Igromegranate , eyake ibhekwa njengento exotic, manje iyathandwa kakhulu. Ijomegranate ijusi litholakala cishe kuzo zonke izidlo eNorth America.
Kodwa umbiko wezindaba owashicilelwa kuyi- American Journal of Cardiology umagazini ka-September 1, 2006, ukhombisa ukuthi igromegranate ingaxhumana nemithi ejwayelekile.
Indoda eneminyaka engu-48 yayithatha i-ezetimibe (Zetia®) 10 mg ngosuku kanye ne-rosuvastatin (Crestor®) 5 mg njalo ngosuku ngezinyanga ezingu-17.
Bobabili imithi isetshenziselwa uketshezi oluphakeme.
Waqala ukuphuza ijusi yamapomegranate (200 ml kabili ngesonto) kanye namasonto amathathu kamuva, wamukelwa esiphuthumayo ngezinhlungu zethanga kanye nezinga eliphakeme le-serum creatine kinase (138.030 U / L, evamile <200 U / L). Bobabili yizimpawu ze-rhabdomyolysis, isimo esibucayi esibangela ukuwohloka kwemisipha futhi kungaholela ekuhlulekeni kwezinso.
I-Rosuvastatin yileli qembu lemithi ebizwa ngokuthi i-HMG-CoA reductase inhibitors, noma 'iziqu'. IJupefruit juice yaziwa ukuthi yandisa ingozi ye-myopathy eyenziwe ngu-statin, kodwa kuze kube manje, kwakungekho ulwazi oluncane mayelana nokuthi i-pomegranate ijusi ingase futhi ikhulise ingozi.
Ijomegranate ijusi nesiphuzo se-grapefruit, bobabili bayaziwa ngokuvimbela izinhlelo ze-cytochrome P450 3A4 emathunjini. Ngokuvimbela la ma-enzyme, ama-juice angase akhulise amazinga amaningi wegazi.
Ukubambisana Kwamapulangwe-Ukusetshenziswa Kwezidakamizwa
- I-Antiarrhythmic - i-Amiodarone (iCordarone®), i-disopyramide (i-Norpace®), i-quinidine
- Ama-block blockers e-Calcium - i-Felodipine (i-Plendil®), i-nicardipine (i-Cardene®), i-nifedipine (i-Procardia®), i-nimodipine (i-Nimotop®), i-nisoldipine (i-Sular®)
- Izitatimende - Atorvastatin (Lipitor®), lovastatin (Mevacor®), i-simvastatin (iZocor®)
- Ama-Immunosuppressants - I-Cyclosporine (i-Sandimmune®, i-Neoral®), i-tacrolimus (i-Prograf®)
- Ama-protease inhibitors - i-Saquinavir (i-Fortovase®)
Noma kunjalo, ijusi lamapomegranate lingabuye lihlanganyele nemithi engekho kuleli hlu.
Imithi ezetimibe ne-rosuvastatin ayicatshangwa ukuthi idilizwe yi-cytochrome P450 3A4.
Ngokusekelwe ebufakazini obunganiselwe mayelana nokusebenzisana kwezidakamizwa okungenzeka, kubalulekile ukuthi ukhulume nodokotela wakho uma uthatha imithi futhi ucabangela ukuphuza ijusi legomegranate.
Imithombo:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Imiphumela yejomegranate ijusi kumuntu we-cytochrome p450 3A (i-CYP3A) ne-carbamazepine pharmacokinetics emagatsheni. Ukudakwa kwezidakamizwa nokulahlwa. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Imiphumela engavimbela izithelo zezithelo kwi-CYP3A. Ukudakwa kwezidakamizwa nokulahlwa. 34.4 (2006): 521-3.
I-Sorokin AV, i-Duncan B, iPanetta R, Thompson PD. I-rahabdomyolysis ehambisana nokusetshenziswa kwamagomegranate ijusi. I-American Journal of Cardiology. 98.5 (2006): 705-6.
Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela olayisensi. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.