I-Provera i-hormone evikela isibeletho futhi ilawula ukuya esikhathini
I-Provera ingahle ibekwe ngezizathu eziningana, ngokuvamile kuvame ukwelapha izikhathi ezinzima noma ukuyeka izikhathi (amenorrhea) ezibangelwa inkinga ye-hormone engaphansi. I-provera (i-medroxyprogesterone) ifomu le- progesterone-i -hormone eyenziwa ngokwemvelo ngemva kokuvuthwa kwegazi (uma iqanda likhishwa kwi-ovary).
Ngaphezu kwalokho, i-Provera ngezinye izikhathi ihlangene ne-estrogen ukuphatha izimpawu ezihlobene nomama (isibonelo, ukukhanya okushisayo) kubesifazane be-postmenopausal abanesibeletho.
Kulesi simo, inhloso kaPravera ukuvimbela ukuqina kwesibindi sokubeletha, okungabangela umdlavuza wesibeletho. I-Provera ingasetshenziswa futhi ekuvivinyweni kwenselele ye-progesterone.
I-Provera ne-Amenorrhea
I-amenorrhea yesibili eyenzeka lapho owesifazane eyeka izikhathi ezijwayelekile izinyanga ezingaphezu kwezintathu (lapho ejwayele ukuhlala njalo) noma ngaphezulu kwezinyanga eziyisithupha (uma bekungavamile). Kunezimbangela eziningana zezimbangela ze-amenorrhea yesibili kubandakanya:
- Ukukhulelwa
- Isifo se-thyroid
- I-Polycystic ovarian syndrome
- Izinga eliphezulu leprolactin
- I-amenorrhea ye-hypothalamic: isimo esingase siphumelele ngenxa yokucindezeleka, ukulahlekelwa ngokweqile, noma ukuvivinya umzimba
Ukuze uthole imbangela yamaminerrhea wesibini wesifazane, udokotela uzolawula inombolo yezivivinyo ezifana nokuhlolwa kokukhulelwa, ama-hormone egazi, nokuhlolwa kwenselelo ye-progesterone (ebizwa nangokuthi uhlolo lwe-progesterone ukuhoxiswa).
Esivivinyweni se-progesterone inselele, owesifazane angabekwa ama-milligram noma ama-milligram angu-10 ka-Provera izinsuku ezinhlanu kuya kwezingu-10 ukuze abone ukuthi uthola ukuphuma kwegazi.
Uma owesifazane engaboni ukuphuma kwegazi emasontweni amabili ngokuthatha iPravera, khona-ke kungenzeka ukuthi unamazinga e-estrogen ephansi emzimbeni wakhe noma une-disorder tract disorder, njengo-Asherman's syndrome.
Uma owesifazane ezwa ukuphuma kwegazi (okuvamise kwenzeka ezinsukwini ezintathu kuya kweziyisikhombisa zokumisa u-Provera) ke une-estrogen eyanele emzimbeni wakhe, ngakho-ke i-amenorrhea yakhe ingeyona i-ovulating (ebizwa ngokuthi i-anovulation).
Kulokhu, udokotela uzobe enza izivivinyo ezingaphezulu ukuze athole isizathu sokugcoba kwakhe.
I-provera kanye nokukhipha ukubeletha okungavamile
Uma owesifazane ene-anovulation engapheli, angase ahlakulele ukuphuma kwe-uterine okungavamile, okungenzeka ukuthi ukuphuma esikhathini esingavamile noma ngokweqile ukuphuma esikhathini. Inkinga nge-anovulation engapheli yikho ukuthi ingaholela ekukhuleni komzimba wesibindi, okuthiwa i- endometrial hyperplasia , engaba ngumdlavuza wesibeletho.
I-Polycystic i-ovary syndrome (i-PCOS) yisibonelo esivela esimweni esivame ukudala ukuhamba esikhathini esingavamile kusuka ekugcokeni okungapheli. I-Polycystic syndrome ye-ovary syndrome yinto ejwayelekile kunazo zonke ze-endocrine disorder kulabo besifazane abaneminyaka yobudala yokubeletha. Izici ezimbili ezicacile ze-PCOS yizikhathi ezingavamile kanye namazinga aphezulu we-androgens (njenge-testosterone), okufaka isandla ekwakhiweni kwe-acne ne-hirsutism. Izinkinga ze-metabolic ezifana nokukhuluphala ngokweqile nokuphikiswa kwe-insulin nazo zivame ku-PCOS.
Ngokuvamile, inhlanganisela yokuvimbela isrogen-progestin yokuhlanganisa (isibonelo, "Iphilisi") inconywa ngabesifazane abane-PCOS, ukulawula imijikelezo yokuya esikhathini, ukuvikela uketshezi lwe-uterine ekukhuleni, futhi nokuphatha imiphumela yokuba namazinga aphakeme a-androgen (for isibonelo, induna).
