Ijusi yamagilebhisi evimbela ukuwohloka kwemithi ethile.
Yebo, i-grapefruit juice egcwele-igcwele amavithamini nezakhi. Kwabaningi, ingilazi yejusi yamagilebhisi iyindlela enhle yokuqala usuku. Kodwa-ke, uma unemithi ethile, njengemithi ethile yempilo ebizwa ngokuthi i-statins, kufanele ugweme ukuphuza ijusi lamagilebhisi ngenkathi uthatha le mithi. Ijusi lamagilebhisi lingavimbela amandla omzimba wakho wokuphulukisa le mithi, futhi yona ingabangela imiphumela emibi.
IJupefruit Juice kanye nezitatimende ezithile azihlanganisi
Ijusi lamagilebhisi nemifino ethile (esetshenziselwa ukwelapha i-cholesterol ephakeme) efana ne- Lipitor (atorvastatin), i-Mevacor (lovastatin), ne-Zocor (simvastatin) ayihlanganisi. Ijusi yamagilebhisi ivimbela uhlelo lwezinyomi ezisiza ukudiliza inqwaba yemithi, kuhlanganise neLimpitor, Mevacor, neZocor .
Uma uphuza isiphuzo se-grapefruit ngenkathi uthatha noma iyiphi yale mithi, isithako esiningi esisebenzayo singasebenzisa ukuhamba kwegazi lakho. Lokhu kungaholela emiphumeleni emibi, njengengozi eyingozi yemisipha noma ukulimala kwesibindi. Ngokuqondile, ijusi lamagilebhisi luvimbela uhlelo lwe-enzyme ye-hepatic (isibindi) i-P450, ephula izidakamizwa.
Ngokuhambisa nge-enzyme yesibindi, isithako esisebenzayo sithinta umzimba wakho. Ngamanye amazwi, imiphumela yezidakamizwa ze-statin yanda kubantu abaphuza ijusi le-orange. Imiphumela emibi ye-statins ihlanganisa ukulimala kwesisipha nesibindi.
Ama-enzyme e-Cytochrome P450 agcinwa ku-reticulum endoplasmic yamaseli ayitholakali kuphela esibindi kodwa futhi ezintsheni, emathunjini emathunjini namaphaphu.
Lezi zinkimbinkimbi ze-P450 ziphuza izidakamizwa phansi nge-oxyidizing. Ngaphandle kwejusi lamagilebhisi, ikakhulukazi ama-furanocoumarins enjusi yamagilebhisi, ezinye izinto zivimbela ama-enzyme e-cytochrome P450 kuhlanganise ne-cimetidine (i-histamine blocker esetshenziselwa ukuphatha i-GERD), i-erythromycin (i-antibiotic) ne-isoniazid (imithi esetshenziselwa ukwelapha isifo sofuba).
Sicela ugcine engqondweni ukuthi kunezidakamizwa eziningana ezithuthukisa nge-cytochrome P450, futhi uma unemibuzo mayelana nokuxhumana okungenzeka, sicela uxoxe nabo nodokotela wakho. Udokotela wakho kufanele futhi ahlole ukuthi imithi oyithathayo ingaba nokuthintana kabi komunye nomunye noma ngokudla kwakho.
Isikhathi osithatha ngayo enye yale mithi kanye nesikhathi odla ngayo i-grapefruit noma uphuze ijusi lamagilebhisi asinciphisi umngcipheko wakho wemiphumela emibi ehlobene nezidakamizwa - ukuxhumana kungenzeka kuze kube yizinsuku ezintathu emva kokudla imivini yamagilebhisi. Lokhu kusho ukuthi awukwazi ukuphuza ijusi lamagilebhisi ekuseni bese uthatha imithi yakho kamuva ngosuku.
Izinketho zemithi
Unezinketho eziningana:
- Ungakwazi ukukhipha i-grapefruit ekudleni kwakho futhi ufake ezinye izithelo nezithelo zezithelo, noma
- Uma ufuna ukuqhubeka nokudla imikhiqizo yamagilebhisi, khuluma nodokotela wakho mayelana nokusebenzisa imithi ehlukile.
Izitembu eziningana ezitholakalayo azisebenzisani nejusi lamagilebhisi futhi ziphephile ukusebenzisa. Lokhu kufaka:
- I-Crestor (i-rosuvastatin)
- I-Lescol (i-fluvastatin)
- I-Pravachol (i-pravastatin)
Ulwazi olungaphezulu
Uma unemibuzo mayelana nokusebenzisana kwezidakamizwa nejusi lamagilebhisi, sicela uxoxe ngalokhu okukhathazayo nodokotela wakho.
Sicela ukhumbule ukuthi udokotela wakho ungumthombo omuhle wolwazi futhi ukhona ukukusiza ukukuqondisa ngemithi yokwelashwa futhi usebenze ukuqinisekisa impilo yakho enhle.
Imithombo ekhethiwe
Isihloko esithi "Ukusebenzisana kwezidakamizwa ngenxa ye-cytochrome P450" yiCC Ogu noJL Maxa eshicilelwe eBaylor University Medical Center Proceedings ngo-2000.
Trevor AJ, Katzung BG, i-Kruidering-Hall M. Antifungal Agents. Ku: Trevor AJ, Katzung BG, Kruidering-Hall M. eds. I-Katzung & Trevor's Pharmacology: Ukuhlolwa Nokuhlolwa KweBhodi, 11e . ENew York, NY: McGraw-Hill; 2015. Kufinyelelwe ngoFebhuwari 29, 2016.