Umdlavuza webele we-medullary uhlukile kanjani kunezinye izifo zomdlavuza webele?
I-Medullary carcinoma yesifuba ifomu elingavamile lomdlavuza webele. Luhlobo lwe- ductal carcinoma (i-IDC) eliyingozi futhi lithatha igama kusuka kumbala walo, oseduze nombala wezicubu zobuchopho, noma i-medulla. Iqala emathangeni akho obisi, enezinhlayiya ezinkulu zomdlavuza ezibukeka zihluke kakhulu kumaseli enempilo.
I-Medullary carcinoma akuyona into ejwayelekile yokuxilongwa.
I-Medullary carcinoma ilandisa amaphesenti amathathu kuphela kuya ku-5 amaphesenti azo zonke izifo zomdlavuza webele. Kungaba nzima ukuhlukanisa nomdlavuza we-ductal carcinoma futhi kunezinye ukwelapha ezinomunye kodwa hhayi zonke izici ze-medullary carcinoma. Ngenxa yalokhu kudlulela, odokotela ngezinye izikhathi baphatha i-medullary carcinoma ngokufutheka, mhlawumbe, kunokuba kudingeke, banikeze ukubikezela okuhle. Kuvame kakhulu kubantu besifazane ekupheleni kweminyaka engu-40 nangama-50s okuqala.
Ukubukeka
Amangqamuzana e-Medullary carcinoma avame ukwenza umngcele ocacile phakathi kwe-tumor kanye nezicubu ezinempilo eduze kwazo - ayingxenye encane kunamanye amangqamuzana omdlavuza webele. Ngaphansi kwe-microscope, amangqamuzana amancane futhi ayabonakali futhi ahlukumezeka, kodwa athambekele ekusebenziseni ubuhlungu njengoba bebukeka.
Kuningi amangqamuzana omzimba omzimba (njengama-lymphocytes) emaphethelweni alawo mzimba, ekhombisa ukuthi amasosha omzimba asebenza ukulwa nesisu.
Uma umdlavuza webele unomzimba we-medullary carcinoma kodwa awuhambisani nazo zonke izindlela, ungase uzwe isifo sakho esibizwa ngokuthi "i-atypical medullary carcinoma." Lezi zomshukela ezinama-atypical zivame ukuphathwa njengezinye izifo zomdlavuza, ngamanye amazwi, ngokuhlukunyezwa okukhulu.
Izimpawu Nezibonakaliso
I-Medullary carcinoma yesifuba angeke ihlale izwa njengengcosana, kodwa kunalokho, njengendawo epholile, isiponti sezincuba zesifuba.
Kungase kubhalwe kuqala njengobuhlungu, ubomvu, noma ukuvuvukala esifubeni sakho. Njengoba amangqamuzana e-medullary carcinoma enkulu futhi ejwayele ukuhlala ndawonye futhi akhulise endaweni eyodwa, isisu singase sizizwe kunesisindo esimnandi, njenge- cyst yebele . Lesi yisinye sezizathu ukuthi kubaluleke kakhulu ukuba naso sonke isifuba esifubeni sakho sihlolwe, noma ngabe sizwa njenge-cyst elula.
Uvivinyo Lokuthola Ukuxilongwa
Amagciwane ebelethwe ngama-Medullary awabonanga njalo emthonjeni futhi avame ukutholwa kuqala uma othile ezwa inhlama. I- ultrasound yebele ingenziwa futhi. Indlela yodwa yokuhlukanisa i-medullary carcinoma evela kwezinye izinhlobo zomdlavuza webele nge-biopsy. Isampula yama-tissue ngokuvamile ithathwe yi- biopsy evulekile yokuhlinzeka noma yokuphefumula.
Ukwelapha
Iningi le-medullary carcinomas lincane futhi lingaphathwa kalula ngokuhlinzwa. Akunamathuba amaningi kunamanye amagciwane ebeletha ekusakazeni kuma-lymph nodes, kanti odokotela abathile babheka ukuthi ukuhlinzeka yedwa ukuthi kube ukwelashwa okwanele kulezi zicubu (eziningi zazo zingaphansi kwamasentimitha angu-1 ngobukhulu.) Ukwelashwa kungafaka:
- Ukuhlinzwa : Kuhlinzekwa iningi labantu abanalolu hlobo lomdlavuza wesifuba futhi kungaba lumpectomy noma i- mastectomy , kuye ngokuthi indawo ye-tumor kanye nezintandokazi zomuntu siqu.
- I-Chemotherapy : Njengoba iningi lalezi zicubu zimbalwa futhi zingavamile ukusabalala kuma-lymph nodes, i-chemotherapy ngokuvamile idinga kuphela ukuthi izicubu zikhulu kunama-intshi ngobukhulu. Lokho kusho ukuthi eziningi zalezi zinambuzane ziyaba nezici - zezinye izinhlobo zomdlavuza webele, ngakho-ke zingase ziphathwe kabi.
- Ukwelashwa kwezidakamizwa : Futhi, ukwelapha imishanguzo kusetshenziswa kaningi kunezinye izinhlobo zesifo somdlavuza webele, kodwa singasetshenziswa ezimweni ezihlukile.
- Ukwelashwa kwamahomoni : Ukwelashwa kwamahomoni nakho kusetshenziselwa kancane kakhulu nge-medullary carcinoma, njengoba eziningi zalezi zicubu ziyi-hormone receptor engalungile. Kwesinye isifundo, ama-68% alawa amathumba ayengalungile ama-estrogen receptors kanti amaphesenti angu-86 ayilungele i-progesterone receptors.
- I-Herceptin isetshenziswa ngokungavamile ngalolu hlobo lomdlavuza njengoba iningi lalezi zicubu ziyi-HER2 engalungile. Kwesinye isifundo okungaphezu kwamaphesenti angu-80 wezicubu kwakungenalo i-HER2 receptors.
Isibikezelo
I-Medullary carcinoma ijwayele ukuba nama-high-grade avela amangqamuzana asebenza ngendlela ehamba kancane. Akunamathuba okusabalalisa ama-lymph nodes kunezinye izifo zomdlavuza webele futhi jikelele unesibikezelo esihle kakhulu. Esinye isifundo esikhulu, isilinganiso sokusinda esiphezulu eminyakeni emibili sasingu-98.2%. Izinga lokuphindaphinda ngaleli libuye liphansi kakhulu uma kuqhathaniswa nezinye izinhlobo zomdlavuza webele.
Imithombo:
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Lim, S., Park, S., Park, H., Hur, M., O, S., no-Y. Suh. Umsebenzi wokubikezela we-Adjuvant Chemotherapy ku-Node-Negative (NO), i-Triple-Negative (TN), i-Medullary Breast Cancer (MBC) kubantu baseKorea. PLos One . 2015. 10 (11): e0140208.
Shokouh, T., Eztollah, A., noP. Barand. Ukusebenzisana phakathi kwe-Ki67, i-HER2 / neu, i-p53, i-ER, ne-PR Status kanye ne-Associations yabo ne-Tumor Grade kanye nokubandakanya i-Lymph Node ku-Breast Carcinoma Subtypes: Ukubuyela emuva-Isifundo sokuHlola se-Observational. Imithi . 2015. 94 (3): e1359.