I-TSH Ingabe Isivivinyo Esiyinhloko sokuthola nokuqapha umsebenzi we-Thyroid
Ukuhumusha amazinga e-TSH akuyona into enembile, ngakho awuyedwa uma uzibuza ukuthi amazinga akho e-thyroid asho ukuthini , futhi ngokuqondile ukuthi amazinga aphakeme aphansi ne-TSH asho ukuthini ukwelashwa.
Ngokwesibonelo, ungase uzibuze ukuthi kungani udokotela wakho efuna ukwehlisa esikhundleni sokuphuza imithi yakho ye-thyroid uma imiphumela yakho ye-TSH iphansi, noma, ngokunye, kungani udokotela wakho ekwandisa imithi yakho ye-thyroid uma i-TSH yakho iphakeme.
Qinisekisa ukuthi, nakuba kungase kubonakale emuva, konke kunengqondo uma ubheka ukukhiqizwa kwe-hormone ye-thyroid.
Izisekelo ze-Thyroid
Ingubo yakho ye- thyroid ikhiqiza i-hormone ye-thyroid. Uma isebenza kahle, i-thyroid yakho iyingxenye ye-loop yempendulo ne-pituitary gland yakho efaka izinyathelo eziningana ezibalulekile:
- Okokuqala, i-pituitary yakho inzwa izinga le-hormone yegciwane ekhishwe egazini.
- I-pituitary yakho ikhulula i-hormone yesithunywa esikhethekile: i-hormone evuselela i-thyroid (TSH). Indima ye-TSH ukugqugquzela i-thyroid ukukhipha i-hormone engaphezulu ye-thyroid.
- Uma i-thyroid yakho, nganoma yisiphi isizathu-ukugula, ukucindezeleka, ukuhlinzwa, noma ukuvinjelwa, isibonelo-akusho noma ayikwazi ukukhiqiza i-hormone ye-thyroid eyanele, i-pituitary yakho ithola amazinga we-hormone ye-thyroid eyancishisiwe futhi ishukumisela ekwenzeni ngokwenza i-TSH ngaphezulu, okuyinto evuselela i-thyroid ukuze wenze i-hormone engaphezulu yegciwane. Lona umzamo we-pituitary wokukhulisa amazinga we-hormone yegciwane bese ubuyisa uhlelo olujwayelekile.
- Uma i-thyroid yakho ingasebenzi ngokweqile futhi ikhiqiza i-hormone ye -roid kakhulu-ngenxa yezifo, noma ukuthatha imithi ephakeme kakhulu yemithi ye- hormone esikhundleni se-thyroid -izinzwa zakho ze-pituitary ukuthi kune-hormone ekhulu kakhulu yegciwane ejikelezayo futhi iphuza noma igweme ukukhiqizwa kwe-TSH. Lokhu kwehla ku-TSH kuwumzamo wokubuyisa ukujikeleza amazinga we-hormone yegciwane kuya evamile.
Ukuhumusha amazinga we-TSH
Uma uqonda lezi zisekelo eziyisisekelo ze -roid, kulula ukuqonda ukuthi i-TSH ephansi ne-TSH ephezulu yembula mayelana nomsebenzi wakho we-thyroid.
Njengoba i-TSH iphakamisa ama-hormone e-thyroid futhi igcina uhlelo ngokulinganisela okujwayelekile:
- I-TSH ephakamisa ikhombisa ukuthi i-thyroid yakho ingasebenzi (hypothyroid) futhi ingenzi umsebenzi wayo wokukhiqiza i-hormone ye-thyroid eyanele. I-TSH eyengeziwe idinga ukuvuselela i-thyroid yakho ukukhiqiza i-hormone engaphezulu ye-thyroid.
- I-TSH ephansi ikhombisa ukuthi i-thyroid yakho iyasebenza ngokweqile (hyperthyroid) futhi ikhiqiza i-hormone ye-thyroid eyedlulele. I-pituitary gland icindezela i-TSH ukuze i-thyroid ingabi nakakhulu.
Ingabe i-TSH iyathembekile?
Ngesikhathi sokuxilongwa, odokotela abaningi basebenzisa uhlolo lwe-TSH ukuze bahlole umsebenzi wakho we-thyroid futhi banqume inkambo yokwelapha efanele.
Kodwa-ke, phawula ukuthi abanye odokotela banomuzwa wokuthi ukuthembela kuphela ku-TSH, ngaphandle kokuhlola futhi amazinga ama-hormone we-thyroid yangempela, njenge-thyroxine yamahhala (T4), angeke akwazi ukuthola izinkinga ze -roid ezicashile.
