Izingozi nemiphumela emibi ye-Celebrex yokwelashwa kwe-migraine
Igama le- celebrex - igama elijwayelekile celecoxib - luhlobo lwe-nonsteroidal anti-inflammatory noma i- NSAID . Isebenza ngokulwa nokuvuvukala kwe-prostaglandin emzimbeni, ngaleyo ndlela ukunciphisa ubuhlungu. Nakuba ngokuvamile esetshenziselwa ukwelapha i- arthritis , odokotela abathile banikeza i-Celebrex ngemigraines enzima.
I-Celebrex ihluke kanjani ku-NSAID yendabuko?
I-celebrex ihlose i-enzyme emzimbeni obizwa nge-COX-2, ophethe ukuvuvukala emzimbeni.
Ngakolunye uhlangothi, i- Ibuprofen ne-naproxen, bahlose kokubili ama-enzymes COX-2 ne-COX-1 - ngakho kuthiwa ama-NSAID angakhethi. I-COX-1 iyi-enzyme esiza ukugcina ubuningi besisu kanye namathumbu.
Ngenkathi i-NSAID inganciphisa ubuhlungu nokuvuvukala ngokukhomba i-COX-2, futhi ingabangela ukulimala esiswini nasemathunjini emathumbu emathunjini, okuholela ekukhenikeni kwamathumbu kanye nezilonda. Ngokukhomba ngokukhetha i-COX-2, i-Celebrex inciphisa ingozi yezinkinga zesisu nesisu somzimba.
Ingabe I-Celebrex Inqunywe Izifo Ze-Neurologists ze-Migraines?
Ngisho noma ama-NSAID abhekwa njengendlela yokwelapha yokuqala emigqeni emibi, kusekhona ukuqapha okusetshenziswe odokotela abaningi ekudaleni i-Celebrex. Lokhu kubangelwa ukuhoxiswa kwamanye ama-inhibitors e-COX-2 avela emakethe, njengo-Vioxx (rofecoxib), ngenxa yokuhlangana kwabo nezinkinga zenhliziyo.
Manje zonke i-NSAID, kuhlanganise ne-Celebrex, ithwala isixwayiso sebhokisi ngenhlekelele eyengeziwe yokugula kwesifo senhliziyo, njenge-heart attack and stroke.
Lokhu kuthiwa, i-Celebrex ingase ibe yindlela yokwelashwa ehlukile ekwelapheni ama-migraine acute, ikakhulukazi kubantu abasengozini yokulimala kwe-NSAID esiswini nasezintweni zabo. Ukusekela le ngqungquthela, isifundo esisodwa sonyaka ka-2007 eSingapore Medical Journal sathola ukuthi u-400mg we-celecoxib wayilingana no-550mg naproxen ekunciphiseni ama-migraines acute - kanti i-celecoxib yabangela ubuhlungu obungaphansi kwesisu kunase-naproxen.
Yini Abanye Ababuza Ngodokotela Wakho Ongakubuza?
Njenganoma yimiphi imithi, kubalulekile ukuxoxa ngazo zonke izingozi kanye nemiphumela emibi nodokotela wakho. Nazi izibonelo zemibuto embalwa udokotela wakho angakubuza:
- Yimiphi eminye imithi oyithathayo? Eminye imithi ixhumana noCelebrex noma ibuhlungu kakhulu emandleni ayo.
- Ingabe unayo yonke imithi? Isibonelo, akufanele uthathe i-Celebrex uma une-asthma, imisipha, noma isenzo sokuthi uhlaselwe yi-NSAID esikhathini esidlule.
- Unayo izinkinga zempilo? Isibonelo, i-Celebrex akufanele inikezwe ngaphambi kokuhlinzwa noma kokuhlinzwa kwenhliziyo.
- Ukhulelwe? I-celebrex akufanele isetshenziswe ngezigaba zokukhulelwa kamuva.