Kulabo besifazane abangakwazi ukuthatha noma bakhetha ukungathathi isisu se-estrogen-progestin ehlangene, i-Provera iyindlela yokukhetha.
I-Provera isebenza ngokuvimbela ukugqama kwezicubu ezinhlakeni zobunini.
I-Provera ne-Hormone Alternative Therapy
I-Provera ingasetshenziswa futhi ngokuhlanganiswa ne-estrogen kubesifazane be-postmenopausal abanesibeletho. Inhlanganisela ye-estrogen ne-progesterone ibizwa ngokuthi i-hormone therapy esikhundleni sokuthi uphinde uthole inhloso yayo ukuphatha izimpawu ezihlobene nokunqamuka kokuya esikhathini sokufana nokukhanya okushisayo.
Inhloso ye-progesterone ngaphezu kwe-estrogen ukuvimbela ukuqina kwesibeletho. Yingakho i-progesterone inikwa kuphela abesifazane abasenayo isibeletho. Noma i-Provera noma i-progesterone yemvelo (ngokuvamile) inqunywe.
I-hormone-substitution therapy kufanele isetshenziswe kumthamo ophansi kunawo wonke futhi isikhathi esifushane kunokwenzeka, ucabange ingozi yowesifazane futhi izinzuzo zokuthatha ukwelapha okushintshe ama-hormone zilinganisiwe futhi zixoxwa kahle.
Ngaphezu kwalokho, kubalulekile ukukhumbula ukuthi noma yikuphi ukuphaphaza kwamagciwane kumfazi we-postmenopausal onesibeletho kufanele kuhlolwe ukulawula umdlavuza.
Yini Engayilindela Ngokuthatha Provera
Njengoba i-Provera i-hormone, ingabangela imiphumela emibi. Izinto ezivame kakhulu ziyinhloko, isicanucanu, isifuba sebele, nokushintsha kwemizwelo. Le miphumela emibi kufanele ifinyelele ezinsukwini ezimbalwa ngemuva kokuthatha iPravera.
Ezinye imiphumela emibi ingafaka:
- Shintsha ukuphuma kwesikhashana noma ukugeleza
- I-acne
- Ukwandisa isisindo
- Izinkinga zokukhathala noma zokulala
Kubalulekile ukuqaphela ukuthi i-Provera iphikisana nokukhulelwa, ngakho-ke qiniseka ukuthi utshele udokotela wakho uma ucabanga ukuthi ungakhulelwa. Ngezinye izikhathi udokotela wakho uzodinga ukuthi uthathe isilingo sokukhulelwa kwegazi noma umchamo ngaphambi kokuthatha le mithi.
Ngaphezu kwalokho, i-Provera ngokwayo akuyona indlela enokwethenjelwa yokwelapha, nakuba i-hormone. Uma uthatha u-Provera, qiniseka ukuthi usebenzisa isisu sokuvimbela (isibonelo, ikhondomu) ukuvimbela ukukhulelwa.
Buyekeza zonke izinkinga zakho zezokwelapha kanye nemithi nodokotela wakho ngaphambi kokuthatha iPravera. Ngaphandle kokukhulelwa, kunezinye izinkolelo zokuthatha iPravera ngaphezu kwemiphumela emibi, ikakhulu uma ihlanganiswa ne-estrogen.
Izwi elivela
Inhloso evamile kakhulu yokumisela iPravera ukusiza udokotela ukuxilonga noma ukuphatha izinkinga zokujikeleza kokuya esikhathini njengokungavamile kokuphuma noma ukungabi khona kwezikhathi. Ibuye isetshenziselwe ukuvimbela ukwanda kwemigodi ye-uterine kubesifazane be-postmenopausal abasebenzisa i-estrogen. Kungaba nzima ukuqonda ukuthi kungani uthatha i-hormone ethile, njengo-Provera. Qiniseka ukuletha noma yimiphi imibuzo noma ukukhathazeka nodokotela wakho.
> Imithombo:
> Kaunitz AM. Ukulawulwa Kwegazi Lokungavamile Okukhipha Uterine. Ku: UpToDate, Barbieri RL (Ed), UpToDate, Waltham, M
> Ndefo UA, Eaton A, MG Green. I-Polycystic Ovary Syndrome: Ukubuyekezwa Kwezinketho Zokwelapha Ngokugxila Emikhondweni Yezokwelapha. Pharmacy and Therapeutics. 2013 Jun; 38 (6): 336-338, 348, 355.
> Provera (i-Medroxyprogesterone Acetate). I-Pfizer. https://www.pfizer.com/products/product-detail/provera.
> Sweet MG, Madsen KP. Ukuhlola nokuphathwa kwe-Abnormal bleeding in the Premenopausal Women. I-American Family Physician. 2012 Jan 1; 85 (1): 35-43.