I-T4 / T3 Ukuphikisana Kwezidakamizwa Ze-Thyroid

Okuvamile, ukwelashwa okuvunyelwe ukuqondiswa kwe-hypothyroidism yi-hormone ye-thyroid esikhundleni sendlela yokwenziwa kwe-thyroid hormone thyroxine (T4). Le-synthetic thyroxine yaziwa ngokujwayelekile njenge-levothyroxine (futhi ngezinye izikhathi l-thyroxine, noma i-L-T4). Amanye ama-brand awaziwa kakhulu yi-Synthroid, Levoxyl, Tirosint , ne-Unithroid. Lezi zivame ukubizwa ngokuthi "izidakamizwa ze-T4."

Kodwa-ke, kukhona ubufakazi obandayo, ukuthi ezinye iziguli ze-thyroid aziphenduli ekusetshenzisweni kwe-T4 kuphela, futhi zenze ngcono ngokungeziwe kwe-hormone yesithathu ye-thyroid, i-triiodothyronine (T3). Ifomu lohlobo lwe-T3 lwaziwa ngokujwayelekile njenge-liothyronine, futhi igama legama e-US yi-Cytomel. Lezi zibizwa ngokuthi "izidakamizwa ze-T3."

Amafomu ezemvelo, ezitholwa yizilwane zombili T4 no-T3 nazo zitholakala emtholampilo yemithi ebizwa ngokuthi i-Natural Desiccated Thyroid (NDT), eyenziwe ngezigulane zegciwane zengulube ezomile. Ama-brand ajwayelekile ahlanganisa i-Nature-throid, i-WP Thyroid, ne-Armor Thyroid. E-US, i-generic ibizwa ngokuthi yi-NP Thyroid.

Njengoba kuphawuliwe, izinga elivamile, ukwelashwa okuvamile kwe-hypothyroidism yisidakamizwa se-levothyroxine kuphela. Ukwengezwa kwe-T3 emtholampilo we-levothyroxine / T4-kuphela - noma ukusetshenziswa kwezidakamizwa ze-NDT - kungqubuzana kanye nesihloko socwaningo oluqhubekayo nengxoxo. Le ngxabano yokwelashwa ihlolwe ngokuningiliziwe kulezi zihloko ezilandelayo eziyinhloko lapha.

Izidakamizwa ze-T3 zithuthukisa izinga lokuphila

Ucwaningo lwe-1999 olwakhulunywa ngalo eNew England Journal of Medicine lwathola ukuthi izinga lokuphila kwabantu abaphathwa nge-hypothyroidism lithuthukisiwe kakhulu ngokungezwa kwe-T3 izidakamizwa ku-levothyroxine kuphela.

Abacwaningi bathi "ukwelashwa ne-thyroxine kanye ne-triiodothyronine kwathuthukisa izinga lokuphila kweziguli eziningi."

Okuningi

Isifundo se-JAMA sika-2003 sithi i-T3 ayihlinzeki

I- Journal of the American Medical Association (i-JAMA) ibike ngo-2003 ngokucwaninga okuphikisanayo okungatholanga nzuzo ezigulini lapho i-T3 yengezwa ku-T4 kuphela.

Okuningi

UDkt. Ken Blanchard ku-Issue T4 / T3

Ngasekupheleni kukaDkt. Ken Blanchard, MD, PhD, umbhali wencwadi ethi What Your Doctor Akungakutsheli Ngayo nge-Hypothyroidism, ihlaziya isifundo se-JAMA sika-2003.

Okuningi

I-T4 / T3 Ukwelashwa Okukhethwe Iziguli Esifundweni

Umagazini ka-May 2005 we- Journal of Clinical Endocrinology ne-Metabolism kubika ucwaningo olubonisa ukuthi abantu abane-hypothyroidism bakhetha ukwelashwa kwe-T4 / T3 kuphela ekwelapheni kwe-T4 kuphela. Abacwaningi baphinde bathola ukuthi ukwelashwa okuhlangene kuhlobene nokulahlekelwa isisindo, kanti ukwelashwa kwe-T4 kuphela kuphela.

"Iziguli zithandana ukwelashwa kwe-LT4 / LT3 ehlangene nokwelashwa okuvamile kwe-LT4 ... Ukunciphisa isisindo somzimba kuhlotshaniswa nokwaneliseka ngemithi yokutadisha ... umphumela walolu cwaningo awuvimbeli ukuthi kungenzeka ukuthi ingxenye ethile yeziguli ingazuza ku-LT4 ehlangene / Ukwelashwa kwe-LT3. "

Okuningi

Ukudalwa Kwemvelo Kwezidakamizwa Ze-Thyroid Okuthathwa Kuphephile

Ucwaningo olwenziwa ngo-2003 olwenziwa uhulumeni wase-United States, ukuhlola iziguli ze-hypothyroid eWalter Reed Medical Center, kubike ukuthi izidakamizwa zemvelo ezithintekayo zemvelo (NDT) zaziyisiphephelo esiphephile ku-levothyroxine kuphela.

