Imithi Yezokwelapha Ama-Hormone Antidiuretic (ADH) Yokunciphisa Izingozi
Imithi yokwelapha i-desmopressin (ngezinye izikhathi ebizwa ngokuthi i-DDAVP) yisidakamizwa esilinganisa i-hormone emzimbeni emzimbeni futhi isetshenziselwa ukuphatha i-enuresis yelanga , kanye nezinye izimo. Uma ukwelashwa kokuziphatha kungaphumeleli, i-desmopressin iyisidakamizwa esisebenzayo kakhulu ukusiza izingane ziyeke ukumisa umbhede. Iyini i-desmopressin, isebenza kanjani, futhi yimiphi imiphumela emibi engaba khona?
Ukusetshenziswa
I-Desmopressin isetshenziswe kaningi ukuphatha imibhede ebantwaneni abaneminyaka eyisithupha noma ngaphezulu. Kulesi simo, ukuvinjelwa kwamanzi okuphuza kumele kuhambisane nokuphathwa kwemithi ngesikhathi sokulala. Lo mkhawulo ngokuvamile uvame ukunyuka kusuka ehoreni elilodwa ngaphambi kokuba uthathe i-desmopressin kuze kube ngakusasa ekuseni (noma cishe amahora ayisishiyagalombili emva kokuba umuthi uthathwe).
I-Desmopressin isetshenziselwa ukuphatha ezinye izimo ezingavamile, kufaka phakathi:
- Isifo sikashukela esiphakathi insipidus (ukukhiqizwa komchamo wokuhlanza)
- I-Hemophilia A
- Ukuphuma kwegazi
- Thayipha isifo se-Willebrand esingu-1
Isebenza kanjani?
I-Desmopressin iyisidakamizwa esilinganisa i-hormone engokwemvelo emzimbeni obizwa nge- antidiuretic hormone . Ngakho-ke, iyakwazi ukunciphisa i-diuresis noma ukukhiqizwa komchamo ezintsheni ezigcina zihanjiswe esibhedlela.
Ngaphezu kwalokho, i-desmopressin ikhulisa amakhemikhali egazini elibizwa ngokuthi i-Factor VIII ne-von Willebrand factor, okubalulekile ukuyeka ukuphuma kwegazi nokuthuthukisa ama-clots.
Lokhu kuchaza ezinye izindima zayo ngaphezu kokwelapha ukulala.
Ubani Okungafanele Asebenzise i-Desmopressin?
I-Desmopressin akufanele isetshenziselwe ukwelapha i-bedwetting ezinganeni ezincane kuneminyaka eyisithupha ubudala. Ngaphezu kwalokho, imithi akufanele isetshenziswe ngezikhathi zokugula ezingase zithinte ukungena kwamanzi noma ukulinganisa kwamandla kagesi (njengokudoba noma ukuhlanza).
Ngaphezu kwalokho, abantu abanezinkinga zezinso, umlando we-sodium ephansi (okuthiwa i-hyponatremia), noma u-von Willibrand uhlobo lwe-IIB akufanele lisebenzise i-desmopressin.
Kunezinye izimo eziningana lapho i-desmopressin kufanele isetshenziswe kuphela ngokuqapha, kufaka phakathi isifo se-coronary, isifo esiphakeme segazi (ukushisa komfutho wegazi), ukungalingani okuketshezi noma ukwenziwa kwe-electrolyte, i-polydipsia (ukuphuza ngokweqile), i-cystic fibrosis, ingozi ye-clothing (thrombosis), futhi ezigulini asebekhulile.
I-Desmopressin inekhono lokusebenzisana nezinye izidakamizwa eziningi, ngakho imithi yamanje kufanele ibuyekezwe ngokucophelela ngumhlinzeki wakho wezempilo ngaphambi kokuba uqale ukuyisebenzisa.
Imiphumela Ejwayelekile Ejwayelekile
Kunezinto ezimbalwa ezingase zibe nemiphumela emibi ngokusetshenziswa kwe-desmopressin. Nakuba kungenakulindeleka ukuthi umuntu abe nemiphumela emibi kakhulu - futhi kungenzeka ukuthi angenayo noma yimuphi - okunye okungahle kwenzeke nge-desmopressin kufaka:
- Ukuqhuma
- Ama-Chills
- Izinwele
- Isizungu
- Ukucasuka kweso (conjunctivitis)
- Intukuthelo ye-nasal (rhinitis)
- I-Nosebleeds (i-epistaxis)
- Isikhukhula
- I-nausea
- Ubuhlungu besisu
Ukusabela Okubalulekile Okungenzeka
Ngokusetshenziswa kwanoma imuphi umuthi, kuhlanganise ne-desmopressin, kunengozi yemiphumela emibi kakhulu. Lokhu kwenzeka okungavamile kakhulu, kodwa okunye okungase kwenzeke nokusetshenziswa kwe-desmopressin kufaka:
- I-sodium ephansi (hyponatremia)
- Ukudakwa kwamanzi
- Ukuzizwa
- I-Anaphylaxis (ukusabela okunzima kakhulu okubandakanya ukuphefumula okunzima)
- Ukuvala (thrombosis)
Ukuphepha nokuqapha
Njengoba kuphawuliwe ngenhla, abantu abathile kufanele basebenzise i-desmopressin ngokuqapha noma cha. Njengoba imithi isebenza ezinso, kubalulekile ukusetha umsebenzi ojwayelekile wezinso ngokulinganisa i-creatinine egazini lakho ngaphambi kokuqala imithi.
Uma uhlangabezana nanoma yikuphi ubunzima ngokusetshenziswa kwe-desmopressin, kufanele ube noxhumana naye oseduze nomhlinzeki wakho wokunakekelwa kwezempilo oyinhloko.
Umthombo:
"Desmopressin." I-Epocrates Rx Pro. Inguqulo 3.16, 2011. Epocrates, Inc. San Mateo, California.