I-Methotrexate ivame ukushiwo ukuphatha i- arthritis ye-rheumatoid nezinye izimo ze-rheumatic. I-Methotrexate ibhekwa njengesidakamizwa sokulwa nesifo (DMARD) eshintsha isifo . Isidakamizwa sinciphisa ubuhlungu nokuvuvukala okuhambisana nesifo samathambo, kunciphisa ukuqhubeka kwesifo, futhi kusiza ukuvimbela umonakalo owodwa. Uma ucabangela ukusebenza kahle nokuphepha, ingumjovo we-methotrexate kangcono kune-methotrexate yomlomo?
Ukutholakala
I-methotrexate yomlomo itholakala kumaphilisile angu-2.5 mg. Isilinganiso esivamile sokuqala umthamo kubantu abadala abane-arthritis ye-rheumatoid i-7.5 kuya ku-10 mg (amaphilisi amathathu kuya kwangu-4) athathwe kanye kanye ngesonto. Uma kunesidingo, umthamo kungenzeka kancane kancane ukhuphuke ube ngu-20 kuya ku-25 mg ngesonto. Udokotela wakho uzokwenzela isilinganiso esilungile kuwe.
Umjovo we-Methotrexate unikezwa ngaphansi kwesikhumba (ngaphansi kwesigqila). Kufika njengo-25 mg nge-1 milliliter noma ububanzi bamakhilogremu. Nakulokhu, udokotela wakho uzobeka umthamo okufanele usebenzise. Ezinganeni ezine-arthritis ye-rheumatoid, i-dose isekelwe isisindo somntwana.
Iyiphi i-Form of Methotrexate Ekhethiwe?
Umjovo we-Methotrexate uthathwa njengento elula kakhulu iziguli eziningi uma kuqhathaniswa ne-methotrexate yomlomo. Ukuthenga izilingana nokuzibopha ngenaliti isonto ngalinye kungaba yingozi. Abanye abantu empeleni kukhona inaliti-phobic. Ngakho-ke, kungani ukhathazeka lapho ungaphala amaphilisi ambalwa?
Kuthiwani uma kube khona umehluko emkhatsini we-methotrexate injection kanye ne-methotrexate yomlomo ngokusebenza kahle nangengozi yemiphumela emibi?
Ngokomphumela wesilingo sokuqala emtholampilo ukuhlola ngokucophelela ukuphathwa kahle kwe-methotrexate kuziguli ezine-arthritis esebenzayo, okushicilelwe ku-January 2008 i-Arthritis & Rheumatism, umjovo we-methotrexate (obizwa nangokuthi i-methotrexate engaphansi) iphumelela kakhulu kunomlomo ukuphathwa kwe-methotrexate ngesilinganiso esifanayo, ngaphandle kokwanda kwemiphumela emibi.
Kwakukhona abathintekayo abangu-384 esifundweni seviki ezingu-24 ababesebenzisa umjovo we-methotrexate ngezikhathi ezithile noma i-methotrexate yomlomo. Abahlanganyeli bokutadisha, bathi banomsebenzi ophezulu wezokwelapha ekuqaleni kokucwaninga, bathola umjovo we-methotrexate wamasonto ama-15 wamasonto onke kanye ne-placebo yomlomo noma i-methotrexate yomlomo we-15 mg ngesonto kanye nomjovo we-placebo.
Kusuka kwedatha yokucwaninga, abacwaningi baphetha ngokuthi imithi ye-methotrexate, esebenzisa isilinganiso esingaba ngu-15 mg / isonto isikhathi esingenani amasonto angu-24 (kufaka phakathi ukukhuphuka kwemithi), iphakeme kakhulu ekuqalisweni kwe-methotrexate ngomzila womlomo. Emasontweni angama-24, iphesenti yeziguli ezine- ACR20 impendulo ziphakeme kakhulu eqenjini elithola injection methotrexate (78%) kuneqembu elithola methotrexate yomlomo (70%).
I-Methotrexate i-Slow-Acting
Nge-methotrexate ukusetshenziswa, ukuthuthukiswa kwezibonakaliso ze-arthritis ye-rheumatoid noma umsebenzi wesifo kuvame ukutholakala emavikini amathathu kuya ku-6. Kungathatha amasonto angu-12 yokwelapha nge methotrexate ukufeza inzuzo ephelele.
Okuqhamuka uma udla imishanguzo
Iziguli eziningi ze-arthritis ze-rheumatoid azibi nemiphumela emibi ngenkathi zithatha methotrexate. Ezinye iziguli zithola imiphumela emincane emibi ethuthukisa ngokuhamba kwesikhathi.
Umphumela ovamile kakhulu we-methotrexate yi-nausea.
Ezinye imiphumela emibi ingabandakanya ukuhlolwa kokusebenza okungavamile kwesibindi , izilonda zomlomo , ukuqhuma, isifo sohudo, ukulahleka kwezinwele , ukuzwela kwelanga , nokungajwayelekile kwezibalo zegazi. Kukhona izinkinga zamaphaphu futhi.
Imithombo:
I-Methotrexate (i-Rheumatrex, i-Trexall, i-Otrexup, i-Rasuvo). I-American College of Rheumatology. UMichael Cannon, MD. Mashi 2015.
Ukuqhathaniswa nokusebenza kahle komtholampilo kanye nokuphepha kokulawulwa komzimba okungezansi komlomo we-methotrexate kuziguli ezine-arthritis esebenzayo. I-Braun et al. I-Arthritis & Rheumatism Volume 58, Issue 1, Amakhasi 73-81. Disemba 28, 2007.