Okuningi

Imibukiso Yokufundwa IsiDanishi Yengeziwe T3 Ephakeme Ku-T4-Kuphela

Ucwaningo olunzulu olwakhulunywa ngalo kuyi- European Journal of Endocrinology , lubheke inkinga yezokwelapha okuphikisanayo nge-synthetic T3 njenge-supplement eya ku-T4-kuphela (levothyroxine) yokwelashwa kwe-hypothyroidism.Ucwaningo lwathola ukuthi ukuhlanganiswa kwe-T4 / T3 kuphakeme kune-T4 ukwelapha kuphela / levothyroxine ye-hypothyroidism.

Ukuthola okuyisisekelo:

Ingqikithi yezingu-49% zeziguli zikhethe ukwelashwa kokuhlanganiswa, futhi kuphela u-15% okhethwe ukwelashwa kuphela kwe-levothyroxine.

Okuningi

Ingabe Udinga I-T3 Ukuze Uzwe Kuhle?

Iziguli eziningi ze -roid zixhumana nathi lapha nasekhasini le-Facebook le-Thyroid Support, bese ubuza umbuzo ofanayo: "NginguSythroid (noma omunye umuthi we-levothyroxine onjengoLevoxyl) futhi angizizwa kahle. Yini engingayenza? " Yiziphi iziguli ze-thyroid ezidingekayo ezizibuzayo, kulesi simo, ukuthi: Ungakuzuza yini ngokungeziwe kwe-T3 eyengeziwe?

Okuningi

Ingabe Udinga i-T3 noma i-Natural Desiccated Thyroid?

Uma ngabe usebenzisa izidakamizwa ezithathelwanayo ze-hormone (ie, levothyroxine, noma i-Synthroid, Levoxyl, noma iTirosint brand) futhi azizwa kahle, kungenzeka ukuthi ungazuza ngokufaka i-T3, noma ukushintsha imithi ye-thyroid ehlanganisa i-T3 .

Okuningi

Ucwaningo olusha

Inothi elilodwa eliqinisekisayo kule mpikiswano mayelana nokwelashwa kwe-T4-T3 kuphela ne-T3 / T3 ye-hypothyroidism yisifundo esikhulu sokucwaninga okuhlelwe ngo-2018. Lolu cwaningo luzohlola izinhlobo ezahlukene, kufaka phakathi izinga lokuphila nokugculiseka kwesiguli, kanye nokuhlala njalo isimiso sokuhlolwa kwegazi, ngokuqhathanisa i-levothyroxine ngokumelene nevothyroxine kanye ne-T3, futhi ngokuqhathanisa nalezi zindlela ezimbili zokwelashwa ngokumelene nokwelashwa kwemvelo ekhishwe imvelo. Ucwaningo luzobuye luhlolisise ukusabalala kokuhlukahluka kofuzo, okubizwa ngokuthi i-polymorphism, engenza i-T3 iphumelele nakakhulu nakwezinye iziguli ze-hypothyroid. Lolu cwaningo oluningi oluphakathi, oluphindwe kabili-blind, olubuyekezwa kontanga, olwenzelwe futhi olulawulwa yizinye ze-endocrinologists ezihola phambili, futhi olwenziwe ngezikhungo eziphezulu zezokwelapha nezibhedlela, aluxhasiwe yizinkampani ezenza imithi. Lapho imiphumela ishicilelwe, lolu cwaningo luyakwazi ukushintsha ngokuphawulekayo iziqondiso zokwelapha ezisemthethweni ze-hypothyroidism, ngokubonisa ukuthi ukwelapha okuhlanganiswa kwe-levothyroxine / T4, T4 / T3, kanye nokwelashwa kwe-NDT kuphephile futhi kusebenza ngendlela efanayo. Ucwaningo lungabuye lubonise ukuthi ukwengezwa kwe-T3 kubangelwa izinga eliphakeme lokuphila kwabanye noma ngisho neningi leziguli ze-hypothyroid. Ucwaningo kufanele lubonise nokuthi i-polymorphism yezofuzo ixhunyaniswa nesidingo se-T3 njengengxenye yokwelapha. Hlala ubukele ulwazi oluningi!