Ukuxhuma Phakathi Kwama-Amyloid Angiopathy and Stroke
Isimo okuthiwa i-amyloid angiopathy ngokuvamile ihlotshaniswa nesifo sohlangothi. I-Amyloid angiopathy yi-accumulation of fragments ezingxenyeni zegazi. Ngokuvamile, ukuba khona kwama-amyloid ebuchosheni kuhlotshaniswa nesifo se-Alzheimer, isifo sika-Parkinson nezinhlobo eziningana zokucindezeleka komqondo.
Kodwa-ke, i-amyloid buildup ebuchosheni nayo ingathinta imithwalo yegazi, okwenza ibe buthakathaka futhi kungenzeka ukuthi iphuluke.
Lokhu kubangela ukuphuma kwegazi ebuchosheni, okuvame ukubhekwa ngokuthi yisifo esibuhlungu noma isisu se-intracerebral hemorrhage.
Isibonakaliso
Izimpawu ze-angiopathy yama-amyloid ziyahlukahluka kuye ngokuthi yiziphi izitsha zegazi eziphuma igazi nokuthi zingakanani izitsha zegazi ezibuthakathaka ezigeleza. Uma kunesilinganiso esincane sokugaya, kungenzeka kube khona izimpawu.
Uma iziqephu zegazi eziphindaphindiwe zenzeka, izimpawu zingase ziqale ukubonakala. Kwezinye izimo, izimpawu zingacacile, kubangele ukulahlekelwa kwememori noma ukulahleka okuncane ekusebenzeni kobuchopho, njengombono onzima. Uma kunendawo enkulu yokuphuma kwegazi, lokhu kungabangela izimpawu ezinkulu zezinzwa ezihlanganisa i-hemiparesis, i-hemiplegia, ukulahlekelwa yocwaningo, nokuhlukunyezwa.
Izingozi Zezingozi
Izinto eziyingozi zokuthuthukisa i-amyloid angiopathy aziqondi ngokuphelele umphakathi wezokwelapha ngalesi sikhathi. Into ecacile yengozi ebonakalayo ibudala, njengoba ama-amyloid deposits atholakala kakhulu kubantu abadala kunama-55 kunabantu abasha.
Kubukeka sengathi kunezinhlobo zokuzalwa ezingenalo i-amyloid angiopathy, kodwa abantu bangakwazi ukuhlakulela i-amyloid angiopathy ngaphandle komlando womndeni wesimo.
Izimbangela
Ama-deposit Amyloid angase aqoqe ngaphakathi kwezindonga zegazi emqondweni. Lokhu kubizwa ngokuthi i-amyloid angiopathy.
Ukuqoqwa kwe-amyloid kungabangela ukuba imithwalo yegazi ihlasele ngokuhamba kwesikhathi, kuze kube yilapho ekugcineni iphule futhi iphule.
I-Amyloid nayo ihlotshaniswa nokuvuvukala, okuyinto indlela yomzimba yokubhekana nanoma yikuphi ukulimala noma ukutheleleka. Ukuvuvukala, ikakhulukazi ukuvuvukala okungadingekile noma ngokweqile, kuhlotshaniswa nesifo.
Ngokuvamile, ukuphuma kwamanzi okubangelwa ukungafihleki kwe-amyloid kuyinto encane kakhulu, okuthinta imithwalo encane yegazi. Izindawo ezincane zokugaya zibizwa ngokuthi i-petechial hemorrhages, futhi zibukeka ngendlela ebonakalayo kwi-Brain CT noma Brain MRI.
Esinye sezimbonakaliso ze-intrarebral hemorrhage (ukuphuma kwegazi ebuchosheni) obangelwa i-amyloid angiopathy, ukuthi kwenzeka njalo ezindaweni eziseduze nobuchopho, ekusakazeni okubizwa ngokuthi "i-lobar."
I-Amyloid angiopathy ingase iholele nasezindaweni ezinkulu zokuphuma kwegazi ebuchosheni, okungaba yingozi yokuphila.
Ukuxilongwa
Indlela enokwethenjelwa kakhulu esetshenziselwa ukuxilonga i-amyloid angiopathy iyinhlangano ye-biopsy yobuchopho, okuyinto engeyona inqubo ewusizo. I-biopsy yobuchopho yindlela yokuhlinza eyenza ingozi yokuphuma kanye / noma ukutheleleka. Ngakho-ke, i-biopsies ayenziwanga ngaphandle uma idingeka ngempela.
Udokotela wakho angasebenzisa ifomu le-MRI ebizwa ngokuthi "i-gradient echo" (GRE) ukuthola ezinye izinkomba ezingasiza ukucacisa ukuthi ngabe unayo ingozi ye-amyloid.
Lokhu kuhlolwa okuphumelelayo okuthola ukuphuma kwegazi ebuchosheni. I-GRE ingabona izindawo ezinkulu noma ezincane zokuphuma kwegazi ezenzeka amahora noma iminyaka ngaphambi kokuhlolwa. Ukubukeka kobuciko be-amyloid angiopathy ku-GRE ngokuvamile kubizwa ngokuthi "i-cortical cerebral microbleeding."
Ukwelapha
Uma kwenzeka ukuphuma kwegazi ebuchosheni, ukwelashwa kwe-intracerebral hemorrhage ngenxa ye-angiopathy yama-amyloid akufani neze nokwelashwa kwegazi lokungenwa kwe-intracerebral ngenxa yanoma yimuphi omunye umphumela.
Okokuqala, uma ukuphuma kwegazi kubangela ukunyuka kwengcindezi ye-intrarebral (ICP), kusukela ekuvupheni noma emthonjeni omkhulu, ithimba lakho lokunakekelwa kwesisu lingadinga ukwenza ukuhlinzwa okuphuthumayo noma ukusebenzisa ezinye izinyathelo zokunciphisa ingcindezi.
kusuka ku-swellimg Ithimba lakho lezokwelapha lingakunika futhi imishanguzo yokuvimbela imithi ukuze kuvikelwe ukugwinya, okungase kubangelwe ukuphuma kwegazi ebuchosheni.
Izwi elivela
Ngesikhathi samanje, kuncane okungenziwa ukuguqula inqubo ye-amyloid protein deposition. Uma uthola ukuthi unalesi sifo, kufanele ugcine ukucindezela kwegazi evamile futhi ugweme igazi elincane, njenge-aspirin noma i-plavix, ngoba lokhu kungandisa ingozi yokuphuma echosheni.
> Imithombo:
> Imiphumela ye-Neuropsychological of Cerebral Amyloid Angiopathy, Schrag M, Kirshner H, Curr Neurol Neurosci Rep. 2016 Aug; 16 (8): 76