Imikhiqizo ye-Vitamin A, kuhlanganise ne-retinol ne-Retin-A, ibizwe ngokuthi "izinga legolide" lokunakekelwa kwekhanda lokulwa nokuguga, kusiza isikhumba sakho sibonakale sincane futhi sibhebhelele. Kodwa lezi zithako zazithuthukiswa kanjani, futhi ziphumelela kangakanani ekuphatheni imibimbi, nasesikhumba esikhulile?
I-vitamin ebalulekile
Ukubaluleka kwevithamini A empilweni yethu kwafunyanwa ekuqaleni kwekhulu lama-20, lapho kutholakala indima yayo ekusebenzeni kombungu.
Kusukela ngaleso sikhathi, kuye kwafunyanwa kuba umdlali omkhulu hhayi nje ekukhiqizeni, kodwa futhi nombono, ukukhula, nokuhlukaniswa kwamangqamuzana kanye nokwanda. Ngenxa yokuthi kusiza ukukhiqizwa kwamangqamuzana amhlophe egazi, i-vitamin A iyadingeka ukuze kutholakale amasosha omzimba aphilile.
I-Vitamin A nayo yaziwa nangokuthi i-retinol, futhi izakhi zayo (kungakhathaliseki ukuthi zendalo noma ezakhiwe) zibizwa ngokuthi i-retinoids. Ngenxa yokuthi le vithamini ayikwazi ukuhlanganiswa ngomzimba, kufanele idliwe ekudleni - noma ngemithombo yezilwane, njengezikhupha zamaqanda, izinhlanzi, isibindi, nenyama, noma imithombo yemifino, njengezithelo ezimnandi nemifino emnyama ehlanganisa amazambane, amathanga, kanye utamatisi.
Usizo Lesikhumba Esikhulile
Isimo samanje se-Vitamin A njengesikhumba sokuguga esimangalisa sabuyela emuva kuma-1980 ngenkathi abacwaningi bethola ukuthi i-tretinoin etholakalayo (igama lomkhiqizo Retin-A) lisize ekukhuliseni ukukhiqizwa kwe-collagen kumagundane lapho kusetshenziselwa ukukhishwa kwesikhumba esithombeni , okungukuthi, isikhumba ngaphambi kwesikhathi eside ukuvezwa kokukhanya kwe-ultraviolet kusuka elangeni.
Ukuhambisana nalokhu kutholakala kwakuboniswa odokotela bebeka i-tretinoin ye-acne ukuthi iziguli zinesikhumba esisheshayo, ezinemibala embalwa. Kamuva uTretinoin wathola ukuphazamisa ama-enzyme asebenza ukudiliza i-collagen enqenqemeni yesikhumba futhi ukukhuthaza ukwakhiwa kwe-collagen entsha.
Kusukela ngaleso sikhathi, i-retinoids iye yaziwa ngokuthi "izinga legolide" lemikhiqizo yokuguga ngokweqile, ngokusho kwabalobi be-2003 yokuhlola ucwaningo eshicilelwe kuyi- Journal of Drugs in Dermatology .
Okuhle, Okubi Nebizo likaTretinoin
I-Tretinoin ezigxilweni ezihlukahlukene (ngokuvamile 0.01 - 0.1%) iye yafundwa ngokucophelela kokubili uphenyo lwesikhashana kanye nesikhathi eside, ngokubheka ukubuyekezwa kuka-2006 kwe- Clinical Interventions in Aging .
Ngenkathi inguqulo ephuzwayo ye-vitamin A esetshenziswa ekwelapheni kwe-acne, i-isotretinoin (igama lomkhiqizo u- Accutane ), nayo yasiza iziguli ezinezikhumba ezishisayo , zino-pinker , isotretinoin ngomlomo ithwala ingozi enkulu yokukhubazeka kokuzalwa. Nakuba i-tretinoin yama-topical engakaze iboniswe ezincwadini zokubeka usongo olufanayo, ezinye imibiko yecala liphakamise ukukhubazeka kokuzalwa phakathi kwabesifazane basebenzisa i-tretinoin esikhumbeni sabo ku-trimester yokuqala yokukhulelwa. Ngakho-ke abesifazane baxwayiswa ngokusebenzisa umkhiqizo ngenkathi bekhulelwe.
