Ucwaningo Olukhulu lwe-Scale lunikeza isixhumanisi
Sekuyisikhathi esithile, ochwepheshe baye bacabanga ukuthi izifo ezitholakale zisencane-njenge-diarrhea noma i-cold common-zingadlala indima ekuthuthukiseni isifo se-celiac. Kodwa, ucwaningo lwamuva oluqhutshwa eJalimane lungase lunikeze ifolda engaphezulu yekhonkrithi kulesi simangalo.
Isifo se-Celiac yisifo somzimba sokuzivikela omzimba lapho umuntu engakwazi ukudla khona gluten ngoba izovutha nokulimaza intombazane encane.
Izimpawu zivame kakhulu ezinganeni futhi zifaka ukubhula, isifo sohudo esingavamile, ubuhlungu besisu, nokuhlanza. Ukulandela ukudla okungekho gluten, noma kunjalo, ngokuvamile kuzokwehlisa noma yiziphi izinkinga ezihlobene nesimo.
Isixhumanisi Sokuqala Kwesifo-Celiac Izifo
Abacwaningi bahlaziya amarekhodi angama-295,420 amantombazane azalwa phakathi kuka-2005 no-2007 eBavaria, eJalimane. Baqale babona inani lezifo ezenzeke phakathi nonyaka wokuqala wokuphila owadinga ukunakekelwa kwezokwelapha. Bese babalwa ingozi ehambisanayo yokuthola ukuthi unesifo se-celiac ebuntwaneni. Izingane zalandelwa phakathi kokuzalwa kanye nobudala obuphakathi kweminyaka eyi-8.5.
Sekuphelele, izingane ezingu-853 zathuthuka isifo se-celiac eminyakeni engama-5 ubudala. Kulaba bantwana, abangu-820 (amaphesenti angu-95.5) athuthukise isifo se-celiac emva konyaka wokuqala wokuphila. Abacwaningi bathola ukuthi amathumbu-nangaphansi kwesifo sokuphefumula-kwandisa ingozi yesifo se-celiac kamuva.
Ngaphezu kwalokho, izifo eziphindaphindiwe zamathumbu zaphakamisa ingozi ngisho nangaphezulu.
Esifundweni esingaphambili esisekelwe kubantu, eshicilelwe kuyi -American Journal of Gastroenterology , abacwaningi bahlola izingane ezingu-72 921 zaseNorway phakathi kokuzalwa kanye neminyaka eyi-8.5. Ngokufanayo nabacwaningi baseJalimane, abacwaningi baseNorway bathola ukuthi kwakukhona ukuxhumana phakathi kwesifo se-celiac kamuva nezifo ezitholakala phakathi kokuzalwa nezinyanga ezingu-18.
Izinkinga ezikhona kanye nokunye okucatshangelwayo
Kuze kube manje, ucwaningo olusekelwe emphakathini lubonise ukuthi ukuxhumana phakathi kokutheleleka kokuqala kanye nesifo se-celiac kamuva sikhona. Umbuzo obaluleke kakhulu ukuthi ukutheleleka kokuqala kususa kanjani isifo se-celiac. Kunezindlela eziningi ezingenzeka ukuthi ukutheleleka kungabangela isifo se-celiac. Nazi izinhloso ezimbili:
- Ama-virus angabangela ukukhiqizwa kwama-protein abulalayo (i-interferons) futhi aholele ekukhululweni kwe-transglutaminase, i-enzyme edlala indima ebalulekile ekuphatheni kwe-gluten ukuze ivuse impendulo yomzimba.
- Ukutheleleka kungakwandisa ukuguqulwa kwamagumbi okugaya kanjalo nokuvumela ukuba i-gluten idlule ekusakazeni-isinyathelo esibalulekile ekuthuthukiseni isifo se-celiac.
Kungenzeka ukuthi izici eziningana-hhayi nje ukutheleleka-zidlala indima ekuthuthukiseni isifo se-celiac. Ngokwesibonelo, kwenye inhlolovo yakamuva, elandelwa izingane ezivela eMelika naseYurophu, abacwaningi bathola ukuthi izinto eziningana zazibandakanya ekuthuthukisweni kwesikhathi kwesifo se-celiac ngaphezu kokutheleleka kokuqala kwamathumbu. Lezi ezinye izici ziyi-genetics, isimo sokugoma i-rotavirus, iminyaka yokusetshenziswa kokuqala kwe-gluten, nokuncelisa.
Ngokuphawulekayo, abacwaningi bathola ukuthi ingozi yesifo se-celiac kamuva yancipha lapho izingane ezazitholakala ezifweni ezithathelwanayo ezifweni zelaliac zathola umuthi wokugoma we-rotavirus futhi zaziswa nge-gluten ngaphambi kwezinyanga eziyisithupha ubudala.
(Umuthi wokugoma we-Rotavirus uvikela i-rotavirus, imbangela enkulu yokuhuda kubantwana nezingane ezincane.)
Izwi elivela
Ukutholakala okucwaninga okukhulu kwesikhulu kuwukusekela ukuthi ukuxhumana okukhona phakathi kokutheleleka kokuqala nesifo se-celiac kukhona-hhayi ukuthi lesi sixhumanisi siyisisusa. Ngamanye amazwi, nakuba ukutheleleka kwasekuseni futhi kamuva izifo ze-celiac ziboshwe, asazi ukuthi ngabe izifo zakuqala zibangelwa yini isifo se-celiac.
Olunye ucwaningo lubonakala ukuthi ukugoma kokuqala kwe-rotavirus kungase kuhlinzeke ngezinzuzo ezithile zokuzivikela ngokumelene nesifo se-celiac. Ngaphezu kwalokho, isingeniso sokuqala sikakolweni sikakolweni noma ezinye izinhlobo ze-gluten nazo zinganciphisa ingozi.
Kuleli phuzu, asikwazi nje okwanele ukwenza ukubikezela. Ucwaningo olungaphezulu luzodinga ukwenziwa.
Khumbula ukuthi i- CDC itusa ukuthi, ngezinyanga eziyisithupha ubudala, zonke izinsana zigonywe nge-rotavirus. Phela, i-rotavirus ingaba yingozi, okuholela ekutheni izikhungo ezingama-60,000 zihlinzekwe esibhedlela e-United States unyaka ngamunye. Okwamanje, kungenzeka ukuthi umuthi wokugoma we-rotavirus ungadlala indima ebalulekile ekuvikeleni ingane esikhathini esizayo isifo se-celiac ingabhekwa njengebhonasi eyengeziwe. Kodwa, ngaphambi kokuletha i-gluten ekudleni komntanakho, khuluma nodokotela wakho-ikakhulukazi uma unomlando womndeni wokungahambisani kwe-gluten.
> Imithombo:
> Beyerlein A, Donnachie E, Ziegler AG. Izifo ekuqaleni kokuphila nokuthuthukiswa kwesifo se-celiac. Am J Epidemiol. 2017.
> I-MedlinePlus. Izifo zeCeliac.
> Kemppainen, KM, et al. Izinto Ezibangela Ingozi Yezifo Zama-Celiac Autoimmunity Ngemuva kokutheleleka Kwesisu Embusweni Wokuqala. I-Gastroenterology Clinic neHepatology 2017; 15: 694-702.
> Mårild, K, et al. Izifo kanye Nengozi Yezifo Ezibucayi Ekubuntwaneni: Isifundo Seqembu Likazwelonke Likahle. Am J Gastroenterol. 2015; 110: 1475-1484;