Indlela Ukucindezeleka Okuthinta Ukucindezeleka Kwegazi
Njengoba ukuqonda kwethu nge-biology ngemuva kokucindezeleka nezimo ezihlobene, kuye kwaziwa ukuthi izimo eziningi eziye zacatshangwa ukuthi ziyizimo zengqondo zinezixhumanisi eziqondile ekushintsheni kwezinto eziphilayo emqondweni. Ngenxa yalokho, ukwelashwa kokucindezeleka ngokuya kuncike ezidakamizwa ezenzelwe ukunciphisa izinga lamakhemikhali athile ohlelweni lwezinzwa.
Imithi eminingi esetshenziselwa ukuphatha umsebenzi wokucindezeleka ngokukhulisa inani le-serotonin noma i-dopamine etholakala emzimbeni. Lezi zimakhemikhali zilawula indlela amangqamuzana angaphakathi kobuchopho akhulumisana ngayo, futhi abuye alekelele ukuxhumanisa ukuxhumana phakathi kwezifunda ezahlukene zobuchopho. Amazinga aphansi e-serotonin ne-dopamine aye ahlotshaniswa nokuguqulwa kwemizwa, futhi izidakamizwa ezicindezelayo zenzelwe ukwandisa inani elitholakalayo lala makhemikhali.
Iyiphi Indima Yenza Ama-Neurochemicals Amakhemikhali Adlalwa Emzimbeni Ngaphandle Kobuntu?
I-Serotonin ne-dopamine badlala indima ebalulekile ezingxenyeni eziningi zomzimba ngaphandle kobuchopho, futhi izidakamizwa ezicindezelayo ziyasetshenziselwa ukuphatha izimo ezihlukahlukene ezifana nobuhlungu obungapheli. Zombili lezi zinhlanganisela ziyaziwa ukuthi zithinte inhliziyo nemithambo yegazi.
Ezingxenyeni ezigxilile, i-dopamine isetshenziswa njengesidakamizwa esiphuthumayo ukusekela (ukwandisa) umfutho wegazi ngesikhathi sokuhlinzwa futhi lapho izimo ezithile - njengokutheleleka komzimba wonke - ziholela ekucindezelweni kwegazi okuphansi okungaphezu kwamandla omzimba wokulungisa.
Ngezinga elincane, i-serotonin inezimo ezifanayo zokucindezela kwegazi-futhi ingandisa ukonakala kwehliziyo nezitsha kulemiphumela ye-dopamine.
Kuyini Ukukhathazeka Kwalabo Abathwala Ukucindezeleka?
Nakuba izidakamizwa zokucindezeleka zingakhulisi i-serotonin ne-dopamine emazingeni aphezulu, ukusetshenziswa kwazo kuye kwaziwa ngokuphakamisa ukucindezelwa kwegazi.
Ama-antidepressants akhethekile ahlanganiswe nokwanda kwengcindezi yegazi ahlanganisa:
- I-Venlafaxine (Effexor XR)
- I-Monoamine oxidase inhibitors
- I-Tricyclic antidepressants
- I-Fluoxetine (okungukuthi, i-Prozac, i-Sarafem)
Amazinga akhula we-serotonin ne-dopamine adlala indima ebalulekile endleleni lezi zidakamizwa eziphakamisa umfutho wegazi, kodwa mhlawumbe kuningi endabeni, futhi izindlela eziqondile zisabhekene nenye ingxoxo. Ukucabanga okwamanje ukuthi lezi zidakamizwa zandisa umsebenzi jikelele ohlelweni lwezinzwa, okungase kukhulise izimpawu ezithile (njengalabo abalawula ukucindezeleka kwegazi) ukuthi isimiso sezinzwa sithumela kuwo wonke umzimba.
Kubalulekile ukuqaphela ukuthi ukucindezeleka kuxhumene nomfutho wegazi ophansi (nokukhathazeka okuhlobene nomfutho wegazi ophezulu). Ngakho-ke, ngokulungisa ukucindezeleka okuyisisekelo, kulandela ukuthi ukucindezeleka kwegazi kungase "kuvamile" ngenxa yalokho, abanye abantu abangase bathambekele ekuhlaleni okujwayelekile noma okuncane okungavamile.
Ukuphathwa Kwegazi Nokucindezelwa Kwemithi
Uma une-high blood pressure, usengasebenzisa imithi yokuvimbela ukucindezeleka. Udokotela wakho angakhetha ukugwema izinhlobo ezithile zezidakamizwa zokucindezeleka, futhi cishe uzofuna ukuqapha ukucindezeleka kwegazi ngokucophelela ngesikhathi sokuqala ukwelashwa.
Abantu abaningi abanomfutho wegazi ophezulu bayakwazi ukusebenzisa ama-antidepressants avamile kakhulu ngaphandle kwezinkinga, kodwa abanye bangadinga ukulungiswa ohlelweni lwabo lokuphuza ukucindezelwa kwegazi.
Iziguli ezidinga i-anti-depressant, ukuthola imithi efanele - noma inhlanganisela yemithi - ingaba inqubo yokulinga-nephutha. Umgomo wanoma yiluphi uhlobo lwezokwelapha lungenxa yezinzuzo ezingaphezu kwezingozi noma imiphumela emibi. Uma imithi eyodwa ingasebenzi kahle kuwe, kunezinto eziningi ezitholakalayo ongazithola. Ukugcina inkhulumomphendvulwano evulekile kanye nokukhulumisana okuhle kanye nodokotela wakho odokotela kuyisihluthulelo.
Imithombo
Brent D, et al. Ukushintshela kwesinye i-SSRI noma kwi-venlafaxine noma ngaphandle kokwelashwa kokuziphatha kwengqondo kubantu abasha abanezinkinga zokucindezeleka kwe-SSRI: i-TORDIA isilingo esilawulwa ngokungahleliwe. I-JAMA. 2008 Feb 27; 299 (8): 901-13.
Linder AE, Diaz J, Ni W, Szasz T, Burnett R, Watts SW. I-reactivity ye-Vascular, ukutholwa kwe-5-HT, nokucindezelwa kwegazi ku-rat serotonin yokuthungatha i-rat. Am J Physiol Heart Circ Physiol. 2008 Apr; 294 (4): H1745-52. Epub 2008 Feb 8.