Imiphumela Emibi Ye-Celebrex
Lokhu kudinga ukuba uxhumane nodokotela wakho ngokushesha bese ufaka:
- Ukusabela okunomsoco (ukuphefumula kanzima; ukuvala umphimbo wakho; ukuvuvukala kwezindebe zakho, ulimi, noma ubuso; noma imifuba)
- Ubuhlungu besisu, isisa, noma ukunganaki
- Izitembu ezigazini, ezimnyama, noma ezilindile
- I-nausea noma i-heartburn
- Ukuhlanza igazi
- Ukuzuza kwesisindo esingachaziwe
- Ukuthumba noma ukugcinwa kwamanzi
- Ukukhathala okungavamile noma ukuphelelwa amandla
- Ukushisa isikhumba noma ukushaya
- I-Yellowing yesikhumba sakho noma amehlo
- "Izimpawu ezinjenge-Flu"
- Ukulimaza okungavamile noma ukuphaphaza
Ngenxa yengozi engase ibe yingozi yokuhlasela kwenhliziyo kanye nokushaywa yi-Celebrex namanye ama-NSAID angewona ama-aspirin, njenge-ibuprofen ne-naproxen, kubalulekile ukufuna usizo lwezokwelapha ngokushesha uma uzwa ubuhlungu besifuba, ukuphefumula izinkinga, ubuthakathaka endaweni eyodwa noma eceleni umzimba, noma inkulumo emisiwe.
Okunye eminye imiphumela emibi kakhulu engase ibe khona ihlanganisa flatulence, isifo sohudo, isizungu, izimpawu ezibandayo. Kubalulekile ukuxhumana nodokotela wakho uma ubona noma yikuphi ukulimala okuphazamisayo, okuphikisanayo, noma okuphathelene nawe noma abanye.
Kusho ukuthini lokhu?
Uma udokotela wakho ebeka i-Celebrex ngemigraines yakho, ungayithola isisindo esiswini sakho kune-Aleve (naproxen) noma i-Motrin (ibuprofen).
Imithombo
I-American Academy ye-Neurology. Izinkombandlela Ezisekelwe Ezingqinisweni Zokuphathwa Kwezinhlungu ze-Migraine ekuHlweni Kwezinsizakalo Eziyinhloko: Ukuphathwa Kwemithi Yokuhlasela Okumangalisayo. Ibuyiswe ngomhla kaDisemba wesibili, 2015.
I-FDA. I-FDA ivumela izinguqulo zokuqala zama-celecoxib. Ibuyiswe ngomhla kaDisemba wesibili, 2014.
I-Hawkey CJ. I-COX-1 ne-COX-2 inhibitors. I-Best Pract Res Clin Gastroenterol. 2001 Oct; 15 (5): 801-20.
Loder E, Burch R, Rizzoli P. Imihlahlandlela ka-AHS / AAN ka-2012 yokuvimbela i-migraine ye-episodic: isifingqo futhi kuqhathaniswa nezinye iziqondiso zomkhuba zamuva. Izinwele . 2012; 52: 930-45 .
Loo CY, Tan HJ, Teh HS & Raymond AA. I-randomized, ilebula evuliwe, isilingo esilawulwayo se-celecoxib ekwelapheni ukuhamba okunamandla. I-Singapore Med J. 2007 Sep; 48 (9): 834-9.
Ukuphathwa kwe-US nokuDrug. (Julayi 9, 2015). I-FDA Ukuphathwa Kokuphepha Kwezidakamizwa: I-FDA iqinisa isixwayiso sokuthi izidakamizwa ezingezona-aspirin ezingavumeli ukuvuvukala (i-NSAID) zingabangela ukuhlaselwa yinhliziyo noma imivimbo.
Ukuphathwa kwe-US nokuDrug. Umhlahlandlela Wezokwelapha Wezidakamizwa Ezingafuni Ukuvimbela Izidakamizwa (Non-Steroidal Anti-Inflammatory) (NSAIDs).