Nakuba kungaboniswa ukuphatha i-polycystic ovary syndrome (i-PCOS), i- metformin imithi ejwayelekile kakhulu ehlinzekwa ukusiza abesifazane abakhubazekile. Ucwaningo olusha olusha luveza ubuhlobo phakathi kokusetshenziswa kwe-metformin yesikhathi eside kanye nokuntuleka kwe-vitamin B12, kodwa abahlinzeki abaningi benakekelo yezempilo abavamile ukuhlola isimo se-B12 kubasebenzisi be-metformin. Ukuntuleka kwevithamini B12 kungabangela ukulimala okungathí sina nokuhlala njalo kwegazi.
Nakhu okumele ukwazi nge-vitamin B12 uma uthatha i-metformin.
Yini i-Metformin?
I-Metformin isebenza njenge- insulin-sensitizer ukunciphisa ukukhiqizwa kwe-glucose futhi ivame ukushiwo abantu abane-type 2 sikashukela ngenxa yalesi sizathu. Amanye amagama we-metformin afaka i-glucophage, i-glucophage XR, i-glumetza, ne-fortamet.
I-Metformin inciphisa i-blood glucose kanye namazinga e-insulini ngezindlela eziningana: Iqeda ukukhiqizwa kwe-glucose yesibindi, ikhulisa ukuzwela kwesibindi sakho, ama-muscle, amafutha, namaseli ku-insulini umzimba wakho okwenzayo, futhi kunciphise ukumuncwa kwama- carbohydrates oyidlayo.
I-Metformin iye yaboniswa ukuthuthukisa i-insulin namazinga we-lipid (i-cholesterol) kwabesifazane abane-PCOS futhi ingasiza ekuthuthukiseni ukuvuthwa.
Ukusetshenziswa kwe-Metformin ne-Vitamin B12
ImiSebenzi yokuLungelwa kwesifo sikashukela IsiFundo (DDPOS) simelela olunye lwezifundo ezinkulu kunazo zonke zokuthola imithi ye-metformin etholakalayo. Ukuhlaziywa okusha kwe-DDPOS eyanyatheliswa kuyi- Journal of Clinical Endocrinology kanye neMetabolism ibheke amazinga e-B12 abantu abane-prediabetes abathatha u-850 mg Metformin kabili ngosuku futhi baqhathanisa nalabo abathwala indawo ye-placebo.
Amazinga e-Vitamin B12 ahlolwe eminyakeni emihlanu nangama-13.
Imiphumela evela ku-DDPOS ibonise ukuthi ukusetshenziswa kwe-metformin yesikhathi eside kwandisa ingozi yamazinga e-vitamin B12. Eminyakeni engu-5, amaphesenti angu-5.2 wabasebenzisi be-metformin babe namazinga aphansi we-serum B12. Eminyakeni engu-13, amaphesenti angu-9.2 wabasebenzisi be-metformin abe namazinga aphansi e-B12. Lapho ukulawula iminyaka yobudala, ubulili, kanye ne-BMI, kwakukhona amaphesenti angu-13 okwandisa ingozi yokuntula kwe-B12 unyaka ngamunye wokusetshenziswa kwe-metformin.
Kukholelwa ukuthi i-metformin ingathinta ukumunwa kwe-vitamin B12 ku-ileum yezinambuzane ezincane. Akukhona kuphela amazinga e-vitamin B12 athintshwe ekutadisheni kwe-DDPOS, kodwa amazinga ka-homocysteine, umaka weengozi zenhliziyo, yanda ngokuhamba kwesikhathi kubasebenzisi be-metformin.
Ezinye izifundo zibonise ukuthi i-metformin ingathinta amazinga ka-vitamin B12 ezincane ezinyangeni ezintathu zokusetshenziswa. Ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta kubheka abantu abane-type 2 yesifo sikashukela nabesifazane abane-PCOS abathatha i-metformin. Imiphumela yabo yathola ukuthi i-metformin ephakeme kakhulu, abantu abangenalutho babe ne-vitamin B12 nokuthi i-metformin inciphise amazinga e-vitamin B12 kokubili (iminyaka engu-3) futhi emfushane (<3 iminyaka) ukusetshenziswa kwesikhathi.
Isilinganiso esiphansi se-metformin kwabesifazane abane-PCOS singama-1,500 mg kuya ku- 2,000 mg nsuku zonke. Abaningi besifazane abane-PCOS bathatha ukulinganisa okuphezulu kwe-metformin ukuze basebenzise isikhathi eside, okwandisa ingozi yabo yokuntula i-vitamin B12.
Ukubaluleka kweVithamini B12
Amavithamini ahlanzekile ngamanzi, i-B12 kubalulekile ekuqhubeni kwegazi, ukusebenza ngokwengqondo, ukuhlanganiswa kwe-DNA, nokubunjwa kwegazi elibomvu. I-Vitamin B12 ngokuyinhloko itholakala kumikhiqizo yezilwane. Labo abalandela ukudla okunama-vegan kumele badle ukudla kwabo nge-vitamin B12. Umthamo wansuku zonke onconywayo we-vitamin B12 kubantu abadala abaningi yi-2.4 mcg.
Izimpawu zokuntula kwe-B12 zihlanganisa izinhlobo ezithile ze-anemia, i-neuropathy (ukulimala kwamantombazane), ukukhathala okungapheli, ukulahlekelwa inkumbulo, ukudideka, ukuguquka kwemizwelo kanye nokuwohloka komqondo.
Ukuntuleka kwevithamini B12 kuyingozi kakhulu, kuthinta isimo sengqondo namandla futhi kungaholela ekuhlinzekeni kwegazi okuhlala unomphela nokungapheli. Ngezinye izikhathi ukuthatha i-multivitamin ene-vitamin B12 isengabangela ukungabi nabasebenzisi base-metformin. Abantu abathatha i-metformin kumele bahlolwe njalo ngonyaka amavithamini B12 kanye nokudla ukudla okufanelekile. Uhlobo lwe-methylcobalamin lwe-vitamin B12 ngesimo sokulinganisa (ngaphansi kolimi) lungcono kakhulu emzimbeni.
Ukutholakala Kwe-Vitamin B12 Kutholakala Kanjani?
Isampula yegazi ingahlola amazinga kavithamini B12. Kuye kwaphakanyiswa ukuthi amareferensi webhu labamazinga ajwayelekile we-B12 asethwe phansi futhi izimpawu zokuntuleka zingabonakala emazingeni angaphansi kuka-400 pg / ml.
Ukuhlola i-methylmalonic acid (i-MMA) isilingo esibucayi esingabonisa ngokunembile isimo se-vitamin B12.
Ngezansi: Uma uthatha i-metformin, cela udokotela wakho ukuthi ahlole amazinga akho e-vitamin B12 ngonyaka bese wengeza ukudla kwakho nge-vitamin B12 ukuvimbela izinkinga zokuntuleka.
Imithombo:
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