I-Avodart ne-Proscar yi-FDA-evunyelwe ukuphatha imiphumela emibi ye-urinary kusuka ekukhuliseni i-prostate . Igama elijwayelekile le-Avodart liyi-dutasteride; igama elijwayelekile le-Proscar liyi-finasteride. Le mithi, kodwa inomthelela omkhulu wokusebenza ngaphandle nje kokuthuthukisa umsebenzi we-urinary. Zisebenza ngokuvimbela uhlobo lwe- testosterone olubizwa ngokuthi i-dihydrotestosterone (i-DHT) eligxila ku-prostate, eliyishukumisela ukuba likhule futhi likhiqize isilwane.
Lapho i-DHT ivimbele i-prostate gland, yehlisa ukugeleza kwamanzi.
Kunemiphumela emibi engaba khona. Ukukhiqizwa kwe- Semen kuvame ukunciphisa. Ngezinye izikhathi amadoda abika ukunciphisa kwe-libido kanye ne-potency. Futhi, ukwandiswa kwebele kungenzeka. Ngokuvamile, lemiphumela emibi izogqoka noma iyanciphisa uma nje umuthi umiswa lapho kuqala uphawu lwenkinga. Ngaphandle kwezinzuzo zomchamo, kukhona uhlu olude kakhulu lwezinye izinzuzo ezikhona.
I-Avodart noma i-Proscar inga:
- I-PSA engaphansi futhi unciphise ingozi yokuthola ukuthi unesifo somdlavuza we-prostate
- Thuthukisa izinga lokutholakala komdlavuza we-prostate high-grade kumadoda asebenza nge-biopsy
- Umdlavuza we-Gleason 6 (umdlavuza wezinga eliphansi) ukulungisa noma ukucindezelwa
- Ukusebenzisana nezinye izidakamizwa ezisetshenziselwa ukwelapha umdlavuza we-prostate njengeCasodex noma uLupron
- Siza ukugcina amadoda ekubhekeni okusebenzayo futhi anciphise ingozi yokuhlinzwa okudingekayo noma imisebe
- Nciphisa umdwebo wephethini wesilisa
- Ukunciphisa i-orgasm emadodeni ane-ejaculation ngaphambi kwesikhathi
I-Anti-Cancer Effects
Ekuhlolisweni okungahleliwe kuqhathaniswa neProscar ne-placebo, amadoda angu-10 000 aphethwe i-prostate biopsy ngemva kweminyaka eyisikhombisa yokwelapha. Amadoda aphathwe nge-Proscar atholakala ukuthi unomdlavuza olinganiselwa ku-25% kancane uma kuqhathaniswa namadoda aphathwe nge-placebo.
Kodwa-ke, umdlandla wokusetshenziswa kwePscar ukuvimbela umdlavuza wancipha ngoba isifundo esifanayo sabika ukuthi 1% yenyuka izinga lokuhlola umdlavuza we-prostate eliphezulu.
Ochwepheshe ngaleso sikhathi babecabanga ukuthi i-Proscar yayikhulisa izinga lokuthola kunokuba ibangele izifo eziphezulu. Kodwa-ke, uPeter Scardino MD, urologist ovelele e-Memorial Sloan Kettering wanyathelisa umbono wokuthi iPrascar ingabangela umdlavuza ophezulu, ukuphakamisa zonke izinhlobo zokucindezeleka nokugqugquzela i-FDA ukubeka isixwayiso. Konke lokhu kwesaba ekugcineni kwaxoshwa ku-Agasti 15 th , 2013, i-New England Journal of Medicine eyayingabonisi ukwanda komdlavuza wesifo sofuba emadodeni abaphathwa nge-Proscar uma kuqhathaniswa namadoda aphathwa nge-placebo emva kweminyaka engu-18 yokubona.
Kusukela ku-Avodart no-Proscar basebenze ngendlela efanayo, okuningi okwaziwa ngePrascar nakho kungashiwo ngo-Avodart. Bobabili ama-agent avimbela u-5- alpha-reductase (5-AR), i-enzyme eguqula i-testosterone ibe yi-DHT. Kukhona inzuzo yokufunda i-Avodart ngaphezu kwe-Proscar ngoba u-Avodart uvimba i-enzyme engu-5-AR ngokucophelela. Nokho, akukho ukuhlolwa komtholampilo okwenziwayo ukuqhathanisa lawa ma-agent amabili ikhanda.
Njengoba i-Proscar ne-Avodart ephansi i-PSA ngamaphesenti angama-50, umbuzo uvela, "Ingabe baxosha amandla e-PSA ukukhombisa ukuqhubeka komdlavuza?" Ngokufushane, impendulo ayikho. Le mithi ayimiseli i-PSA ekukhuleni kwamadoda anomdlavuza oqhubekayo. Nokho, i-PSA isetha kabusha ezingeni eliphansi le-50% ngemuva kokuqala i-Proscar noma i-Avodart. Ngokwesilinganiso, indoda ene-PSA ka-6.0 ngaphambi kokuqala i-Proscar izokwehla ku-3.0 ezinyangeni ezimbalwa. Ngokulandelayo, uma i-PSA iphakama njalo ngaphezu kwe-3.0, ukuqhubekela phambili komdlavuza kuyadingeka ukuba kujabuliswe njengesizathu esithile.
U-Proscar no-Avodart bavame ukuba nomthelela omubi futhi kukhona ambalwa uma kukhona ukusebenzisana neminye imithi.
Uma kwenzeka imiphumela emibi, zivame ukuguqulwa. I-Proscar ne-Avodart zikulungele ngoba zingathathwa noma nini nosuku, noma ngaphandle kokudla. I-Finasteride, i-generic ye-Proscar iyatholakala futhi ingabizi kakhulu. Izindleko ezihle kanye nephrofayili yomphumela wesikhashana yenza kube lula ukucubungula iziguli ezine-cancer yomdlavuza abafuna ukulawula i-PSA ngenkathi begcina izinga elihle lokuphila ngezindleko eziphansi.