Izimpawu ze-CAH I-Mimic PCOS
Uma ucabangela ukuxilongwa kwe-polycystic ovary syndrome (i- PCOS ), kuyinto evamile ukuba udokotela acabange ukuthi sekuphelile isikhathi sokubeletha esibelethweni se-adrenal hyperplasia (CAH). Lokhu kungenxa yokuthi lezi zifo ezimbili zivame ukuveza izimpawu ezifanayo.
Ukuhamba kwesikhathi esilandelayo i-Congenital Adrenal Hyperplasia
I-hyperplasia engama-congenital i-congenital i-group yezifo lapho i-enzyme eyinhloko ilahlekile emzimbeni.
Izisulu zokubeletha ezisekhona ngesikhathi sokuzalwa (kokuzalwa) zithinta ama-enzyme amaningana adingekayo ukuze akhiqize ama-hormone adrenal ama-cortex abalulekile.
Amaphesenti angama-95 ama-CAH amacala abangelwa ukungabikho kwe-enzyme 21-hydroxylase. Umzimba awukwazi ukwenza inani elanele lamakhomoni amabili e-adrenal steroid-cortisol ne-aldosterone-lapho i-enzyme 21-hydroxylase ilahlekile noma isebenza ezingeni eliphansi. Lokhu kulahla ukulinganisela kwama-hormone, ukuvimbela ukuhlanganiswa okufanele kwe-aldosterone ne-cortisol, futhi i-cortex ye-adrenal iqala ukwenza i-androgens (ama-hormone wesilisa ama-steroid), okuholela ezicikweni zamadoda kubantu. Kule ndlela ye-classic ye-CAH, ukulinganisa usawoti nakho kungashintsha ngokuphawulekayo, okuholela ekungalingani kwe-electrolyte, ukuphelelwa amandla kwamanzi nokuguquka komzimba.
Nakuba iziguli eziningi zitholwa ngokushesha ngemva kokuzalwa, kunesifo salesi sifo esivela esikhathini esithile ekuphileni, ngokuvamile ekukhuleni noma ekukhulile-kubizwa ngokuthi yi-CAH engeyona ye-classic noma ephuzile.
Laba bantu balahlekelwa ezinye ze-enzyme ezidingekayo ekukhiqizeni i-cortisol. Ukukhiqizwa kwe-Aldosterone ayithinteki, ngakho-ke leli fomu lesifo libi kakhulu kunefomu lokuzalwa futhi libonisa izimpawu ezivame ukungalungi nge-PCOS, njenge:
- Ukuthuthukiswa kwangaphambi kokushisa kwezinwele
- Izikhathi ezingavamile zokuya esikhathini
- I-Hirsutism (izinwele zomzimba ezingafuneki noma ezidlulele)
- I- acne ejulile (ebusweni kanye / noma emzimbeni)
- Izinkinga zokuzala emaphesenti angu-10 kuya ku-15 amaphesenti abesifazane abasha abane-CAH
Ukuxilongwa kwe-CAH
I-congenital adrenal hyperplasia iyadluliselwa izakhi zofuzo. AmaJuda aseMpumalanga Yurophu (Ashkenazi) abe nengozi eyengeziwe yokuba nalesi sifo, uma kuqhathaniswa nomphakathi jikelele. Njengoba i-CAH iyisifo esiphezulu se-autosomal , bobabili abazali kufanele baphathe imfanelo enzyme enesici ukuze bayidlulisele emntwaneni wabo.
Ngenxa yokudluliswa kwezakhi zofuzo, abantu abaningi bayazi ingozi emndenini wabo futhi bazise udokotela wabo ngesidingo sokuhlola izakhi zofuzo. Udokotela angase asebenzise umchamo kanye nokuhlolwa kwegazi ukuze afune amazinga ajwayelekile e-cortisol noma amanye amazinga e-hormonal. Amazinga we-androgen akhula nawo angacatshangwa uma ehlonza. Irekhodi lomlando eliphelele lomndeni kanye nokuhlolwa komzimba nakho kuyadingeka ukuba udokotela akwazi ukuxilongwa ngokuphelele.
Izinketho zokwelapha
Amaphilisi okulawula ukubeletha ngokuvamile asebenza kahle ekulawuleni umjikelezo wokuya esikhathini, ukunciphisa induna, futhi ngezinye izikhathi ukulahleka kwezinwele okungavamile. Uma lokhu kungaphumeleli ekusebenzelaneni nezimpawu, noma udokotela uzizwa ukuthi amaphilisi okulawula ukubeletha akufanelekile, angase acabangele ukukunika ukwelashwa okuphansi kwe-dose steroid.
Kodwa-ke, ukwelashwa akuvamile ukwenza impilo yonke.
Kubantu abane-CAH ye-classic abanesifo se-aldosterone, umuthi onjenge-fludrocortisone (i-Florinef) uzogcina usawoti emzimbeni. Izinsana nazo zithola usawoti wokufakelwa (njengeziphilisi ezichotshoziwe noma izixazululo), kanti iziguli ezindala ezinezinhlobo ze-CAH zidla ukudla okusawoti.
Isidakamizwa esithile kanye ne-regimen ngokuvamile kuya ekuqaphelweni kukadokotela wakho futhi kuncike ebuqilini bezimpawu.
> Umthombo:
> I-National Adrenal Diseases Foundation. I-Congenital Adrenal Hyperplasia (CAH).