Abasebenzisi bokukhalaza abakhulu banalo i-tretinoin umphumela ohlangothini manje owaziwa ngokuthi i-retinoid dermatitis, efaka ubomvu, ukucasula nokukala okungase kuthuthuke ngokushesha noma phakathi kwamasonto ambalwa okuqala ukwelashwa. Odokotela bavame ukuthi bathuthukise ukuqala kwe-concentration (0.01 - 0.025%), futhi bayisebenzise ngamanani amancane njalo ngosuku.
Ukushintsha kusuka i-gel kuya kwisikhilimu se-cream emollient nakho kunganciphisa ukucasula isikhumba. Uma ukubekezelelana sekukwakhiwe, ukusebenzisa i-tretinoin nsuku zonke kanye / noma ukusebenzisa i-dose egxilile okungaphezulu kungaphatha kakhulu.
Iphinda iphendule imifanekiso
I-Tretinoin ibonakala iphumelela kakhulu ekunciphiseni imigqa emihle ebusweni kanye nemibimbi, ukunciphisa isikhumba esibucayi, isikhumba esifakwe ngezithombe, nokuthuthukisa ukuguqulwa okungalingani. Kungathatha izinyanga ezimbalwa ukuze le miphumela emihle ibonakale, futhi imiphumela ixhomekeke emthamo, okusho ukuthi ukugxila okunamandla kuletha imiphumela ephawulekayo ngokushesha. Isibonelo, ngenkathi ukuhlushwa okungu-0.05% kunganciphisa kakhulu imiphumela ye-photohotel, ngakho-ke ingxenye yalokho (noma i-0.025%), kodwa lokhu okulandelayo kuzodinga isikhathi eside.
Izingqinamba ezingaphansi kuka-0.01% azibonwanga ukusiza isikhumba se-photoaged.
Ezinye izici ezithinta ukuthi imisebenzi ye-tretinoin ihlanganisa kanjani izakhi zofuzo, ikhwalithi ngayinye yesikhumba, kanye nesilinganiso se-photodamage.
Amanye ama-Vitamin A
Amandla kaTretinoin okubangela ukucasula isikhumba kanye nokuhlelwa kwawo njengesidakamizwa (okudinga umshwalense) uye wakhangela ucwaningo oluningi ngamakhiqizi wezitho zomzimba nezamakhemikhali ezinhlanganweni ezinamandla, ezincane kakhulu. Phakathi kwazo kukhona i-retinol, i-retinaldehyde, ne-retinyl palmitate. I-Retinol iguqulwa ibe yi-tretinoin esikhumbeni, nakuba ukuhlushwa okubangelwa yi-1/1000 kuphela ye-tretinoin (futhi ngenxa yalokho iyathukuthelisa kancane) uma isetshenziswa phezulu.
Amagugu amaningi e-vitamin A asetshenziselwa imakethe ye-anti-aging skincare emakethe ayimayelana namafomu - ngaphandle kocwaningo olushicilelwe ezincwadini zemfundo - ngakho-ke kunzima ukubukeza.
Ngaphansi
Imikhiqizo ye-Vitamin A efana ne-tretinoin ye-topical iye yaboniswa ukunciphisa imibimbi, ubomvu, nokuguqulwa okungalingani, nakuba (okungavamile) kungabangela ubomvu nokucasula esikhathini esifushane. Uma ufuna ukuzama ukuguqula ukushiya izithombe, thintana nomhlinzeki wakho wezempilo noma ubone i-dermatologist ye-odokotela. Imikhiqizo engaphezu kwamakhompiyutha aqukethe i-vitamin A etholakalayo ingase isebenze nokuguga isikhumba, nakuba imiphumela yabo ivame ukuba yinto encane kakhulu, futhi iyanzima ukuqinisekisa.
Imithombo:
Izinguquko eziguga esikhumbeni. I-US National Institutes of Health Medline Information Sheet Sheet. http://www.nlm.nih.gov/medlineplus/ency/article/004014.htm
Kockaert M, Neumann M. Systemic, kanye nezidakamizwa zezokwelapha zekhanda eliguga. J Izidakamizwa Dermatol. 2003 Aug; 2 (4): 435-41.
U-Siddharth Mukherjee, Usuku luka-Abhijit, uVandana Patravale, uHans Christian Korting, u-Alexander Roeder noGünther Weindl. I-Retinoids ekunakekeleni ukuguga kwesilonda: ukubuka konke okusebenzayo ekusebenzeni komzimba nokuphepha. Ukuguga kwe-Clin Interv. 2006 uDisemba; 1 (4): 327-348
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/
I-Vitamin A. I-National Institutes of Health Medline Information Sheets Sheet. http://www.nlm.nih.gov/medlineplus/druginfo/natural/964.html