Ukuvama, Ukuvimbela, Nezibonakaliso zale Nsima Eceleni YeRituxan
Ukusabela kwe-allergen kuya eRituxan, eyaziwa nangokuthi MabThera noma i-Rituximab , yindlela ejwayelekile yomphumela walesi sidakamizwa esetshenziselwa ukwelapha i-lymphoma nezinye izifo. Ziyini izibonakaliso zokuphendula okweqile futhi kanjani ukuphendula okuphethwe?
Sibutsetelo
I-Rituxan yi- antioclonal anti-antibody , okusho ukuthi ihlose i-molecule ethile (i-CD-20) emasethini amamasosha omzimba-amangqamuzana egazi omhlophe angumthombo we-lymphomas, kodwa lokho kubalulekile nakwezinye izifo eziningi zokuzivikela, njenge-rheumatoid i-arthritis.
I-Rituximab iyindlela yokwelapha ephumelelayo kwi-non-Hodgkin's lymphoma (NHL) futhi iboniswe ukuthuthukisa ukusinda kwezinye zezinhlobo ezivamile ze-NHL kubandakanya ukusabalalisa okukhulu kwe-B-cell lymphoma kanye ne- follicular lymphoma .
I-Rituximab iqukethe amaprotheni amancane avela emathisini egundane. Ngenxa yalesi sizathu, i-rituximab iyaziwa ngokuthi "i-anti-chimeric antibody," okusho ukuthi yenziwa kusuka ezingxenyeni ezivela ezinhlobonhlobo ezimbili ezihlukene. Yize lokhu kubalulekile ukuba izidakamizwa zisebenze, imizimba yethu ihlose ukuqaphela amarekhodi angaphandle kanye nabahlaseli abangahle futhi baqale ukuphendula ngomzimba ngokumelene nabo. Ukusabela okweqile ku-rituximab ngokuvamile ukusabela kumaprotheni wegundane kulesi sidakamizwa.
Ngaphambi kokuba i-rituximab ingeniswe, cishe uzokwelapha ngemithi eyanciphisa amathuba okuba uzothola ukuphendula. Lokhu kuhlanganisa iTylenol (i-acetaminophen) ne-Benadryl (diphenhydramine) kanye neminye imithi ye-steroid.
Njengoba i-diphenhydramine ingakwenza ulale, ngokuvamile kunconywa ukuthi omunye umuntu akushayele ekhaya ngemuva kokukhipha kwakho.
Izimpawu Nezibonakaliso
Izibonakaliso ezivamile ze-rituximab yokungezwani komzimba yizi:
- I-Fever ne-chills - lezi yizona ezithinta kakhulu futhi zenzeka kubantu abaningi
- I-nausea
- Itching
- Rash
- Ukuthukuthela okukhulu noma ukuchelela emakhaleni
- Ukuvuvukala kwezandla, izinyawo noma ubuso
- Nciphisa ukucindezeleka kwegazi kanye nesizungu
- I-spasm yomphimbo, ofana ne-asthma
- Izinwele
Lezi zindlela ezithathelwanayo zivame ukuqhubeka zingakapheli imizuzu engama-30 kuya kumaminithi angu-2 ukuqala ukumnika ukuphathwa kwezidakamizwa futhi kungenzeka ukuthi kwenzeke nge-infusion yokuqala ( cishe amaphesenti angu-80 weziguli ezithintekayo ) futhi ahlale engezansi imijikelezo elandelanayo.
Ngokuvamile, ukusabela okunzima kungenzeka, kubandakanya:
- Izinkinga eziphefumulayo ezinzima
- Ukuhlaselwa kwenhliziyo
- Ukuwa okujulile ekucindezeni kwegazi nokushaqeka.
Ukwelapha
Uma unomthelela naphezu kokunikezwa imithi yangaphambi kokubeletha, into yokuqala umhlengikazi noma udokotela akwenzayo iyancipha noma imise ukumnika. Ukuze uthole ukuphendula okuncane, yilokho okungase kudingeke. Izidakamizwa eziningana zingasetshenziswa ukunciphisa noma ukumisa ukusabela. Lokhu kuhlanganisa i-acetaminophen, i-antiallergics, i-IV saline noma izidakamizwa zokwandisa ukucindezelwa kwegazi kanye ne-steroids. Kuzo zonke iziguli, ukusabela kungalawulwa ngokushesha ngalezi zinyathelo. Ukuphendula okukhulu, izinyathelo zokunakekelwa ezinamandla zingase zifaneleke kakhulu-ngezinyathelo zokugcina nokuqapha ukucindezeleka kwegazi nokuphefumula. Nakuba ukubulawa kwabantu kuye kwabikwa kusukela ekungeneni kwe-infusion, kuyinto engavamile kakhulu.
Ukuvimbela
Izinyathelo ezimbalwa zingavimbela noma zinciphise ukusabela okwe-allergen nge-rituximab:
- Ukulungiswa. Njengoba kuphawuliwe ngenhla, cishe uzothatha imithi ye-antihistamine kanye ne-steroid ngaphambi kokukhipha.
- Ukuqala ukumnika kancane kancane. Lokhu kubaluleke kakhulu ekukhusheni kokuqala uma ukusabela kuyinto evamile kakhulu. Ama-infusions ajwayele ukuqala kancane futhi izinga lokumnika likhuphuka uma kungabikho ukusabela okwenzekayo.
- Ukuyeka imishanguzo yengcindezi yegazi ngaphambi kokuncipha. Njengoba ukuwa kwegazi kungenziwa ngesikhathi sokuphendula, odokotela ngezinye izikhathi banxusa iziguli ukuba ziyeke ukusebenzisa imishanguzo yengcindezi yegazi ngaphambi kokukhipha. Kufanele wenze lokhu kuphela ngaphansi kweziqondiso ezithile ezivela kudokotela wakho, noma kunjalo.
Labo abaye basabela ngendlela emnene noma elinganisiwe nge-rituximab banganikezwa umuthi kancane futhi badinga ukuthatha zonke izinyathelo zokunakekelwa zokwelapha ezalandela. Labo abanesisindo esinzima kaningi abangeke baphathwe lesi sidakamizwa.
Imithombo:
LaCasce, A., Castells, M., Burstein, M., noJe Meyerhardt. Ukusabela ukumnika ukumelana namaphilisi omzimba we-monoclonal asetshenziselwa ukwelapha umdlavuza. Kusesikhathini. Kubuyekezwe 01/08/16. http://www.uptodate.com/contents/infusion-reactions-to-therapeutic-monoclonal-antibodies-used-for-cancer-therapy