Izakhi ozitholayo kubazali bakho zithinta ukubonakala komzimba wakho, njengombala wamehlo kanye nama-freckles, kanye nezinye izici, ezifana nohlobo lwegazi nokubona okubonakalayo. Futhi akusikho konke. Izakhi zofuzo ezizuzwayo nazo zingasiza ukunquma amakhono amakhono omzimba wakho - njengokuvimbela umdlavuza wesifo sofuba kusuka ekuphindaphindiwe.
Indlela I-Cancer Prostate Ikhula ngayo
I-Androgens (ama-hormone wesilisa abesilisa) enza umdlavuza wesi-prostate ukhule.
Ngakho-ke, i- androgen therapy therapy (ADT) yindlela eyodwa yokuphatha umdlavuza wesifo sofuba , ikakhulu uma usuqhubekela phambili noma usakazekile. I-ADT ingabandakanya ukuphuza imithi evimba i-androgen ekukhiqizeni (kumathambo) noma ivimbele umphumela we-androgen kuwo wonke umzimba wakho. I-ADT nayo ingabandakanya ukukhishwa kwamagciwane womabili. Kuvame ukusetshenziselwa ukwengeza kwezinye izindlela zokwelapha umdlavuza we-prostate, njengokwelashwa kwe-radiation noma ukususwa kwe-prostate.
I-ADT, empeleni, isusa uphethiloli futhi igweme amangqamuzana omdlavuza wesifo sofuba kusuka ekukhuleni - noma okungenani ibambe kancane.
Kodwa, ezimweni eziningi, i-ADT isebenza kuphela isikhathi eside. Amaseli omdlavuza we-prostate ngokuvamile abe "ukumelana nokuxoshwa" ekugcineni. Baqala ukwenza i-androgen yabo, ngaleyo ndlela baziphucula ngokwabo.
Amadoda athola i-ADT ye-prostate umdlavuza anezivivinyo ezivamile ze- prostate-specific antigen (PSA) . Amazinga aphakama e-PSA angase akhombise ukuthi umdlavuza we-prostate uye waba ukumelana ne-castration futhi usuqala ukukhula futhi.
I-Genesini Qinisekisa Ikhono Lakho Lokulwa Nomdlavuza We-Prostate
Amanye amadoda angasebenzisa i-ADT ukugcina umdlavuza wesi-prostate isikhathi eside kunabanye.
Ucwaningo olwenziwa ngo-2016 eCleveland Clinic neMayo Clinic lathola ukuthi amadoda anesimo esithile segesi ekhethekile angase abe nomdlavuza omelana nesifo se-prostate ngokushesha. Kula madoda, i-ADT ayisebenzi isikhathi eside.
Umdlavuza wabo uzobuyela ngokushesha.
Iziguli ezingama-443 zomdlavuza wesi-prostate esifundweni, bonke babe nezifo eziphambili futhi baphathwa nge-ADT. Amanye amadoda ayenomzimba "ojwayelekile" we- HSD3B1 - amakhophi amabili, eyodwa kusuka kumzali ngamunye. Ezinye zazihlukile , i- HSD3B1 (1245C), kodwa kuphela kumzali oyedwa. Kanti abanye babenegene elihlukile kubo bobabili abazali.
Amakhophi amaningi we-gene ehlukile, i-ADT encane esebenza.
Labo abanezakhi zofuzo "ezijwayelekile" esigabeni saseCleveland Clinic seziguli bayeka umdlavuza we-prostate ukuphindaphinda iminyaka engama-6.6. Abanye abazange baphumelele. Labo abanesisindo esivela kumzali oyedwa bavame ukuphindaphinda iminyaka engama-4.1. Labo abanesisindo esivela kubo bobabili abazali bavame ukuphindaphinda iminyaka engama-2.5 nje kuphela.
Ingabe Unayo I-Gene Ehlukile?
Ngokomsebenzi we-Genomes we-1000, cishe isigamu samadoda nabesifazane base-United States bane- HSD3B1 (1245C) geni-kusuka kubani noma bobabili abazali.
Okwamanje, akukhona ukuhlolwa okulula ukukubona (nakuba kungabonakala ephaneli ephelele yezakhi zofuzo). Ucwaningo olwengeziwe luyadingeka ngaphambi kokuhlolwa kwegazi kwe- HSD3B1 (1245C) kwenziwa kabanzi.
Kungani kungenjalo manje? Ngenxa yokuthi abukho ubufakazi obanele bokushintsha ukwelashwa kwamadoda anegene ehlukile kuzokwenza ngcono imiphumela.
Senza ucwaningo olwengeziwe manje ukubona ukuthi ezinye izindlela zokwelapha ze-hormone zizosebenza kangcono kune-ADT kula madoda. Uma benza, sizoba nobufakazi bokuthi ukuhlolwa kwegazi okulula kufanele kuhlinzekwe kwesikrini ku- HSD3B1 (1245C).
Ukwelashwa Okungenziwa Ngokwezifiso Kungaphumelela Kakhulu
Namuhla siphatha zonke iziguli ezine-cancer ephindaphindiwe yomdlavuza ngokwezinga elilodwa lokunakekelwa. Kodwa ucwaningo lungasishukumisela ukuba sibheke ezenzweni zokwelashwa esekelwe izici zofuzo zesiguli.
Esikhathini esizayo esingekho kakhulu, sithemba ukusebenzisa izivivinyo zofuzo ukuze sithole ukuthi iziphi iziguli ezidinga ukuthi yiluphi ukwelapha, esikhundleni sokuphatha wonke umuntu ofanayo.
Isibonelo, iziguli ezingenayo igesi le- HSD3B1 (1245C) zingahamba kahle nge-ADT. Labo abanalo bangase badinge ukwelashwa okunamandla.
UDkt. Sharifi ungumhlengikazi wezokwelapha eCleveland Clinic sikaTaussig Cancer Institute futhi uphethe uSihlalo weKendrick Family Endowed Research for Prostate Cancer Research eCleveland Clinic.
> Imithombo:
> Hearn JW, Abuali G, Reichard CA, et al. I-HSD3B1 nokuphikisa ukwelashwa kwe-androgen-ukunqandwa komdlavuza wesi-prostate: ukutadisha okuphindaphindiwe, okufundwa yi-multicohort. I-Lancet Oncol. 2016; 17 (10): 1435-1444.