Ukusetshenziswa kwezidakamizwa, ukucutshungulwa, nokuphambene
I-Epzicom iyinhlanganisela ehlanganisiwe yemithi esetshenziselwa ukwelashwa kwe-HIV, enamalungu amabili e- antiretroviral , abacavir (Ziagen) plus lamivudine (i-Epivir). Zombili izidakamizwa ezikhona zihlukaniswa njenge-nucleoside reverse transcriptase inhibitors (NRTIs) futhi zisebenza ngokuvimbela i-enzyme edingekayo ukuqedela ukuhlanganiswa kwe-DNA egazini esitokisini esithathelelekile.
Ngokwenza kanjalo, i-HIV ayikwazi ukuphindaphinda iphinde isakaze kwamanye amaseli.
I-Epzicom ivunyelwe ukusetshenziswa kubantu abadala yi-US Food and Drug Administration (FDA) ngo-Agasti 2, 2004. Ngaphandle kwe-US, lesi sidakamizwa sithengiswa ngaphansi kwegama lokuhweba elithi Kivexa .
Ukwakhiwa kwezidakamizwa
I-Epzicom iyatholakala kwifomu yethebulethi nge-600mg ye-abacavir ne-300mg ye-lamivudine. Amaphilisi aqoshwe ngefilimu ayesimo se-oblong esimeni, i-orange, futhi enziwe nge "GS FC2" ngakolunye uhlangothi.
Izilinganiso
Ithebulethi eyodwa nsuku zonke ithathwe ngomlomo noma ngaphandle kokudla. I-Epzicom ayisetshenziswanga yedwa futhi kufanele isetshenziswe ekwelashweni okuhlangene nomuthi owodwa noma ngaphezulu we-antiretroviral.
Imiphumela Ejwayelekile Ejwayelekile
Imiphumela emibi kakhulu ehambisana nokusetshenziswa kwe-Epzicom (okwenzeka ngamacala angu-9%) kufaka:
- Ukuxhaswa kwezidakamizwa ( bheka ngezansi )
- Ukungalali
- Ukucindezeleka
- Ikhanda / i-migraine
- Isizungu
- I-nausea
- Uhudo
- Rash
- Fever
- Ubuhlungu besisu
Iningi lezimpawu ngokuvamile lihlala isikhathi eside nakuba abantu abanezibonakaliso ze-drug hypersensitivity kufanele bafune ukwelashwa ngokushesha.
Isixwayiso se-Drug Hypersensitivity
Ngezinye izikhathi ukuxilongwa kwezidakamizwa kuphawulwe ezigulini ezivezwe ezihlakalweni ezidakamizwa ze-abacavir futhi zingaba zibulalayo uma zishiywe zingalashwa. Kubonakala ngamacembu ama-almathi amahlanu alandelayo noma ngaphezulu:
- Fever
- Rash
- Izimpawu zesisu (isicanucanu, isifo sohudo, ukuhlanza, ubuhlungu besisu)
- Ukukhathala, i-malaise, ukukhathala, ubuhlungu be-muscular / joint
- Izimpawu zokuphefumula (ukuqala ukukhwehlela ngokuzumayo, ukuphefumula, ukuphuza komlomo)
Izimpawu ze-hypersensitivity ngokuvamile zivela emavikini ayisithupha okuqala okuvezwa, nakuba zingabonakala kunoma yisiphi isigaba sokusetshenziswa kwezidakamizwa. Kodwa-ke, ngokuvamile, izimo eziningi ze-hypersensitivity zenzeka ezinsukwini eziyishumi zokuqala noma ngaphezulu.
Uma kucatshangwa ukuthi i-hypersensitivity, i- Epzicom kufanele imiswe ngokushesha . Iziguli kufanele zithinte ngokushesha nodokotela wazo kanye / noma uye emtholampilo oseduzane noma emakamelweni okuphuthumayo ngaphandle kokulibala.
Ngaphambi kokuqala ukwelashwa nge-abacavir, odokotela bayelulekwa ukuthi bahlolwe ukuthi i-HLA-B * 5701 iphelele njengoba iziguli ezine-genetic allele ziyaziwa ukuthi zingengozi enkulu ye-abacavir hypersensitivity.
Ucwaningo lwezokwelapha luye lwabonisa ukuthi cishe iziguli ezingu-8% ku-abacavir zizobhekana nokusabela okuxilisayo, ngezinye izikhathi ezibucayi.
Ukungafani
- I-abacavir hypersensitivity yangaphambili yangaphambili: Iziguli ezine-hypersensitivity reaction response (Ziagen) abacavir akufanele zibekwe u-Epzicom.
- Ukukhubazeka kwesibindi: Iziguli ezinokukhubazeka kwe-hepatic (isibindi) kufanele zigweme i-Epzicom. Sicela ukweluleka udokotela wakho uma unecala lokukhubazeka kwesibindi, noma uma usulelekile (noma usolwa ukuthi unesifo) nge-hepatitis A, i-hepatitis B, noma i- hepatitis C. Ukwehla okukhulu kwe-hepatitis B kuye kwabikwa ngeziguli ezithintekayo nge-HIV, kuyilapho ezinye iziguli ezithinta izifo ze- hepatitis C eziqukethe i-interferon kanye / noma i-ribavirin zingase zizwe izimpawu ezimbi.
Ukusebenzisana kwezidakamizwa
- U-Ethanol (ukuphuza utshwala): unciphisa ukuqeda abacavir ohlelweni
- I-Methadone (esetshenziselwa ekwelapheni umlutha wezinyosi): yehlisa ukusebenza kwe-methadone kwinani elincane lesiguli
Kunconywa ukuthi iziguli zinciphise utshwala ngesikhathi ku-Epzicom, kuyilapho iziguli eziseMethadone kufanele zeluleke udokotela wazo uma ngabe i-Epzicom inqunywe.
Ukucatshangelwa Ukwelashwa
Iziguli ezinokukhubazeka kwezinsolo (izinso) azifanele zibekwe i-Epzicom uma imvume ye-creinine ingaphansi kwe-50mL / iminithi. Ezigulini ezinengozini yokungasebenzi, zibandakanya imvume yokudalulwa kwe-creinine, i-serum phosphorus, i-glucose yomchamo kanye ne-protein yomchamo uma uqhuba ukuhlola okujwayelekile .
Ngenkathi ezinye izilwane zezilwane ziphakamisa ukuthi ingozi ephezulu yokwanda kwezingane ezitholakala emagatsheni kanye nonogwaja evezwe ku-abacavir noma i-lamivudine, akukho ukuhlukana okunjalo kuye kwabikwa kwabesifazane abakhulelwe abadonsela kulezi zidakamizwa ngokumelene nalabo abahlala emphakathini.
Ezweni elithuthukile, Kunconywa ukuthi omama abanesandulela ngculaza bagweme ukubeletha ngenxa yengozi eyengeziwe yokudlulisela i-HIV ezinganeni zabo.
Imithombo:
I-US Food and Drug Administration (FDA). "I-FDA ivumela ukuhlanganiswa okubili okuyi-Dose-Dose Products for the Treatment of HIV-1 Infection." I-Silver Spring, e-Maryland; ikhishwe ngo-Agasti 2, 2004.