I-thyroid yemvelo eyaziwa ngokuthi i-NDT, i-thyroid ye-extract, ne-porcine ye-thyroid-iyimithi ye-thyroid yegciwane elivela emthonjeni obomile wezingulube.
I-thyroid ekhishwe ngamanzi kwakuyisilonda sokuqala esakhiwe esetshenziswa ekwelapheni i-hypothyroidism futhi sitholakale isikhathi esingaphezu kwekhulu.
I-Shift eya ku-Levothyroxine
Phakathi nengxenye yokuqala yekhulu lama-20, isifo semvelo esihlotshiswe ngokwemvelo-okungukuthi, igama elibizwa ngokuthi i-Armor Thyroid-yilo kuphela ukwelashwa okutholakala nge-hypothyroidism.
Ngawo-1950, uhlobo lwe-thyroxine (T4) lwama-synthetic lakhiwa. I-Thyroxine ingenye yamahomoni amabili ayisihluthulelo iklabhu ye-thyroid iveza. Le-synthetic thyroxine yayaziwa ngokuthi i-levothyroxine, noma i-thyroxine, futhi yaphakanyiswa njengendlela yokwelashwa yansuku zonke yokwedlula i-hypothyroidism, uma kuqhathaniswa ne-thyroid eyakhiwe emvelo.
Ngokungafani ne-levothyroxine, okuyiyona inguqulo yokwenziwa kwe-hormone ye-T4, i-thyroid eyakhiwe yendalo iqukethe ama-hormone e-thyroid amakhulu-T4 (thyroxine) ne-T3 (triiodothyronine) -kubalwa ne-calcitonin, nezinye izakhi ezitholakala emgodini we- thyroid . I- gland evamile yegciwane ikhiqiza ngokuyinhloko i-T4 (i-hormone yokugcina) kanye ne-T3, futhi i-T4 iguqulwa ibe yi-T3, i-hormone esebenzayo, ukuze isebenziswe ngamaseli namathishu omzimba.
I-Levothyroxine yilokhu okhethwe ukwelashwa kwezwe elivamile lezokwelapha kusukela ekusungulweni kwalo. (Ezinye zezinto ezivame ukubizwa nge-levothyroxine zihlanganisa i-Synthroid, iTirosint , Unithroid, neLevoxyl).
Izidakamizwa zemithi ye-thyroid, ezifaka amagama emvelo, i-Nature-Throid, i-Thyroid WP, i-Armor Thyroid, ne-Acella's generic thyroid yezidakamizwa i-NP Thyroid, ihlale emakethe. Lezi zidakamizwa ziyaqhubeka ukudweba ukugxeka kanye nomlilo kusuka ezinyangeni ezivamile kanye nezinkampani eziphikisana nezidakamizwa, eziyibiza ngokuthi "zesikhathi esidala" futhi ziphelelwe yisikhathi.
Okwamanje, i-subset yeziguli ze-thyroid ziye zaqhubeka zikhetha ukwelashwa kwemvelo okwezemvelo phezu kwe-levothyroxine, cishe ngenxa yokuthi kukhona ama-hormone e- T4 no-T3 emvelweni we-thyroid, ehambisana ne-T4 kuphela e-levothyroxine.
I-Natural Desiccated Thyroid Ne-Levothyroxine
Inkinga yemvelo yemvelo, ne-levothyroxine iphikisana amashumi eminyaka. Naphezu kokusetshenziswa kwekhulu leminyaka, emva kokusungulwa kwe-levothyroxine, odokotela babevame ukuphikisana nokusetshenziswa kwezidakamizwa zemvelo ye-thyroid, bethi akukho zifundo ezibonisa ukuthi ziphephile noma ziphumelele.
Kubalandeli be-thyroid ekhishwe imvelo, kwakunezindaba ezibalulekile ezigulini ze -roid eziphuma eMhlanganweni Wonyaka Wonyaka we-Endocrine, owaba ngoJuni ka-2013 eSan Francisco. Ngokusho kwesethulo esenziwe ngu-Thanh D. Hoang, INGABE, abasebenzi be-endocrinologist ye-Walter Reed National Medical Center Centre eBethesda, MD, izidakamizwa zemvelo ezikhethiwe zemvelo zikhona ezinye izindlela zokusebenzisa ukwelashwa kwe-hormone ye-thyroid nge-levothyroxine.
Kulolu cwaningo, uDkt. Hoang wenza ucwaningo oluhlelekile, oluphindwe kabili, oluphambene nezimpumputhe ukuze luqhathanise ukusebenza kwe-thyroid versus levothyroxine njengokwelashwa kwe-hypothyroidism.
Ucwaningo lwaluhlola iziguli ezingama-70, eziphakathi kweminyaka engama-18 kuya ku-65, futhi bonke babe ne-hypothyroidism eyinhloko. Iziguli zazinikezwa ngezikhathi eqenjini elithatha izidakamizwa zemvelo noma i-levothyroxine yemvelo, isamba samasonto angu-16. Lezi zifundo zaziyimpumputhe, okusho ukuthi iziguli azizi ukuthi yimiphi imithi emibili ayitholayo.
Ekupheleni kwesifundo, iziguli zabuzwa ukuthi yiziphi izidakamizwa abazenzayo. Ngokuthakazelisayo, cishe ingxenye yesiqhema-ikakhulukazi, amaphesenti angu-49-akhuluma ngemithi yokwelashwa yemvelo ehlotshisiwe, uma kuqhathaniswa namaphesenti angu-19 abakhetha i-levothyroxine.
Cishe amaphesenti angu-33 weziguli azange acacise okuthandayo.
Ngesithakazelo esikhethekile: UDkt. Hoang uphinde wabika ukuthi iziguli ezithatha isifo semvelo ekhishwe ngokwemvelo zalahlekelwa cishe amakhilogremu amathathu ngesikhathi sokutadisha, uma kuqhathaniswa neziguli ezithatha i-levothyroxine, engazange ilahlekelwe yisisindo.
UDkt. Hoang utshele i- Endocrine Namuhla :
Asizange sithole umehluko emilinganisweni ye-neurocognitive emkhatsini wezokwelapha ezimbili ... Manje sisazi ukuthi okukodwa kwansuku zonke kukhishwe ukukhishwa kwekhanda kuyindlela ephephile yokuphulukisa iziguli ezine-hypothyroidism ezingenelisekile ngelashwa levothyroxine. Kuyinto yokuzikhethela ukuthi bazame, futhi futhi kukhonjiswe kungabangela ukulahleka kwesisindo esimaphakathi kulezi ziguli.
> Umthombo:
> Hoang TD, et al. "Ukucaciswa kwesifo se-thyroid kuqhathaniswa ne-levothyroxine ekwelapheni i-hypothyroidism: ukutadisha okungahleliwe, okubili okuyimpumputhe, okuyimpumputhe." J Clin Endocrinol Metab. 2013 Meyi; 98 (5): 1982-90. doi: 10.1210 / jc.2012-4107. Epub 2013 Mar 28.