Ijusi le-Grapefruit liyaziwa ukuxhumana nemithi eminingi , okwandisa umphumela wayo emazingeni ahlukahlukene anobuthi. Ngakho-ke, uma kuziwa ku-Plavix (clopidogrel), imithi egazini yegazi esetshenziselwa ukunciphisa ukusabalala kwesifo sohlangothi nesifo somzimba, ingabe iphephile ukudla ijusi yethamo? Impendulo emfushane ingu "cha."
I-Grapefruit Juice ihlangana kanjani ne-Plavix?
Ucwaningo olwenziwa ngo-2014 oluthola ijusi lamagilebhisi luvimbela kokubili i-CYP3A4 enzyme, i-clopidogrel iyinhlangano engaphansi komhlaba, kanye ne-CYPC19 enzyme, ehlanganisa umzimba.
Ngakho-ke umusi we-grapefruit ungaphazamisa ukuguqulwa kwe-clopidogrel kwifomu layo elisebenzayo, ngaleyo ndlela ukunciphisa umuthi we-antiplatelet wezidakamizwa ezidingekayo ukuze uvimbele ukushaywa noma isifo senhliziyo.
Emzimbeni, i-clopidogrel isetshenziswe ngokusetshenziswa kwe-CYP2C19 enzyme. Kodwa-ke, abantu abathile bangama-metabolizers abampofu we-CYP2C19 enzyme. Laba bantu bayamelana ne-clopidogrel. Nakuba kukhona ukuhlolwa kwegazi ukukhomba iziguli ezingamelana ne-clopidogrel ngaphambi kwesikhungo sokwelashwa ngemithi, lolu hlelo alusetshenziswanga kabanzi. Okuphawulayo, abantu abasebenzisa imishini ye-clopidogrel empofu, futhi banomngcipheko owengeziwe wokushona kwezenzakalo zenhliziyo noma ukucindezeleka okuqinile.
Ngokusho kombiko we-FDA, ezinye izidakamizwa zenhliziyo ezithinta i-grapefruit juice zihlanganisa:
- statins (njengeZocor noLipitor)
- Imithi yokucindezelwa kwegazi njenge-nifedipine
- imithi yokulwa ne-anti-arrhythmia njenge-amiodarone
Ngaphezu kwemithi ye-heart, ijusi le-grapefruit liphinde lithinte izidakamizwa ezilandelayo:
- imithi esetshenziselwa ukufakelwa komzimba njenge-cyclosporine
- imishanguzo yokulwa nokukhathazeka njengebhasipirone
- antihistamines njenge-Allegra
Ijusi yamagilebhisi ingaba yingxenye enempilo yokudla. Uma unesifo senhliziyo, sicela uxoxe ukuthi ingabe umqondo omuhle ukuphuza ijusi lamagilebhisi noma udokotela wakho noma omunye umhlinzeki wezempilo.
Qinisekisa ukwazisa umhlinzeki wakho wezempilo wezo zonke izidakamizwa ozithathayo kanye nemilinganiselo yale mithi.
Izwi elivela
Kuhlale kungumqondo omuhle ukufunda ngokucophelela ukushicilelwa okushicilelwe okuza ne-clopidogrel. Kufanele kube nesigaba mayelana nokuxhumana phakathi kwe-clopidogrel neminye imithi. Uma ungatholi i-iphakheji efakiwe, cela umkhomikhali wakho ikhophi.
Uma usebenzisa noma yimiphi imithi engaphezu kuka-i-counter (i-OTC) noma izithako zokudla, kufanele ukhulume nomklami wakho kanye nodokotela mayelana nokuxhumana okungenzeka. Kufanele uqaphele ikakhulukazi ngokusebenzisa imithi yokuvuvukala njenge-ibuprofen ne-OTC enezithako eziqukethe i-ginkgo. Umphumela wecala wale mikhiqizo uphepha.
> Imithombo:
> Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, i-Niemi M. I-jupe yamagilebhisi evimbela ukusebenza kwe-clopidogrel. I-Clin Pharmacol Ther . 2014 kuya: 10.1038 / clpt.2013.192
> IKrasowski MD. Pharmacogenomics. Ku: South-Paul JE, Matheny SC, Lewis EL. ama-eds. Ukuqapheliswa kwe-CURRENT & Ukwelashwa: Imithi Yomndeni, 4e . ENew York, NY: McGraw-Hill; 2015.
> Trevor AJ, Katzung BG, iKruidering-Hall M. Pharmacogenomics. Ku: Trevor AJ, Katzung BG, Kruidering-Hall M. eds. I-Katzung & Trevor's Pharmacology: Ukuhlolwa Nokuhlolwa KweBhodi, 11e . ENew York, NY: McGraw-Hill; 2015.