I-BRCA1 ne-BRCA2 ukuguquguquka kwandisa ingozi yomdlavuza webele ne-ovarian.
Uyazi ukuthi ukuhlolwa kwe- BRCA kunomsebenzi owenziwe ngomdlavuza webele ne-ovarian. Kodwa-ke, yiyo yonke iningi labantu abakwaziyo nge- BRCA1 ne- BRCA2 ukuguqulwa komzimba, futhi uma kwakungeyona inguquko ye-Angelina Jolie yokuhlola ukuguqulwa kwe-BRCA1 futhi ngemuva kokuthola i-prophylactic mastectomy (ukukhetha ukususwa kwebele) kanye ne-prophylactic salpingo-oophorectomy kamuva (ukususwa kokukhetha ama-tublopian tubes nama-ovari), iningi lamaMelika ngeke likwazi ngisho nalokhu okuningi.
Umsangqangi angasho ukuthi iqiniso lokuthi abantu abaningi abazi kangako ukuhlolwa kwe- BRCA kuyinto enhle. Ngempela, kusekhona okuningi esingasazi mayelana nokuguqulwa kwe- BRCA , futhi abaningi bacabanga ukuthi akufanele sithembele ekuvivinyeni okuthola ukuguqulwa okwamanje okwamanje okuncane okwenza izinqumo ezithintekayo zokunakekelwa kwezempilo kubandakanya i-prophylactic mastectomy ne-salpingo-oophorectomy ukuvimbela umdlavuza wesikhathi esizayo.
Noma kunjalo, naphezu kwalokho abagxeki bathi, iningi labalangali bakholelwa emandleni okuhlolwa kwe- BRCA ukuze kutholakale ukufakwa kwesifo somdlavuza webele ne-ovarian - ikakhulukazi ngoba ngokungafani nomdlavuza webele, akukho ukuhlolwa okuhle komdlavuza we-ovarian. Ngenxa yokuthi ukuhlolwa kwe- BRCA kuyathandwa futhi kungabonisa inzuzo yezempilo yokuvikela emncane kwabesifazane, kuwumqondo omuhle ukuthi uqonde kangcono le modal yokuhlola.
Izinguquko ze-BRCA
I-BRCA1 ne- BRCA2 ziyi-gummy-suppressor geni. Uma owesifazane ezuza i-mutations kunoma iyiphi yalezi zakhi zofuzo ezithinta izinhlangothi zombili, ingozi yakhe yebele ne-ovarian cancerrockets.
Ngokuqondile, nge- BRCA1 ne- BRCA2 ukuguqulwa komzimba, ingozi yokugcina umdlavuza webele isengaphezu kwamaphesenti angama-80; kanti, ingozi yokuba nomdlavuza we-ovarian ingamaphesenti angaba ngu-40 nge- BRCA1 ukuguqulwa kwamaphesenti kanye namaphesenti angu-20 nge- BRCA2 .
Umdlavuza webele nowesi-ovari ohlangene nezinguquko ze- BRCA zivame ukuhlukumezeka futhi zivame ukushayisana ngesikhathi esincane (cabanga abesifazane besema-20s).
Ukuze silwe nalokhu kusongela okungaqondakali, abantu abahlakaniphile kakhulu beza negazi lofuzo noma ukuhlolwa kwe-sali okungenziwa enqenqemeni noma esimweni somtholampilo.
Kufanele Uhlolwe i- BRCA ?
Okokuqala, amaphesenti angu-5 kuphela ekhansela lamabele alungele futhi adluliselwe ngamama wakho noma ama-pops. Ngakho-ke, ukuhlolwa kwe- BRCA akuwona wonke umuntu, futhi akuyona indlela yokuhlola jikelele.
Lapho ucabangela ukuthi ungumuntu omele ukuhlolwa kwe- BRCA , udokotela wakho uzocabangela lezi zinto ezilandelayo:
- I-Ashkenazi ifa lamaJuda
- Isiqu sokuqala sihlobene nomdlavuza webele ngaphambi kokungu-50
- zihlobene nomdlavuza wesifuba esisodwa
- umlando womuntu siqu noma womndeni wesifo somdlavuza we-ovarian
- umlando womndeni we-cancer ye-peritoneal
- kokubili umdlavuza webele noma ovariya ukhona ngesihlobo
- izihlobo ezimbili noma ngaphezulu ngomdlavuza webele
- ilungu lomndeni wesilisa ngomdlavuza webele
Uma unomlando womndeni wokuguqulwa kwe- BRCA , uhlolwe kuphela uhlobo lokuguqulwa kwe-BRCA olugijima emndenini wakho: BRCA1 noma i- BRCA2 .
Yini Okumele Uyenze Uma Uzovivinya Okuhle kwe-BRCA1 noma ye-BRCA2?
Kunokuphikisana okuningi mayelana nendlela yokuqhubeka nomphumela omuhle we- BRCA1 noma we- BRCA2 . Nazi ezinye zezindlela zokulawulwa kwezinhlekelele:
- ukuhlolwa okuvamile okubandakanya izidakamizwa, i-MRI, i-ultrasound kanye nesilinganiso somdlavuza-antigen 125;
- i-chemoprevention ne-chemotherapy agents i-tamoxifen noma i-raloxifene;
- umthamo wokunciphisa ingozi noma i-salpingo-oophorectomy.
Sicela wazi ukuthi ukususa amabele. ama-ovari kanye nama-tublopian tubes kungenye yezindlela zokuphatha ingozi, futhi ukhetho lwalolu khetho luxhomeke esimweni sakho somtholampilo. Ngaphezu kwalokho, nakuba i-mastectomy isusa kakhulu izicubu zesifuba, ayisususi zonke izicubu zesifuba, kanti kusekhona ithuba elincane lokuthi ungase ube nomdlavuza. Okokugcina, ukuhlinzwa okunjalo kwenziwa emva kwezinyanga zokwelulekwa kwezakhi zofuzo kanye nokuhlolwa kokuhlinzwa.
Uma unomuzwa wokuthi ungase ube engozini yomdlavuza wesibeletho noma i-ovarian, kungumqondo omuhle ukuxoxa ngalokhu okusola ngudokotela wakho oyinhloko noma udokotela wezifo-mzimba.
Okuphawulayo, iCDC ikhombisa ukuthi abesifazane abathintekayo basebenzisa i-Know: BRCA ithuluzi lokuhlola ingozi yomuntu siqu. Ngemuva kokuthola umlando womuntu siqu nomndeni wakho, udokotela wakho anganquma ukuthi ungumqashi omuhle we- BRCA1 noma we- BRCA2 .
Imithombo ekhethiwe
Hunt KK, Robertson JR, Bland KI. Isibeletho. Ku: Brunicardi F, Andersen DK, B Billiar, Dunn DL, Hunter JG, Matthews JB, Pollock RE. ama-eds. Izimiso Zokuhlinza Schwartz, 10e . ENew York, NY: McGraw-Hill; 2014. Kufinyelelwe ngoJuni 25, 2015.
I-LeBlond RF, i-Brown DD, i-Suneja M, i-Szot JF. I-genitalia yamaGciwane kanye nohlelo lokuzala. Ku: LeBlond RF, Brown DD, Suneja M, Szot JF. ama-eds. Ukuhlolwa kweDiagnostic Diagnostic, 10e . ENew York, NY: McGraw-Hill; 2015 .. Ifinyelele ngoJuni 25, 2015.