Isidakamizwa sinemiphumela ehlangene futhi manje isivinjelwe eYurophu
Abacwaningi baye bafunda uDiacerein ukubona ukuthi imithi inganciphisa yini ukuqhubeka kwe-osteoarthritis. Izidakamizwa eziguqula izifo ziyaziwa ukwelashwa kwesifo samathambo kanye nezinye izinhlobo zokuvuvukala kwamathambo. Kodwa izidakamizwa ezingase zishintshe ukuqhubekela phambili kwe- osteoarthritis , ukunciphisa umonakalo ohlangene nokunciphisa ithuba lokukhubazeka, zihlale zingavunyelwe.
Ngeshwa, i-Diacerein ayibonakali ukuthi izingozi zidlula izinzuzo zayo, futhi izifo zokwelashwa ezivamile ze-osteoarthritis azizange zinciphise lesi sifo ukusuka ekuthuthukisweni.
I-Treatment Usual Treatment Do not Slow Disease Progression
Izindlela zokwelapha ezingezona izidakamizwa ze- knee osteoarthritis kanye ne- hip osteoarthritis , amajoyina amabili aphethwe yi-osteoarthritis, afaka ukulahlekelwa isisindo, ukuvivinya umzimba nokugwema imisebenzi enesisindo okwandisa ukucindezeleka kumajoyini.
Izidakamizwa kanye nezithako odokotela abasebenzisa ukwelapha i-osteoarthritis zifaka ukungenisa okune-vitamin D okwanele; ama-analgesics afana neTylenol ; Ama-NSAID (izidakamizwa ezingezangezobuhlungu ezingekho emthethweni) ezifana ne-naproxen ne-ibuprofen; zinezela njenge- glucosamine sulfate ; kanye nama- joint injection . Ezinye izindlela zokwelapha nazo ziphakathi kwezinketho ezithandwa ukwelashwa. Ngaphandle kokulahlekelwa isisindo, akubekho ubufakazi obuqinekile bokuthi lezi zindlela zokwelashwa ziphuza noma zivimbela i-osteoarthritis.
Izifundo zeDiacerein njenge-Osteoarthritis Disease-Modifier
Ucwaningo luye lwahlola amandla okusebenzisa i-diacerein ukuphatha i-osteoarthritis yamadolo nezinkalo. I-Diacerein iyi-anti-inflammatory imithi esebenza ngokungafani ne-NSAIDS ejwayelekile. I-Diacerein ivimbela i-interleukin-1, ngokumelene nokuvimbela indlela ye- cyclooxygenase (COX) njengoba ama-NSAID enza.
Ezicwaningweni, iziguli zithola imithi ye-50 mg ye diacerein kabili ngosuku. Ngo-2006, i-Cochrane Collaboration yanyathelisa ukubuyekezwa kwezifundo eziyisikhombisa zempilo ezibandakanya i-diacerein ezihlanganisa iziguli ezingu-2,069. Yaphetha ngokuthi i-diacerein yaba nethonya elincane ekuthuthukiseni ubuhlungu nasekunciphiseni ukuqhubeka kwe-osteoarthritis uma kuqhathaniswa nokwelashwa okujwayelekile nama-NSAID noma i-placebo. Umphumela ovame kakhulu ohlangene ne-diacerein wawuhudo.
I-Cochrane Collaboration ivuselele ukubuyekezwa okuhlelekile ngo-2013, enezela izilingo ezintathu ezintsha zabahlanganyeli abangu-141. Ucwaningo olusha luqinisekisile ukuthi amandla obunikazi bokuphumelela komphumela we-diacerein ayephansi ukulinganisa, futhi ukunciphisa ubuhlungu kwakuncane. E-osteoarthritis ye-hip, kwakukhona inzuzo encane yokunciphisa isikhala esihlangene sokunciphisa, kodwa kungenzeka ukuthi akufanelekile emtholampilo. Kunengozi engamaphesenti angama-24 okuthuthukisa isifo sohudo ngenxa yomsebenzi we-diacerein.
I-European Medicines Agency ibeka izivimbelo
Ngomhla ka-19 kuNhlangulana 2014, iQembu Lokudidiyela Lokuqashelwa Kwemigomo kanye Nezinqubo Ezizimele - I-Human (CMDh) yokuvimbela i-diacerein e-European Union. Lesi sinqumo sibophe ngokusemthethweni ngo-Septemba 4, 2014. Leli qembu lisekelwe isinqumo salo engozini yeziguli ezenza uhudo olunamandla nezinkinga zesibindi ngenxa yomuthi.
Ngamafuphi, leli qembu linquma ukuthi izingozi ze-diacerein zazingaphezu kwezinzuzo zayo.
Ingabe Ucwaningo Olubanzi NgoDiacerein Ludingeka?
Isazi se-Rheumatologist uDkt. Scott J. Zashin sixoxe nge-diacerein njengendlela yokwelashwa kwe-osteoarthritis. "Ngalesi sikhathi, abukho ubufakazi obucacile bokuthi i-diacerein ikhiqiza imiphumela ephawulekayo njengesidakamizwa sokuguqula isifo se-osteoarthritis," etshela. "Ucwaningo olwengeziwe luyadingeka ukuze kutholakale ukuphepha okufushane nokude kwesikhathi eside ne-diacerein ye-osteoarthritis."
Isidakamizwa asikho e-United States, i-European Union, eCanada, eBrithani, noma e-Australia. Kungatholakala emazweni akhethiwe, ngokuya komthethonqubo oqhubekayo.
Isinqumo sika-2014 se-European Union sokuvimbela lesi sidakamizwa sibonisa ukuthi imiphumela emibi yalokho okudalwa yilezi zidakamizwa kunzima kunanoma yiziphi izinzuzo ezikhona.
Imithombo:
Fidelix TS, Soares BG, iTrvisani VF. "Diacerein ye-osteoarthritis." I-Cochrane Database Syst Rev. 2006 Jan 25; (1): i-CD005117.
UFidelix TS, iMakedoniya CR, uMalewell LJ, uFernandes Moça Trevisani V. "I-Diacerein ye-osteoarthritis." I-Cochrane Database Syst Rev. 2014 Feb 10; 2: i-CD005117. i-doi: 10.1002 / 14651858.CD005117.pub3.