Izenzakalo ezimbi ezihlanganiswa nama-NSAID omlomo we-Topical noma omlomo angakusiza Uzinqume
Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) ziphakathi kwemithi ethandwa kakhulu futhi ejwayelekile kakhulu ye-arthritis. Ama-NSAID angathathwa ngomlomo ngesimo samathebulethi, ama-capsules noma uketshezi. Ama-NSAID atholakalayo nokubunjwa kwezinto eziphezulu, njenge-ukhilimu, i-gel noma i-liquid esetshenziswa esikhumbeni.
Ama-NSAID e-Topical Work asebenza kanjani?
Ama-NSAID e-Topical, njenge-ibuprofen ye-topical noma i- Voltaren gel , asetshenziselwa isikhumba ngaphezu kokujoyina okubuhlungu.
Kunezinzuzo ezithile ezihlanganiswe nama-NSAID angokwezihloko ezihlanganisa:
- ukulethwa kwezidakamizwa ezithuthukisiwe kwezicubu ezithintekile
- ukwehla kwesimiso semiphumela emibi njenge-peptic ulcer nesisu sokuphuma kwamathumbu
Ama-NSAID e-Topical angene kancane kancane, ehambisa amanani amancane ohlelweni lokujikeleza kwesistimu. Uma kuqhathaniswa nama-NSAID omlomo, uhlelo lokusebenza lwe-topical luholela ezingxenyeni eziphakeme eziphezulu ze-NSAID ku-dermis (ungqimba wesikhumba ngaphansi kwe-epidermis equkethe izicubu ezixhunyiwe). Izingqinamba ezitholakalayo ezicubu ze-muscle ngezansi indawo yesicelo ziyahlukahluka, kodwa okungenani zilingana nalokho okufeziwe ngokuphathwa ngomlomo kwama-NSAID.
Ama-NSAID angama-Topical afinyelela emzimbeni wamanzi , kodwa ngabe yikuphi indlela futhi okuyiyona ndlela engakaze yenziwe. Ukungqubuzana komuntu ngamunye esikhumbeni kungabika ukuhlukahluka okuthile okubonwa ekuthatheni ama-NSAID e-topical.
Ngokuvamile, kunzima ukunquma ukuthi ama-NSAID angokwezihloko noma ezomlomo angcono yini ngoba kuboniswe ukuthi ekuvivinyweni komtholampilo kukhona izinga eliphezulu le-placebo eliphakeme kakhulu.
Abantu babika ukukhululeka kobuhlungu ngisho noma kungekho isithako esisebenzayo epilisi noma ukhilimu.
Ama-NSAID Oral esebenza kanjani?
Ama-NSAID omlomo ngamaphilisi, ama-capsules noma imithi yoketshezi egonywe. Badlula ohlelweni lokugaya futhi bagxila emgodleni wegazi, benomphumela kuwo wonke umzimba. Ama-NSAID omlomo asebenza ngokuvimbela i- cyclooxygenase (COX) , i-enzyme eyenza i-arachidonic acid ibe yi-prostaglandin ne-leukotrienes.
I-Arachidonic acid ikhishwa emlonyeni we-phospholipids ekuphenduleni isenzo sokuvuvukala. I-Prostaglandin isungula impendulo yokuvuvukala. Ama-NSAID aphazamisa ukukhiqizwa kwe-prostaglandins ngokuvimbela i-cyclooxygenase.
Ukungqubuzana Kwezehlakalo Ezimbi Phakathi Kwezingxoxo Zomlomo Nezihloko ze-NSAID
Ama-NSAID e-Topical aphethe iphrofayli yokuphepha engcono kune-NSAID yomlomo. Ukusebenza okubi kakhulu okusetshenziselwa ukusetshenziswa kwe-NSAID kwezobuciko kwenzeka cishe ezigulini ezingaba ngu-10 kuya kwezingu-15% futhi ngokuyinhloko kuhlanganiswa (ukukhwabanisa ne-pruritus - ukubukeka - lapho kusetshenziswe khona i-NSAID yezobuchwepheshe). Ukuthinta izidakamizwa ezimbi emithonjeni yezinyosi akuvamile nge-NSAID yama-topical, uma kuqhathaniswa nezigameko ezingu-15% ezibikwe ama-NSAID omlomo.
Indlela iziguli ezikhetha ngayo phakathi kwama-ORAL and Topical NSAIDs
Kusuka emibikweni emibili eshicilelwe eBrithani Medical Journal (BMJ) , kwacaca ukuthi isinqumo sokuthi ukufakwa kwe-NSAID, ngomlomo noma ngezobuciko, ukuthi kusetshenziswe ngokujwayelekile kuncike ku:
- ukubonwa ngesineke ngengozi yemiphumela emibi
- ukuba khona kwesinye isifo
- izinga lobuhlungu
- iseluleko esitholiwe
- okwenzayo (izindleko nokulula ukusetshenziswa)
Ku- BMJ , abacwaningi baphetha ngokuthi "ama-NSAID angama-topical ayindlela ephephile, ephephile kuma-NSAID omlomo okwelashwa kwe- knee osteoarthritis , ngisho noma umphumela we-placebo uchaza inani elikhulu lala ma-topical agents."
Ngokuvamile, xoxani nodokotela wakho ongakhetha kukho futhi usebenze ndawonye ukuze uthole ukuthi yikuphi okukhethwa kahle kwesimo sakho nesimo sakho.
> Imithombo:
> Ama-ORAL ehambisana nama-NSAID e-topical ngezifo zesifo se-rheumatic: ukufaniswa. Izidakamizwa. 2000 Sep; 60 (3): 555-74. U-Heyneman CA et al.
> I-Oral vs. NSAID yezobuchwepheshe zezinhlungu ze-OA - kanjani nokuthi kungani abantu bekhetha ukwelashwa. Disemba 5, 2007. > UKMiCentral >. NHS.