Izindleko Zokuthi "I-FDA ivunyelwe"
Imithi yomdlavuza omusha wesandulela ngculazi iya emakethe ngokungajwayelekile ngoba izifundo ezigunyazwe yi-FDA zibiza amakhulu ezigidi zamaRandi. I-FDA idinga ukuthi lezi zifundo zihlukanise ngezikhathi ngamadoda emaqenjini amabili okuqhathanisa. Iqembu elilodwa lithola imithi emisha ehlolwe. Elinye iqembu lithola inkohliso engasebenzi, ebizwa ngokuthi i-placebo. Ucabanga ukuthi lolu cwaningo lwenziwa ngendlela eyamukelekayo, i-FDA izovuma imithi emisha ukusetshenziselwa ukuhweba, kuphela uma amadoda athola imithi emisha ephulukisa labo abaphathwa nge-placebo ngamanki ecacisiwe ngaphandle kokudla ngokweqile.
Ukuthola ukuthi amakhulu amavolontiya azimisele ukuhlanganyela kulezi zinhlobo zezifundo kunzima. La madoda ayazi ukuthi kukhona ithuba lokuthola indawo engenzi kahle. Ngubani ofuna ukuthatha ithuba lokuthola iphilisi le-sugar uma ebhekene nesifo esisongela ukuphila? Noma kunjalo, ngemva kokusebenzisa zonke izinketho zokwelapha ezitholakalayo ngokuvamile, ziba nesifiso futhi zibhalisele isifundo, zithemba ukuba nethamsanhla futhi zithole iMcCoy yangempela.
Lezi zifundo zigijima iminyaka ngoba seziqedile kuphela lapho iningi labahlanganyeli bezocwaninga befile ngomdlavuza oqhubekayo. Ukuze uthole inani elanele labahlanganyeli, izinkampani eziqaphayo ezihlela nokuqhuba lezi zifundo zidinga ubudlelwane bokusebenzisana nezikhungo eziyikhulu noma ngaphezulu zokufunda. Izindleko eziphakeme zalezi zifundo kulula ukuyiqonda uma ucabangela imfuneko yokugcina ithrekhi yazo zonke lezi ziguli ezihlukene, ezindaweni eziningi kangaka, esikhathini esengeziwe.
Ukuhlinzeka ngomuthi owodwa ovunyelwe yi-FDA yokwelapha umdlavuza wesibeletho oye wakwazi ukunqoba zonke lezi zinselele. Ukuhlinzeka kunendlela ehlukile yokusebenza eyenza ngokuqinisa isimiso somzimba sokuzivikela. I-Dendreon, umkhiqizi, inqubo enelungelo lobunikazi elivuna amangqamuzana omzimba egazini nge-plasmapheresis, inqubo yehora lesithathu efana ne-dialysis.
Amaseli avunyiwe abese esetjenziswa ebhokisithri ekhethekile futhi axutshwe nezinto ukuthuthukisa ukuhlukumeza kwabo ngokumelene nomdlavuza. Amangqamuzana afanayo abuye aphinde afakwe kwisiguli esifanayo.
Ukunikeza isikhalazo esiyinhloko yisimiso esincane semiphumela emibi. Kodwa-ke, ukwelashwa, okungaxhomeki ku-chemotherapy, kuguquguquke kangangokuthi ngemva kokutadisha kokuqala i-FDA yaphoqelela inkampani ukuba iphinde iphinde isetshenziswe ukuze iqinisekise ukuthi ukwelashwa ngempela kwandisa impilo ngenxa yokungabaza. Kwaphinde kwaba yilapho isifundo sesibili sibonisa ukuthi amadoda angaphatheki kahle angama-30% amathuba okuphila iminyaka emithathu emva kokwelashwa kwabo uma kuqhathaniswa namadoda athola indawo ye-placebo. Ekugcineni, i-FDA yavuma imiphumela futhi yavuma. Njengoba kungacatshangwa, ukubambezeleka, ukungalokothi kubhekise izindleko ezengeziwe zokuphindaphinda isifundo, kwanda kakhulu izindleko zokuthuthukiswa kweMpahla.
I-Jevtana, uhlobo olukhuthaziwe lwe-chemotherapy, lenye i-agent ukuthi i-FDA ivunyiwe ngokusekelwe ekutadisheni okuqhubekayo okuqhubekayo. Nokho, esikhundleni se-placebo, i-Jevtana yayiqhathaniswa ne-chemotherapy esekhulile okuthiwa i-Mitoxantrone eyanciphisa ubuhlungu kodwa engenzi isikhathi sokusinda. Amadoda angama-755 ahlinzekwe ngokungahleliwe ekwelapheni ngeJevtana noma iMitoxantrone.
Ukusinda kwamadoda athola iJvtana kwakungu-30% kangcono kunamadoda aphathwe noMitoxantrone.
Indaba yokuthi uSanofi-Aventis uletha kanjani i-Jevtana, uhlobo olusha lwe-chemotherapy, ukudayiswa ngokumangalisayo ngokucabangela ukuthi inkampani yezokwelapha, yathatha ingozi enkulu ngoba ihlolwe i-Jevtana emadodeni asebevele ephikisana ne-Taxotere. (I-Taxotere ibhekwa njenge-"standard" chemotherapy yomdlavuza we-prostate.) Le ndlela yathatha abachwepheshe bezezimboni ngenxa yamlando, amadoda angamelana ne-Taxotere kulindeleke ukuba aphendule kabi kakhulu nakwezinye izifo zamakhemikhali. Naphezu kwalabo abathintekayo, uJevtana wafakazelwa ukuthuthukisa impilo, ngisho naseqenjini eliphikisana neziguli.
Izindleko zama-antiticancer agents zanamuhla kulula ukuyiqonda lapho kucatshangwa iminyaka yokutadisha okudinga ukusetshenziswa kwamakhulu ezinkulungwane zamaRandi. I-Jevtana ne-Provide yizindaba zokuphumelela. Ngeshwa, uma sicabangela izindleko eziphezulu zale mithi kumele sibuye sibheke ezindlebeni ezengeziwe zezidakamizwa eziningi ezihlolwe ngezilingo ezingenalutho kodwa zahluleka ukukhombisa ukuthuthukiswa kokusinda.
Manje ukuthi i-Jevtana ne-Provenge ziye zafakazelwa ukuthi zisiza amadoda ukuba aphile isikhathi eside, izifundo eziqhubekayo ziyaqhubeka ukuze kutholakale ukuthi lezi zici ezibaluleke kakhulu ze-anticancer zingasetshenziswa kanjani ngendlela engcono kakhulu. Ngokuyinhloko, ukuphumelela kwabo kungase kuthuthukiswe ngokuhlanganisa nabo neminye imithi noma ngezinhlobo ezahlukene zemisebe.