Kuhlangene, i-pannus ichazwa njengezicubu ezingavamile ezingenalutho (ezibizwa nangokuthi i- synovium noma ibhande lehlangene) elihlanganisa i- articular cartilage , uhlobo lwe-cartilage etholakalayo kumalungu. Njengoba i-synovium igxila futhi ikhula, i-joint ngokugcwele igcwalisa i-synovium futhi i-synovium engavamile ihambela yonqenqemeni ye-articular, ekugcineni ikhiqize izimo.
Ku-arthritis ye-rheumatoid, ukuvuthwa ngokuvamile kuqala emkhawulweni wokujoyina. Njengoba i-pannus iqhubekela phambili, ingahlasela ithambo namasongo , futhi ibhubhise izakhiwo ezizungezile, njenge-capsule ne-tendon.
Ukuqhathanisa i-Pannus ku-Osteoarthritis ne-Rheumatoid Arthritis
Akuyona into eyaziwa kakhulu ngokuziphatha kwe-pannus ku- osteoarthritis uma kuqhathaniswa ne-pannus ku- arthritis ye-rheumatoid . Abacwaningi benza isifundo ngenjongo yokuqhathanisa i-osteoarthritis pannus ne-arthritis ye-arthritis pannus in vitro (emkhatsini wemibandela) ngo-2008. Imiphumela eyashicilelwe eRheumatology yeziMtholampilo nokuHlola ithola ukufana phakathi kwe-osteoarthritis ne-rheumatoid arthritis pannus - kodwa kungani i-osteoarthritis pannus ihlasela isifo ebusweni kodwa akubangeli ukukhushulwa komzimba okuvame ukubonakala ku-arthritis ye-rheumatoid.
Esicwaningweni, izicubu ze-pannus kanye ne-synovial zitholakala ezigulini ezingu-5 ze-osteoarthritis neziguli ezi-5 zesifo se-rheumatoid ngesikhathi se-arthroplasty (ukushintshaniswa okuhlangene), bese zikhuliswe futhi zifundiswa.
I-pannus yachazwa abalobi bokutadisha ngokuthi "izicubu ezincane ezinamandla okugunula ezinobuningi bomhlaba". Zonke izifundo zezifundo zazinama-panic ne-fibrous pannus. Ukwanda kwe-synovial kungena ekuvuvukala, futhi ukwehla kwamaprotheni e-extracellular kubhekwe kumasampula amathishu atholakele.
Ukwanda kwe-Chondrocyte kwakungaphansi kwe-osteoarthritis cartilage kune-rheumatoid arthritis cartilage. Izicubu ze-osteoarthritis synovial zazinamazinga aphansi ama-proteoglycans kunama-rheumatoid arthritis synovial tissue. Uhlobo lwe-II lwe-collagen lwaluphansi kakhulu e-osteoarthritis cartilage kune-rheumatoid arthritis cartilage. Amazinga aphakeme kakhulu we-interleukin-1-beta ayehlotshaniswa ne-arthritis panthus ye-rheumatoid uma kuqhathaniswa ne-osteoarthritis pannus. Amazinga aphezulu we-TNF-alpha, i-IL8, ne-TIMP-1 ayehlotshaniswa kokubili i-osteoarthritis ne-rheumatoid arthritis pannus.
Okubalulekile
Kwaqedelwa ukuthi i-rthmayid arthritis ne-osteoarthritis pannus inemibono efanayo ye- cytokine enama-pro-inflammatory and anti-inflammatory. Kungani i-osteoarthritis pannus engabangeli izifo ezincane ezifana ne-rheumatoid arthritis isaziwa.
Ngaphandle kwe-pannus yamajoyina okwenzeka ku-osteoarthritis ne-rheumatoid arthritis, i-pannus ingenza kwezinye izindawo, njenge-over cornea, noma ku-valve inhliziyo valve. Njengoba i-pannus ikhula, ingase ibonakale sengathi i-tumor.
Imithombo:
I-Arthritis Ye-Rheumatoid: Ukuhlola ku-MRI Izici ku-System Musculoskeletal. Hong Kong Journal of Radiology. Munk et al. 2002; 5: 63-68.
I-osteoarthritis kanye ne-rheumatoid arthritis pannus inezici ezifanayo zokufanisa umzimba nokuphendula kwe-cytokine e-pro-inflammatory. I-Furuzawa-Carballeda J. et al. I-Rheumatology yezokwelapha kanye nokuhlola. 2008 Jul-Aug; 26 (4): 554-60. http://www.ncbi.nlm.nih.gov/pubmed/18799084
RA Pathophysiology. Ulwazi lwe-Arthritis. UJohn Hopkins. September 24, 2013.
http://www.hopkinsarthritis.org/arthritis-info/rheumatoid-arthritis/ra-pathophysiology-2/