Imishanguzo ivimbela igciwane lesandulela ngculazi ekuqotheni ama-Genetic Machinery
Ukuhlukaniswa
I-Vitekta (elvitegravir) iyisidakamizwa se- antiretroviral esichazwa njenge- integrase inhibitor esetshenziselwa ukwelashwa kwe- HIV . I-Integrase inhibitors isebenza ngokuvimbela i-enzyme ye-HIV ebizwa ngokuthi i-integrase, leyo i-HIV esebenzayo ukuze ihlanganise i-coding yayo ku-DNA yesitokisi. Ngokuvimbela integrase, igciwane alikwazi ukuqedela umjikelezo walo wokuphila futhi idale nezinye i-HIV virions.
I-Vitekta yamukelwa yi-US Food and Drug Administration (FDA) ngoSeptemba 2014 ukuze isebenzise kubantu abadala ngaphambili abavezwe ukwelashwa kwe-HIV.
I-Elvitegravir iyinhlanganisela yezinhlanganisela zomthamo ongenqunyelwe izidakamizwa zesidakamizwa Stribild (eyaziwa nangokuthi "i-Quad Pill") kanye ne-second generation generation of Stribild ebizwa ngokuthi i- Genvoya .
Ukwakhiwa kwezidakamizwa
I-Vitekta iyatholakala kumafomu amabili wethebulethi:
- I-tablet ye-85 mg ye-pentagon, eqoshwe ngefilimu, eluhlaza okwesibhakabhaka ne "GSI" ehlangothini olulodwa futhi "85" ngakolunye uhlangothi.
- Ithebulethi enemibala engu-150 mg, enekhamera elinefilimu, eluhlaza okwesibhakabhaka ne "GSI" ehlangothini olulodwa no- "150" kolunye.
Isilinganiso
I-Vitekta kumele isetshenziswe ngaso sonke isikhathi ekwelashweni okuhlangene kokubili i- HIV protease inhibitor (PI) kanye ne- Norvir (ritonavir) , i- agent evuselela " eyenza ukuhlushwa kwezidakamizwa ezihambisanayo egazini. I-Vitekta kumele ithathwe ngokudla.
Izinga eliphakanyisiwe lihluka ngokukhethwa kwezidakamizwa kanje:
| Isilinganiso se-Vitekta | Umthamo we-Protease Inhibitor | Isilinganiso se-Norvir (ritonavir) |
| 85mg kanye ngosuku | I-Reyataz (atazanavir) 300mg kanye ngosuku | 100mg kanye ngosuku |
| 85mg kanye ngosuku | I-Kaletra (i-loopinavir engama 400mg + 100 mg ritonavir) kabili nsuku zonke | Akudingeki ukuthi i-ritonavir isivele iqukethe ukubunjwa kwe-Kaletra |
| 150mg kanye ngosuku | I-Prezista (darunavir) 600mg kabili nsuku zonke | 100mg kabili ngosuku |
| 150mg kanye ngosuku | Lexiva (fosamprenavir) 700mg kabili nsuku zonke | 100mg kabili ngosuku |
| 150mg kanye ngosuku | I-Aptivus (tipranavir) 500mg kabili nsuku zonke | 200mg kabili nsuku zonke |
Imiphumela Ejwayelekile Ejwayelekile
Esifundweni sesigaba sesi-III somtholampilo, izibalo eziningana zezidakamizwa ezingase zibe khona ziye zabonwa ezigulini ezithatha i-Vitekta. Izenzakalo ezivame kakhulu, ezibikwe okungenani ezingu-2% zabahlanganyeli becala zifaka:
- Uhudo
- I-nausea
- Izinwele
Imiphumela emibi engavamile efaka ubuhlungu besisu, indigestion, ukushisa, ukukhathala nokuhlanza.Imiphumela emibi yayivame ukuphela kwesikhathi, kanti iziguli ezimbalwa ziyayeka ngenxa yokungabekezelelani ukwelashwa.
Ukuphikisana kwezidakamizwa
I-Vitekta akufanele ithathwe ngezidakamizwa ezilandelayo noma izithako ze-herbal:
- Imithi ye-Hepatitis C: Invicek, Victrelis
- Imithi yokulwa nesifo sofuba i-Rifampin: Rifater, Rifamate, Rimactane, Rifadin, Priftin (esikhundleni seMycobutin)
- Wort St. John's Wort
Njalo utshele udokotela wakho nganoma yisiphi isidakamizwa noma ukwesekwa, okushiwo noma okungenqunyiwe, ukuthi ungathatha ngaphambi kokuqala noma yiluphi ukwelashwa kwama-antiretroviral.
Ukusebenzisana kwezidakamizwa ze-antiretroviral
Ukusetshenziswa kweVitekta ngezidakamizwa ezilandelayo ezidambisigciwane kungaholela ekulahlekelweni komthelela wokwelashwa kwesidakamizwa esilandelayo noma ukwanda kwemiphumela emibi:
- I-Sustiva (efavirenz) akufanele iqondiswe nge-Vitetkta.
- I-Viramune (nevirapine) akufanele iqondiswe nge-Vitekta.
- I-videx (didanosine) kufanele ithathwe ihora elilodwa ngaphambi noma amahora amabili emva kwe-Vitekta dose.
- U-Tybost (i-cobicistat), i-agent ekhuthaza ukufana ne-Norvir, akufanele ithathwe nge-Vitekta uma ilawulwa nge-protease inhibitor.
Okunye okucatshangwayo
Ama-Antacids angavimbela i-Vitekta ukuba ingene kahle. Uma usebenzisa i-anti-counter antacid (isib. I-Rolaids, i-Tums, i-Milk ye-Magnesia), kuphakanyiswa ukuba kuthathwe amahora amabili ngaphambi noma ngemuva kwe-dose Evotaz.
Abesifazane kufanele banxuse udokotela wabo uma bethatha noma behlela ukuthatha amaphilisi okulawula ukubeletha. I-Vitekta, uma isetshenziswe ne-Norvir, inganciphisa kakhulu ukuhlushwa kwe-plasma ye- ethinyl estradiol / ne-norgestimate contraceptive contraceptive.
Kunconywa izindlela ezihlukile zokuvimbela ukuvimbela ukuvimbela ingane. Ungalokothi ukhulise ama-hormonal contraceptive dosages. Kunconywa ukuthi umama ongumhlengikazi angalusisi isisu uma enesandulela ngculazi njengoba kungenzeka ukuthi adlulisele igciwane entsheni.
I-Vitekta iqukethe i-lactose ngakho-ke qiniseka ukuthi uyeluleka udokotela wakho uma une-lactose engavumiyo.
Imithombo:
I-US Food and Drug Administration (FDA). "I- VITEKTA - ULWAZI LOKUPHILA OKUQHELEKILE ." I-Srpring yesiliva, e-Maryland; ifinyelelwe ngoFebhuwari 3, 2015.
I-FDA. "I-FDA ivumela iphilisi entsha yokuhlanganiswa kwegciwane lesandulela ngculazi kwezinye iziguli." I-Silver Spring, e-Maryland; ukushicilelwa okukhishwe ngo-Agasti 27, 2012.
I-Sciences yaseGileyadi. "I- Genvoya - Amaphuzu avelele okuchaza ulwazi." Foster City, California; ifinyelelwe ngoDisemba 14, 2015.