I-testosterone yokwelashwa esikhundleni samadoda isetshenziselwa ngezizathu eziningana, ngokuvamile ezivame ukutholakala kwe-testosterone. Izimpawu zokungaqiniseki kwe-testosterone kuhlangene namazinga aphansi e-testosterone angabonisa isidingo sohlelo lwe-testosterone le-substitution le-substitution. Lokhu kungathinta amadoda asevile eminyakeni engu-20, ama-30, ama-40 nangaphezulu. Izimpawu ze-testosterone ephansi zihlanganisa ubuthakathaka, ukukhathala, ukucindezeleka, ukushayela ucansi oluphansi, ukungasebenzi kahle kwe-erectile, nokungasebenzi.
Nokho, lezi zinkinga zingabangelwa amazinga aphansi e-testosterone noma ngezinye izimo zezokwelapha
Ngezinye izikhathi, izingane kanye nentsha ezithatha ama-hormone okuvimbela ukukhulelwa njengengxenye yokubuyiswa kobulili nazo zinikezwa i-testosterone ukukhuthaza ukuvuthwa ngokocansi.
Ukwelashwa kwama-hormone e-Testosterone kungasiza emadodeni athile, kodwa futhi kuhlotshaniswa nezigubhu futhi ungase ubone ngisho nokukhangisa kumacala okukhangisa kwethelevishini kulabo abaye bahlukunyezwa ngenkathi bethatha i-testosterone.
Ngakho-ke, yini okudingeka ukwazi mayelana ne-testosterone ne-strokes ukuze uthole ukwelashwa okudingayo futhi uhlale uphephile?
Testosterone
Ama-hormone yi-steroids eyinkimbinkimbi eyenziwa ngumzimba. Ukukhiqizwa kwe-testosterone yomuntu kanye namazinga adingekayo we-testosterone ahlukahluka phakathi neminyaka, njengoba kunjalo nezinga lakhe le-testosterone. Ukukhiqizwa komzimba kwemvelo yamahomoni aphilayo, kufaka phakathi i-testosterone, ingahle iwele ngenxa yezizathu eziningana, kuhlanganise nokuguga, ukugula kanye nemithi.
Ukushintshwa kwe-hormone ezingenalutho kungahle kube nomthelela wezinto eziphilayo eziyinkimbinkimbi - ngokuyisisekelo kuphakamisa amazinga e-hormone yomzimba kodwa futhi kuguqula izinqubo zomzimba ezijwayelekile, ezingakhuphula noma zinciphise ukukhiqizwa kwe-hormone ejwayelekile yomzimba.
I-testosterone ingaba nemiphumela emibi kakhulu kwi-Stroke Risk.
Ucwaningo oluningi lwezocwaningo lwesayensi phakathi neminyaka luhlolisise ukufaka esikhundleni se-testosterone nobuhlobo bayo nokushaya.
Ukwandisa Ingozi Yokushaywa Isisu
I-athikili yakamuva eyanyatheliswa kuyi-Journal of the American Medical Association ibike imiphumela yocwaningo olukhulu lwabalandeli be-Veterans Affairs olubandakanya amadoda angaphezu kuka-8000. Amadoda alesi sifundo sokucwaninga abathola isifo se-testosterone abhekana nesilinganiso esibi kakhulu sokulimala unyaka owodwa, iminyaka emibili neminyaka emithathu emva kokuqala kocwaningo uma kuqhathaniswa nezilawuli ezingazange zithole ukwelashwa kwe-testosterone.
I-testosterone ingakhuphula ukucindezeleka kwegazi futhi ingakhuphula ingozi yokwakheka kwegazi, okubili kokubili okuyaziwa ukuthi ibangela isifo.
Ukunciphisa Ingozi Ye-Stroke
Njengoba kunikezwe ukufundwa kocwaningi lwe-Veterans Affairs, esinye isihloko esanda kwakamuva sanyatheliswa eMayo Clinic Proceedings, kubukeza idatha evela emininingwaneni emikhulu yemibiko ehlolwa ubuchopho be-testosterone ngokuphathelene nokushaywa yisifo. Abalobi be-Mayo Clinic Proceedings athi iningi lezinhlolovo zocwaningo lisho umphumela ozuzisayo we-testosterone ezinesifo senhliziyo, okuyinto ebangela imbangela yokushaya isifo.
Yini Okufanele Uyenze?
Amakhambi okuthengisa amathikithi e-testosterone kanye namathengisi okukhangisa ukukhangisa kwamadoda ahlukunyezwe ngenkathi ethatha u-testosterone ukwelashwa kubonakala ephikisana.
Isayensi ngokwayo ingabonakala ingavumelani ngokuphathelene nezingozi nezinzuzo ze-testosterone therapy. Ngalokhu konke okuphikisanayo, yini isiguli okufanele senze?
Ukwelashwa kwe-Testosterone akuyona into okumele ibhekwe ngayo-kuyadinga imithi futhi kufanele ilawulwe ngaphansi kokuqondiswa udokotela. Izimpawu zokuntuleka kwe-testosterone zingase zibe amaflegi obomvu okubonisa izinkinga ezinkulu zezokwelapha. Odokotela bakho bazohlola ngokucophelela izimpawu zakho, ukuhlola kwakho ngokomzimba, namazinga akho e-hormone ngaphambi kokuchaza noma yiluphi uhlobo lwezokwelapha ze-hormone.
Zombili amazinga aphansi kakhulu e-testosterone namazinga aphezulu kakhulu e-testosterone ahlotshaniswa nezingozi eziningi zezempilo, kuhlanganise nesifo sohlangothi.
Ukulungiswa kwamazinga aphansi we-testosterone kunconywa kwamanye amadoda. Kodwa, ngokuvamile, ukwelashwa kwe-hormonal kufanele kulungiswe ngokuhamba kwesikhathi ngakho kubalulekile ukulandelana nodokotela wakho uma uqala ukuthatha ukwelashwa okufaka esikhundleni se-testosterone ngoba umthamo wakho ungadinga ukuhlaziywa njalo futhi mhlawumbe uguquliwe.
Idatha ye-testosterone yokwelashwa kabusha kanye neengozi yokushaywa yisifo ngokuphikisanayo, i-FDA iyaqiniseka ukuthi kunengozi yokuthi, maduzane, izinkampani eziqondisa izidakamizwa zenza imishanguzo emikhiqizweni yazo ye-testosterone ukuze zibonise ukuthi ingozi enkulu ye-heart attack futhi uhlangothi. Izinguquko zokubhaliwe zisathuthukiswa futhi azikakenziwa - kodwa zisendleleni.
Ukuhlukunyezwa kwe-Testosterone
Amanye ama-hormone substitution, njenge-testosterone ne-erythropoietin, angakwazi ukuhlukunyezwa futhi angabangela imiphumela emibi uma asetshenziselwa noma ehlukunyezwa uma engekho isidingo sempilo.
> Imithombo:
> Association of the testosterone therapy nokushona, infarction myocardial, kanye nesifo emadodeni aphansi amazinga testosterone, Vigen R, O'Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Ukubonwa G, Wierman ME, Plomondon ME, Rumsfeld JS, Ho PM, JAMA, Novemba 2013
> Ukwelashwa kwe-Testosterone kanye nengozi yemvelo: ukuqhubekela phambili nokuphikisana, uMorgentaler A, Miner MM, Caliber M, Guay AT, Khera M, AM Traish, Mayo Clinic Proceedings, February 2015