Izinselelo ezintsha zokucwaninga ngocwaningo lwe-methotrexate engozini
I-Methotrexate iyisidakamizwa esiyisigciwane sokuzivikela esisetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza kanye nezinkinga eziningi zokuzibulala , kuhlanganise ne-psoriasis enamandla ne- rheumatoid arthritis (RA) .
Kuyaphawuleka ukuthi ucwaningo oluthile luye lwasikisela ukuthi i-methotrexate, eqinisweni, ingandisa ukwanda komdlavuza kubantu abane-RA, kuhlanganise ne-melanoma, i-leukemia, i-myeloma, umdlavuza wamaphaphu, ne-lymphoma.
Eminyakeni eyishumi kusukela kuqala kwalezi zifundo kushicilelwe, kube khona ingxabano eqhubekayo mayelana nokuthi ingozi ingase ibe yiphi ngempela. Ingabe i-methotrexate iphephile ukuyisebenzisa, noma ingabe kunezici ezingabeka abanye abantu engozini enkulu kunabanye?
Okushiwo Usesho Lwasekuseni
Ngo-2008, isifundo se-Australia sibuyekeze imlando yezokwelapha yabesifazane abangu-309 namadoda angu-150 anama-RA abesebenzise i-methotrexate ngaphambi kuka-1986 futhi eqhathanisa nesilinganiso somdlavuza kuleso sigaba sabantu abaningi.
Ngokusho kocwaningo, abantu abane-RA abaye babhekwa ne-methotrexate babenengozi enkulu engamaphesenti angu-50 okuthuthukisa ukwelapha kwanoma yiluphi uhlobo. Ngaphezu kwalokho, babe nokwanda okuphindwe kabili engozini ye- non-Hodgkin lymphoma (NHL) kanye nokukhula kathathu emdlalweni wamaphaphu kanye nengozi ye- melanoma .
Kulaba bantu abangu-459 abafakiwe kulolu cwaningo, ama-malignancies angu-87 atholakale.
Ngenkathi lolu cwaningo lusekela ucwaningo lwangaphambili engozini yomdlavuza we-NHL nomdlavuza kubantu abanobuchopho obusekelwe emettretrexate, abaningi emphakathini wesayense babengaqondanga ukuthi ngabe i-methotrexate yayiyizifo noma isifo ngokwayo.
Lokhu kwakuyiqiniso ikakhulukazi kwe-melanoma kusukela ukuklanywa kocwaningo akuvumelanga ukufakwa kwezici ezinobungozi njengokudala noma ukukhanya kwelanga.
Lokho Ucwaningo Lwakamuva Lusitshela
Ngo-2017, ososayensi eYunivesithi yaseGenhenburg eSweden baqhuba ucwaningo oluthile ukuze babheke ngokuqondile ingozi ye-melanoma ezigulini eziphathwe nge-methotrexate ezine-RA.
Ukusebenzisa izibalo ezivela kwiBhodi likaZwelonke lezeMpilo kanye neZenhlalakahle, abaphenyi baphinde bahlaziya amafayela ekhophi kwanoma ubani oneminyaka engaphezu kwengu-18 obanikezwe lesi sidakamizwa kusukela ngo-2005 kuya ku-2014.
Ngokwesifundo esashicilelwe, abantu abane-RA abaye baphathwa nge-methotrexate kuphela babe nengozi enkulu engamaphesenti angu-10 e-melanoma kunabantu abaningi. Ngaphezu kwalokho, iningi lamacala labandakanya abesifazane abaye baqala ukwelashwa ngemva kweminyaka engama-70. Ngakho-ke, ubudala bangase badlale indima enkulu kunazo zonke ezinikezwe ukuthi abantu abaneminyaka engaphezu kuka-65.
Abanye abacwaningi, baqala ukuphenya inhlangano ephakathi kwe-RA nomdlavuza kungakhathaliseki ukuthi i-methotrexate. Olunye uphenyo oluqhutshwa yi-University of Maryland School of Medicine lubukeze idatha kusuka ezifundweni eziyisikhombisa eziphakeme ezisemtholampilo ezishicilelwe phakathi kuka-2008 no-2014.
Inani lezincwadi eziyisishiyagalolunye lihlangabezane nenqubo yokufaka. Abayisikhombisa baphenye ingozi yomdlavuza kubantu abane-RA; abayisishiyagalombili babheka i-lymphoma, i-melanoma, i-lung, i-colorectal, ne-cancer yomabele; okuyisikhombisa kugxile kumdlavuza wesi-prostate; futhi uphenyo olwenziwe emdlalweni wesibeletho somlomo wesibeletho.
Lapho sekuqedile ukubuyekezwa, abacwaningi babike ukuthi ingozi enkulu yomdlavuza yayingamaphesenti angu-10 kuphela kunabantu abaningi.
Ngaphezu kwalokho, ingozi yomdlavuza webele, wesibeletho, i-coloredal, ne-prostate yayincane ngokuqhathaniswa.
Okufanayo akuzange kubambelele kwamanye amagciwane. Phakathi kokuthola:
- Izinga le-lymphoma laliphakeme kakhulu, ikakhulukazi isifo se-Hodgkin esinezinkinga ezingu-12 ezinobungozi.
- Umdlavuza we-Lung ngokuvamile wabonisa ukwanda okuphindwe kabili.
- I-Melanoma yayinyuke kancane kwamaphesenti angu-25
Akumangalisi ukuthi lawa angamakhansela agcizelelwe ikakhulukazi esifundweni sase-Australia.
Lokhu akusikisela ukuthi i-methotrexate ayidlala nhlobo engozini yomdlavuza. Kusitshela nje ukuthi ukunakekelwa okungaphezulu kudinga ukuthathwa ukuqinisekisa ukuthi umdlavuza ukuhlolwa kubantu abane-RA noma i-methotrexate inqunywe noma cha.
> Imithombo:
> Buchbinder, R .; I-Barber, M .; UHeuzenroeder, uL. et al. "Ukukhubazeka kwe-melanoma nezinye izidakamizwa phakathi kweziguli ze-rheumatoid arthritis eziphathwe nge-methotrexate." I-Arthritis Rheum . 2008; 59 (6): 794-9. I-DOI: 10.1002 / ubuciko.23716.
> Polesie, S .; Gillstedt, M .; INdodana, H. et al. "Ukwelashwa kwe-Methotrexate kanye nobungozi be-melanoma engcolile enomzimba: isifundo esilandelayo sokubhalisa-esekelwe isifundo seqembu." I-Brit J Derma. 2017; 176 (6); 1492-1499. I-DOI: 10.1111 / bjd.15170.
> Simon, T .; Thompson, A .; Gandhi, K. et al. "Ukukhubazeka kweziguli ezikhulile ezine-arthritis ye-rheumatoid: a .meta-analysis." . I-Arthritis Res Ther. 2015; 17 (1): 212. I-DOI: 10.1186 / s13075-015-0728-9.