Ngokwesibonelo, i-T4 yamahhala ngaphezu kwe-TSH iphinde ihlolwe uma udokotela esho ukukhubazeka kwe-thyroid ngenxa yesifo se-pituitary gland noma i-hypothalamus. Ngokufanayo, uma i-TSH iyinto evamile, kodwa umuntu usenayo izimpawu zokuba hyperthyroid noma hypothyroid, i-T4 yamahhala ingahlolwa.
I-TSH nayo ayinakwanele ukuqapha i- hypothyroidism ngesikhathi sokukhulelwa , yingakho i-T4 yamahhala kanye / noma inani le-T4 libuye lihlolwe.
Kuye ngesimo somtholampilo, ezinye izivivinyo ze-thyroid ezingase zihlolwe zihlanganisa i-triiodothyronine (T3), i- T3 ebuyela emuva , kanye nokuhlolwa kwe-antibody.
Ama-Rang Reference Ranges
I-hitch enkulu ekuxhumaniseni i-TSH kuya kwe-hypothyroidism ne-hyperthyroidism ukungahambisani okuqhubekayo emhlabeni wezokwelapha phezu kwebala lokubhekisela le-test TSH.
Amanothi angaphansi kwe-0.4 abhekwa njengobungqina obukhona bokuthi i-hyperthyroidism, kanti amazinga angaphezulu kuka-5.0 ajwayele ukubhekwa njengobufakazi be-hypothyroidism, kodwa ochwepheshe abathile banomuzwa wokuthi lolu hlu lukhulu kakhulu nokuthi kufanele lufinyeleleke ku-0.4 kuya ku-2.5mU / L.
Ukunquma Ukwelashwa Ngokusekelwe ku-TSH
Uma uphathwa nge-hypothyroidism ngezidakamizwa ezithathelisayo ze-hormone, odokotela bazozama ukukufaka emthonjeni "ovamile" we-TSH kusuka ku-0.3 / 0.5 ekupheleni okuphansi, kuya ku-3.0 / 5.0 ekupheleni okuphezulu.
Ngakho-ke, uma usuqalile ukuhlola futhi i-TSH yakho ingena ngaphansi kwejwayelekile (okusho ukuthi i-TSH iyasuswa ngoba ama-hormone wegciwane asevele ephakeme), udokotela wakho angase afune ukunciphisa umthamo wakho we-hormone yegciwane ngoba usuvele u-hyperthyroid . Lokhu kungenxa yokuthi ukucindezelwa ngokweqile kwe-TSH (okusho ukukhiqizwa kwe-hormone ephezulu ye-thyroid) kungandisa ingozi yomuntu we-fibrillation ye-atrial (i-heart arrhythmia) noma i-osteoporosis.
Futhi uma isilingo sakho se-TSH singena ngaphezu kwesijwayelekile, odokotela abathile bazofuna ukwandisa umthamo wakho we-hormone yegciwane, ngoba amazinga angaphezu kwesijwayelekile abhekwa njengama-hypothyroid (angasebenzi).
Izwi elivela
Ngokufingqa, ukuhlolwa kwe-TSH yilaba odokotela abahlolwa ngegazi ngokuyinhloko basebenzisa kokubili ukuxilonga i-hypothyroidism ne-hyperthyroidism nokuqapha ukwelashwa kwe-hormone ye-thyroid (uma kudingeka).
Nakuba izimo zezokwelashwa, njengokukhulelwa noma ezibhedlela, zingadinga ukuthi i-T4 no-T3 zilinganiselwe, ukuqonda umqondo oyisisekelo wokuthi amazinga aphezulu noma aphansi e-TSH asho ukuthini umsebenzi wakho we -roid ngempela inyama yalokho okudingeka ukwazi.
Lokho kusho, uma unemibuzo mayelana nomsebenzi wegazi ohlobene ne-thyroid, qiniseka ukuthi ubuze udokotela wakho.
> Imithombo:
> Bahn, R., Burch, H, Cooper, D, et al. I-Hyperthyroidism nezinye izimbangela ze-Thyrotoxicosis: Iziqondiso Zokuphatha ze-American Thyroid Association ne-American Association of Endocrinologist Clinic. I-Endocrine Practice. I-Vol 17 No. 3 Meyi / Juni 2011.
> Braverman, L, Cooper D. Werner & Ingbar's The Thyroid, 10th Edition. I-WLL / Wolters Kluwer; 2012.
> Garber, J, Cobin, R, Gharib, H, et. al. "Iziqondiso Zomtholampilo Zokusebenza Nge-Hypothyroidism Kubantu Abadala: I-Cosponsored yi-American Association of Endocrinologists Clinic kanye ne-American Thyroid Association." I-Endocrine Practice. I-Vol 18 No. 6 Novemba / Disemba 2012.
> I-Ross DS. (2017). Ukuhlolwa kwelabhulali yomsebenzi we-thyroid. Ku: UpToDate, Cooper DS (Ed), UpToDate, Waltham, MA.