Imininingwana Yokunakekelwa Kwezinhlungu kanye Nemithi Yokuqapha
Ukuphumula ubuhlungu kuyinhloso yokwelapha oyinhloko yemithi ye-osteoarthritis. Ukuvuvukala kwendawo, okungahle kwenzeke nge-osteoarthritis, futhi kukhululeka ngokuthatha imithi ye-osteoarthritis.
Imithi ye-Analgesic
Ama-analgesics ayingxenye yezidakamizwa ezisetshenziselwa ukunciphisa ubuhlungu. Ama-analgesics akhuthaza ubuhlungu ngokuvimbela izibonakaliso zobuhlungu eziya ebuchosheni noma ngokuphazamisa ukuchazwa kobuchopho, ngaphandle kokukhiqiza i-anesthesia noma ukulahlekelwa ulwazi.
Kunezinhlobo ezimbili eziyinhloko zezi-analgesics: okungewona ama-narcotics kanye nezidakamizwa.
Ama-Analgesics angewona ama-narcotic
I-Acetaminophen yiyona yokwelashwa kokuqala ephakanyiswe yi-American College of Rheumatology yokwelashwa kwe-osteoarthritis, ikakhulukazi emaceleni nasemadolweni. Nokho, ezinye iziguli zingathola izidakamizwa ezingezona ukuvuvukala (NSAIDs) ezingasebenzi kakhulu ukuze ziphumelele ekuphuculeni ubuhlungu kune-acetaminophen. Kube khona izifundo nezimpikiswano eziphumelela kakhulu - i-acetaminophen noma i-NSAID? Isiphetho ukuthi ukukhethwa kwemithi kufanele kube ngabanye.
Ama-Narcotic Analgesics
Ngezinye izikhathi ama-analgesics ama-narcotic anikezwa iziguli ezine-osteoarthritis ezinzima eziye zahluleka ezinye izinketho zokwelapha. I-Ultram (tramadol) ayinayo i-narcotic kodwa isidakamizwa sinomsebenzi onjengo-narcotic kanye nezakhiwo zokunciphisa ubuhlungu. I-Ultram ibike ukuthi inciphisa ukusetshenziswa kwe-NSAID futhi ilawule ngokuphumelelayo ubuhlungu bokuphuza iziguli ze-osteoarthritis.
Ama-Analgesics e-Topical
Ama-analgesics aphezulu angama-creams noma amanye ama-rubs asetshenzisiwe asetshenziselwa ukuhlanganyela okuhlangene ngaphandle. Kuthengiswa phezu kwe-counter. Izithako ezisebenzayo zifaka:
- Ama-Counterirritants - amafutha e-wintergreen, i-camphor, i-eucalyptus
- Ama-salicylates
- I-Capsaicin
Izidakamizwa ezingavumelani nezidakamizwa ezingekho emthethweni (ama-NSAID)
Ama-NSAID aboniswe ukuthi asebenza kahle kwi-osteoarthritis ngezifundo ezihlukahlukene.
Njengoba i-NSAID eminingi inokuphumelela ngokulinganayo ekusizeni ubuhlungu, isinqumo iNSAID esingasisebenzisa singase sisekelwe ezindlekweni, esimisweni sesilinganiso, kanye nengozi yemiphumela emibi. Ingozi yokwehla kwamathumbu kanye nezinyosi, kanye nezingozi zenhliziyo, kumele ihlolwe ngokusetshenziswa kwe-NSAID.
Ama-NSAID afaka:
- I-Ansaid (i-Flurbiprofen)
- I-Arthrotec (i-Diclofenac / i-Misoprostol)
- I-Cataflam (i-Diclofenac potassium)
- I-Clinoril (Sulindac)
- I-Daypro (i-Oxaprozin)
- I-Dolobid (Diflunisal)
- UFeldene (Piroxicam)
- Ibuprofen (Motrin, Advil)
- Indocin (Indomethacin)
- I-Ketoprofen (i-Orudis, i-Oruvail)
- I-Lodine (i-Etodolac)
- UMeclomen (Meclofenamate)
- I-Mobic (i-Meloxicam)
- I-Nalfon (i-Fenoprofen)
- I-Naproxen (i-Naprosyn, i-Aleve)
- I-Ponstel (i-Mefenamic Acid)
- I-Relafen (Nabumetone)
- I-Tolectin (i-Tolmetin)
- I-Voltaren (i-Diclofenac Sodium)
I-COX-2 Inhibitors Ekhethiwe
I-COX-2 inhibitors ekhethiwe inezindlela ezincane zokwenza ubuthi lwezinyosi kunama-NSAID wendabuko. Udokotela wakho kufanele abheke izinzuzo ngokuhambisana nezingozi futhi ucabange nezindleko uma ukhetha i-NSAID engcono noma i-COX-2 inhibitor ngawe.
Ama-NSAID asebenza ngokuvimbela umsebenzi we-enzyme, i-cyclooxygenase, eyaziwa nangokuthi i-COX. Ucwaningo lwembula ukuthi kunezinhlobo ezimbili, ezaziwa njenge-COX-1 ne-COX-2. I-NSAID ithinta kokubili amafomu. I-COX-1 ibandakanyekile ekugcineni izicubu ezinempilo, kuyilapho i-COX-2 ibandakanyeka endleleni yokuvuvukala.
I-COX-2 inhibitors ekhethiwe yaba yi-subset ye-NSAID, futhi ukhetho olungcono lweziguli ezisengozini yokudla kwesisu.
Ngesinye isikhathi, kwakukhona ama-inhibitors angu-COX-2 akhethiwe emakethe: I-Celebrex, i-Vioxx no-Bextra. Nakuba ama-last amabili asusiwe emakethe, iCelebrex yiyona kuphela i-COX-2 inhibitor ekhethiwe etholakalayo.
Ukujola kwangaphakathi
Iziguli ze-osteoarthritis ezine-joint injusion noma ukuvuvukala kwendawo zingase zithole izijovo ze-corticosteroid zangaphakathi .
Omunye umjovo wendawo ongase uzuze iziguli ze-knees osteoarthritis kuhilela umjovo we-intra-articular we- hyaluronan noma izakhi (isib, Synvisc, Orthovisc , Hyalgan, Euflexxa, Supartz).
Le nqubo ibizwa ngokuthi i-viscosupplementation.
Imithombo:
I-Primer kuma-Rheumatic Diseases. Edition 12. Ishicilelwe yi-Arthritis Foundation. Osteoarthritis Ukwelapha Izinketho. I-Arthritis Foundation.