu kwezinyanga eziyisithupha. Umshuwalense wangasese ungaba nemithetho ehlukene ngakho ngaso sonke isikhathi kuhle ukuhlola. Hlola njalo izibuyekezo ze-Medicare futhi.

10 - Kunezici ezibalulekile zokuphepha okufanele uzicabangele ngaphambi kokusebenzisa izijovo ze-hyaluronan.

Iziguli ezinqwenela ukuzama i-Synvisc, eziphikisana nemikhiqizo yezinyoni (ie, izimpaphe, amaqanda noma izinkukhu), kufanele zikhulume nodokotela wazo. Iziguli kufanele zenze udokotela wabo azi imilenze evuvukale noma igciwane. Futhi, izilonda ze-hyaluronan azihlolwanga ezinganeni, abesifazane abakhulelwe, noma omama abahlengikazi.

_Imithombo:

_{Kuyini i-Viscosupplementation?} _{Umtholampilo waseCleveland.} _7/28/2007. _{http://www.clevelandclinic.org/health/health-info/docs/3300/3363.asp?index=11428}

_{Incomo ye-Medical Management ye-Osteoarthritis ye-Hip ne-Knee.} _{I-American College of Rheumatology.} _7/26/2007. _{http://www.rheumatology.org/publications/guidelines/oa-mgmt.asp?aud=mem}